TY - JOUR
T1 - pH-Responsive Tunable Mixed-Charge Polymers for pH-Selective Interaction with Anionic Biological Constituents
AU - Hiruta, Yuki
AU - Sawada, Kazuki
AU - Mizui, Yuki
AU - Citterio, Daniel
N1 - Funding Information:
This study was supported by a Grant-in Aid for Early-Career Scientists (Grant No. 19K16339), and Nakatani Foundation Grant Program for Biomedical Engineering Research to Y.H.
Publisher Copyright:
© 2020 Chemical Society of Japan. All rights reserved.
PY - 2020
Y1 - 2020
N2 - A pH-responsive mixed-charge polymer consists of uniformly distributed cationic and anionic units in the polymer chain. Carboxylic acid monomers are generally used as anionic monomers. The pH responsive range is confined to a relatively narrow pH of Â5, which is limiting the biological application of pH-responsive polymers. Therefore, we investigated the effect of a series of carboxylic acid and neutral monomers on the pKa value of pH-responsive mixed-charge polymers. We synthesized the polymers using [2-(methacryloyloxy)ethyl]-trimethylammonium chloride, carboxylic acid monomers, and neutral monomers as the spacer moiety. As the monomer hydrophobicity and the composition ratio of neutral monomers increased, the pKa shifted to higher values. Finally, the polymer pKa values were tuned from 4.6 to 6.1. We confirmed that the pH-dependent interaction between anionic tissue constituent and pH-responsive mixed-charge polymers depends on their pKa.
AB - A pH-responsive mixed-charge polymer consists of uniformly distributed cationic and anionic units in the polymer chain. Carboxylic acid monomers are generally used as anionic monomers. The pH responsive range is confined to a relatively narrow pH of Â5, which is limiting the biological application of pH-responsive polymers. Therefore, we investigated the effect of a series of carboxylic acid and neutral monomers on the pKa value of pH-responsive mixed-charge polymers. We synthesized the polymers using [2-(methacryloyloxy)ethyl]-trimethylammonium chloride, carboxylic acid monomers, and neutral monomers as the spacer moiety. As the monomer hydrophobicity and the composition ratio of neutral monomers increased, the pKa shifted to higher values. Finally, the polymer pKa values were tuned from 4.6 to 6.1. We confirmed that the pH-dependent interaction between anionic tissue constituent and pH-responsive mixed-charge polymers depends on their pKa.
KW - Tunable responsive ph j mixed-charge polymer j ph-dependent adsorption
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U2 - 10.1246/BCSJ.20190374
DO - 10.1246/BCSJ.20190374
M3 - Article
AN - SCOPUS:85094822103
SN - 0009-2673
VL - 93
SP - 547
EP - 552
JO - Bulletin of the Chemical Society of Japan
JF - Bulletin of the Chemical Society of Japan
IS - 4
ER -