pH-independent fluorescent chemosensor for highly selective lithium ion sensing

Daniel Citterio, Junichiro Takeda, Masaki Kosugi, Hideaki Hisamoto, Shin Ichi Sasaki, Hirokazu Komatsu, Koji Suzuki

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Since lithium salts are used as pharmaceutically active compounds against manic-depressive psychosis, there is a demand to monitor the lithium concentration in blood in the narrow range of 0.6-1.2 mM effectively and safely. Here we report on an optical sensor approach for the determination of Li +, based on the design and synthesis of a novel lithium fluoroionophore KLI-1 and its polymer immobilizable derivative KLI-2, and the application to an optode. The novel lithium fluoroionophores rely on a tetramethyl "blocking subunit" bearing 14-crown-4 as a Li +-selective binding site and 4-methylcoumarin as a fluorophore, intramolecularly connected to show ICT-type wavelength shift for ratiometric fluorescence measurements. The fluoroionophores showed high selectivity for Li+ with binding-induced blue shift in the fluorescence spectra, no response to major biological interfering cations (K+, Ca 2+, Mg2+), a selectivity of log kLi+,Na+ = -2.4 over Na+ in solution, and no response to pH in the range of pH 3-10. A hydrophilic optode membrane with KLI-2 immobilized also showed good selectivity for Li+, pH independence in the physiological range (pH 6-8), and fully reversible signal changes. KLI-1 and KLI-2 are excellent Li + fluorescent chemosensors that can be applied to quantitative measurements of lithium in clinical samples, although possible interference from Na+ has to be considered at the lower therapeutic level of Li +.

Original languageEnglish
Pages (from-to)1237-1242
Number of pages6
JournalAnalytical Chemistry
Volume79
Issue number3
DOIs
Publication statusPublished - 2007 Feb 1

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Lithium
Ions
Bearings (structural)
Fluorescence
Fluorophores
Optical sensors
Cations
Polymers
Blood
Salts
Binding Sites
Derivatives
Membranes
Wavelength

ASJC Scopus subject areas

  • Analytical Chemistry

Cite this

Citterio, D., Takeda, J., Kosugi, M., Hisamoto, H., Sasaki, S. I., Komatsu, H., & Suzuki, K. (2007). pH-independent fluorescent chemosensor for highly selective lithium ion sensing. Analytical Chemistry, 79(3), 1237-1242. https://doi.org/10.1021/ac061674g

pH-independent fluorescent chemosensor for highly selective lithium ion sensing. / Citterio, Daniel; Takeda, Junichiro; Kosugi, Masaki; Hisamoto, Hideaki; Sasaki, Shin Ichi; Komatsu, Hirokazu; Suzuki, Koji.

In: Analytical Chemistry, Vol. 79, No. 3, 01.02.2007, p. 1237-1242.

Research output: Contribution to journalArticle

Citterio, D, Takeda, J, Kosugi, M, Hisamoto, H, Sasaki, SI, Komatsu, H & Suzuki, K 2007, 'pH-independent fluorescent chemosensor for highly selective lithium ion sensing', Analytical Chemistry, vol. 79, no. 3, pp. 1237-1242. https://doi.org/10.1021/ac061674g
Citterio, Daniel ; Takeda, Junichiro ; Kosugi, Masaki ; Hisamoto, Hideaki ; Sasaki, Shin Ichi ; Komatsu, Hirokazu ; Suzuki, Koji. / pH-independent fluorescent chemosensor for highly selective lithium ion sensing. In: Analytical Chemistry. 2007 ; Vol. 79, No. 3. pp. 1237-1242.
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