Peyer's patch organogenesis as a programmed inflammation

A hypothetical model

Shin Ichi Nishikawa, Satomi Nishikawa, Kenya Honda, Hiroyuki Hashi, Hisahiro Yoshida

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Gene-knock-out studies implicate roles of lymphotoxin (LT) αβ and LTβR in the initial phase of Peyer's patch (PP) organogenesis. We recently identified the requirement of IL-7Rα/γc/Jak3 signal in LTαβ production of IL-7Rα+ cells. These observations lead us to a hypothetical model for PP organogenesis with three cellular components. The first is the producer of the ligand for IL-7Rα, which then stimulate the IL-7Rα+ cells to produce LTαβ, activating the LTβR+ cells to form an organizing center for PP organogenesis. This model is similar to that of inflammation, suggesting that PP organogenesis is a programmed version of inflammation.

Original languageEnglish
Pages (from-to)213-220
Number of pages8
JournalCytokine and Growth Factor Reviews
Volume9
Issue number3-4
DOIs
Publication statusPublished - 1998 Dec 1
Externally publishedYes

Fingerprint

Lymphotoxin-alpha
Peyer's Patches
Organogenesis
Inflammation
Gene Knockout Techniques
Genes
Ligands

Keywords

  • GALT (gut associated lymphoid tissue)
  • IL-7 receptor
  • Inflammation
  • Lymphotoxin
  • Peripheral lymphoid tissue
  • Peyer's patch

ASJC Scopus subject areas

  • Immunology
  • Endocrinology, Diabetes and Metabolism
  • Immunology and Allergy
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Peyer's patch organogenesis as a programmed inflammation : A hypothetical model. / Nishikawa, Shin Ichi; Nishikawa, Satomi; Honda, Kenya; Hashi, Hiroyuki; Yoshida, Hisahiro.

In: Cytokine and Growth Factor Reviews, Vol. 9, No. 3-4, 01.12.1998, p. 213-220.

Research output: Contribution to journalArticle

Nishikawa, Shin Ichi ; Nishikawa, Satomi ; Honda, Kenya ; Hashi, Hiroyuki ; Yoshida, Hisahiro. / Peyer's patch organogenesis as a programmed inflammation : A hypothetical model. In: Cytokine and Growth Factor Reviews. 1998 ; Vol. 9, No. 3-4. pp. 213-220.
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