Peyer's patch organogenesis as a programmed inflammation: A hypothetical model

Shin Ichi Nishikawa; Satomi Nishikawa; Kenya Honda; Hiroyuki Hashi; Hisahiro Yoshida

doi:10.1016/S1359-6101(98)00014-8

Peyer's patch organogenesis as a programmed inflammation: A hypothetical model

Shin Ichi Nishikawa, Satomi Nishikawa, Kenya Honda, Hiroyuki Hashi, Hisahiro Yoshida

Research output: Contribution to journal › Short survey › peer-review

3 Citations (Scopus)

Abstract

Gene-knock-out studies implicate roles of lymphotoxin (LT) αβ and LTβR in the initial phase of Peyer's patch (PP) organogenesis. We recently identified the requirement of IL-7Rα/γc/Jak3 signal in LTαβ production of IL-7Rα⁺ cells. These observations lead us to a hypothetical model for PP organogenesis with three cellular components. The first is the producer of the ligand for IL-7Rα, which then stimulate the IL-7Rα⁺ cells to produce LTαβ, activating the LTβR⁺ cells to form an organizing center for PP organogenesis. This model is similar to that of inflammation, suggesting that PP organogenesis is a programmed version of inflammation.

Original language	English
Pages (from-to)	213-220
Number of pages	8
Journal	Cytokine and Growth Factor Reviews
Volume	9
Issue number	3-4
DOIs	https://doi.org/10.1016/S1359-6101(98)00014-8
Publication status	Published - 1998 Dec 1
Externally published	Yes

Keywords

GALT (gut associated lymphoid tissue)
IL-7 receptor
Inflammation
Lymphotoxin
Peripheral lymphoid tissue
Peyer's patch

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Immunology and Allergy
Immunology
Biochemistry, Genetics and Molecular Biology(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/S1359-6101(98)00014-8

Cite this

@article{055ba985e99d4a79955471d3486a7b8d,

title = "Peyer's patch organogenesis as a programmed inflammation: A hypothetical model",

abstract = "Gene-knock-out studies implicate roles of lymphotoxin (LT) αβ and LTβR in the initial phase of Peyer's patch (PP) organogenesis. We recently identified the requirement of IL-7Rα/γc/Jak3 signal in LTαβ production of IL-7Rα+ cells. These observations lead us to a hypothetical model for PP organogenesis with three cellular components. The first is the producer of the ligand for IL-7Rα, which then stimulate the IL-7Rα+ cells to produce LTαβ, activating the LTβR+ cells to form an organizing center for PP organogenesis. This model is similar to that of inflammation, suggesting that PP organogenesis is a programmed version of inflammation.",

keywords = "GALT (gut associated lymphoid tissue), IL-7 receptor, Inflammation, Lymphotoxin, Peripheral lymphoid tissue, Peyer's patch",

author = "Nishikawa, {Shin Ichi} and Satomi Nishikawa and Kenya Honda and Hiroyuki Hashi and Hisahiro Yoshida",

note = "Funding Information: Acknowledgements:This study is supported by grants from the Ministry of Education, Science, Sports and Culture of Japan (Nos 07CE2005, 06277102 and 06NP1101).",

year = "1998",

month = dec,

day = "1",

doi = "10.1016/S1359-6101(98)00014-8",

language = "English",

volume = "9",

pages = "213--220",

journal = "Cytokine and Growth Factor Reviews",

issn = "1359-6101",

publisher = "Elsevier BV",

number = "3-4",

}

TY - JOUR

T1 - Peyer's patch organogenesis as a programmed inflammation

T2 - A hypothetical model

AU - Nishikawa, Shin Ichi

AU - Nishikawa, Satomi

AU - Honda, Kenya

AU - Hashi, Hiroyuki

AU - Yoshida, Hisahiro

N1 - Funding Information: Acknowledgements:This study is supported by grants from the Ministry of Education, Science, Sports and Culture of Japan (Nos 07CE2005, 06277102 and 06NP1101).

PY - 1998/12/1

Y1 - 1998/12/1

N2 - Gene-knock-out studies implicate roles of lymphotoxin (LT) αβ and LTβR in the initial phase of Peyer's patch (PP) organogenesis. We recently identified the requirement of IL-7Rα/γc/Jak3 signal in LTαβ production of IL-7Rα+ cells. These observations lead us to a hypothetical model for PP organogenesis with three cellular components. The first is the producer of the ligand for IL-7Rα, which then stimulate the IL-7Rα+ cells to produce LTαβ, activating the LTβR+ cells to form an organizing center for PP organogenesis. This model is similar to that of inflammation, suggesting that PP organogenesis is a programmed version of inflammation.

AB - Gene-knock-out studies implicate roles of lymphotoxin (LT) αβ and LTβR in the initial phase of Peyer's patch (PP) organogenesis. We recently identified the requirement of IL-7Rα/γc/Jak3 signal in LTαβ production of IL-7Rα+ cells. These observations lead us to a hypothetical model for PP organogenesis with three cellular components. The first is the producer of the ligand for IL-7Rα, which then stimulate the IL-7Rα+ cells to produce LTαβ, activating the LTβR+ cells to form an organizing center for PP organogenesis. This model is similar to that of inflammation, suggesting that PP organogenesis is a programmed version of inflammation.

KW - GALT (gut associated lymphoid tissue)

KW - IL-7 receptor

KW - Inflammation

KW - Lymphotoxin

KW - Peripheral lymphoid tissue

KW - Peyer's patch

UR - http://www.scopus.com/inward/record.url?scp=0344527964&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0344527964&partnerID=8YFLogxK

U2 - 10.1016/S1359-6101(98)00014-8

DO - 10.1016/S1359-6101(98)00014-8

M3 - Short survey

C2 - 9918121

AN - SCOPUS:0344527964

SN - 1359-6101

VL - 9

SP - 213

EP - 220

JO - Cytokine and Growth Factor Reviews

JF - Cytokine and Growth Factor Reviews

IS - 3-4

ER -

Peyer's patch organogenesis as a programmed inflammation: A hypothetical model

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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