Pharmaceutical implications of curcumin in the development of drugs for cf pharmacotherapy: Combined effects with genistein

Yoshiro Sohma, Ying chun Yu, Haruna Miki, Yumi Nakamura, Akiko Hanyuda, Hui Yi Lin, Masato Yasui, Silvia Bompadre, Tzyh Chang Hwang

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The Cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel plays an essential role in salt and water transport across epithelia and mutations of CFTR causing its dysfunction result in the genetic disease cystic fibrosis (CF). Various mutations induce CFTR channel dysfunction and various pharmacological approaches are currently being explored. The G551D mutation in CFTR is a common cause of CF, characterized by an extremely low open probability despite its normal trafficking to the plasma membrane. Recently we investigated the potentiation effect of curcumin, especially its combined effect with a flavonoid genistein, on G551D-CFTR activity using the patch-clamp technique. Curcumin potentiated G551D-CFTR less than genistein at their maximally effective concentrations. However, curcumin showed an additive effect with genistein and, more importantly, a significant synergistic effect with genistein in a low concentration range. This does not only suggest that multiple mechanisms are involved in action of the CFTR potentiators, but also pose pharmaceutical implications of curcumin in the development of drugs for CF pharmacotherpy.

Original languageEnglish
Title of host publicationCurcumin
Subtitle of host publicationBiosynthesis, Medicinal Uses and Health Benefits
PublisherNova Science Publishers, Inc.
Pages223-234
Number of pages12
ISBN (Print)9781619424814
Publication statusPublished - 2012 Feb 1

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)

Fingerprint Dive into the research topics of 'Pharmaceutical implications of curcumin in the development of drugs for cf pharmacotherapy: Combined effects with genistein'. Together they form a unique fingerprint.

  • Cite this

    Sohma, Y., Yu, Y. C., Miki, H., Nakamura, Y., Hanyuda, A., Lin, H. Y., Yasui, M., Bompadre, S., & Hwang, T. C. (2012). Pharmaceutical implications of curcumin in the development of drugs for cf pharmacotherapy: Combined effects with genistein. In Curcumin: Biosynthesis, Medicinal Uses and Health Benefits (pp. 223-234). Nova Science Publishers, Inc..