Abstract
S-1108 in granules, a new oral cephem antibiotic, was pharmacokinetically and clinically evaluated in the pediatric field and the following results were obtained. 1. Pharmacokinetics S-1108 was administered at single doses of 2, 3, 4, 6 mg/kg orally and the following results were obtained on Cmax, T 1/2 and AUC, respectively: Cmax: 0.79, 1.03, 1.39, 1.06 µg/ml, T 1/2: 1.28 ±0.40, 1.27±0.65, 1.10±0.29, 1.83 hrs., AUC: 2.65±0.63, 3.99±2.77, 5.25±1.83, 5.15 µg·hr/ml. These values indicated a dose-dependent pharmacokinetic behavior. Urinary recovery rates were 12.5-30.0% in the first 8(6) hours after administration. 2. Clinical results The clinical efficacy of S-1108 was evaluated in 456 patients with various infections. S-1108 was administered at a dose of 2–4mg/kg three time a day to most patients. The overall clinical efficacy rate was 95.0%. In 294 cases with identified causative pathogen, the clinical efficacy rate was 96.9%, and the bacteriological eradication rate was 89.0%. Side effects occurred in 18 (3.23%) of 558 patients subjected to safety analyses. The main side effect was diarrhea but those side effects were mild and reversible. Abnormal laboratory test results were observed in 25 cases, (eosinophilia and elevated GOT and GPT). These abnormalities were not dose-dependent and also seen with other cephems to a similar extent. No particular and serious problems were associated with administration of this drug. Based on the above results, S-1108 is considered to be very useful at a standard dose of 2–4 mg/kg t.i.d. against most infections encountered in the pediatric field out-patient clinic.
Original language | English |
---|---|
Pages (from-to) | 921-941 |
Number of pages | 21 |
Journal | the japanese journal of antibiotics |
Volume | 48 |
Issue number | 7 |
DOIs | |
Publication status | Published - 1995 Jul |
Externally published | Yes |
ASJC Scopus subject areas
- Microbiology (medical)
- Pharmacology (medical)
- Infectious Diseases
Access to Document
Other files and links
Fingerprint
Dive into the research topics of 'Pharmacokinetic and clinical studies of s-1108 in the pediatric field'. Together they form a unique fingerprint.Cite this
- APA
- Standard
- Harvard
- Vancouver
- Author
- BIBTEX
- RIS
Pharmacokinetic and clinical studies of s-1108 in the pediatric field. / Fujii, Ryochi; Abe, Toshiaki; Tajima, Takeshi; Terashima, Itaru; Meguro, Hidenori; Mori, Atsuo; Sato, Hajime; Niino, Kenji; Sato, Hajime; Niino, Kenji; Sunakawa, Keisuke; Yokota, Takao; Akita, Hironobu; Iwata, Satoshi; Satoh, Yoshitake; Sunakawa, Keisuke; Yokota, Takao; Akita, Hironobu; Iwata, Satoshi; Satoh, Yoshitake; Sunakawa, Keisuke; Yokota, Takao; Akita, Hironobu; Iwata, Satoshi; Satoh, Yoshitake; Sunakawa, Keisuke; Yokota, Takao; Akita, Hironobu; Iwata, Satoshi; Satoh, Yoshitake; Toyonaga, Yoshikiyo; Ishihara, Toshihide; Sano, Tomoaki; Nakamura, Hironori; Toyonaga, Yoshikiyo; Ishihara, Toshihide; Sano, Tomoaki; Nakamura, Hironori; Iwai, Naoichi; Nakamura, Haruhi; Miyazu, Mitsunobu; Watanabe, Yumi; Kuno, Kuniyoshi; Kamiya, Hitoshi; Kitamura, Kenji; Ihara, Toshiaki; Sakurai, Minoru; Azuma, Eiichi; Itoh, Masahiro; Kamiya, Hitoshi; Kitamura, Kenji; Ihara, Toshiaki; Sakurai, Minoru; Azuma, Eiichi; Itoh, Masahiro; Mikawa, Haruki; Kubota, Masaru; Momoi, Tohru; Hosoi, Susumu; Nakato, Hidekazu; Mikawa, Haruki; Kubota, Masaru; Momoi, Tohru; Hosoi, Susumu; Nakato, Hidekazu; Mikawa, Haruki; Kubota, Masaru; Momoi, Tohru; Hosoi, Susumu; Nakato, Hidekazu; Nishimura, Tadafumi; Sugita, Kumiko; Aoki, Shigeyuki; Takagi, Michio; Nishimura, Tadafumi; Sugita, Kumiko; Aoki, Shigeyuki; Takagi, Michio; Nishimura, Tadafumi; Sugita, Kumiko; Aoki, Shigeyuki; Takagi, Michio; Kobayashi, Yohnosuke; Higashi, Hirohiko; Kino, Minoru; Kobayashi, Yutaka; Haruta, Tsunekazu; Kuroki, Shigekazu; Okura, Kan etsu; Okada, Takashige; Furukawa, Seikyo; Kuroda, Yasuhiro; Takeda, Eiji; Ito, Michinori; Matsuda, Hiroshi; Ishikawa, Junichi; Kida, Kaichi; Murase, Mitsuharu; Matsuda, Hiroshi; Ishikawa, Junichi; Kida, Kaichi; Murase, Mitsuharu; Kurashige, Takanobu; Morita, Hideo; Morisawa, Yutaka; Hamada, Fumihiko; Tsuji, Yoshiro; Yokoo, Tetsuya; Hayashi, Katsutoshi; Tomimasu, Kunio; Kido, Toshihiko; Uehara, Yutaka; Mori, Junko; Mori, Goichi; Uchida, Tetsuya; Ootsuka, Yuichi; Tsuji, Yoshiro; Yokoo, Tetsuya; Hayashi, Katsutoshi; Tomimasu, Kunio; Kido, Toshihiko; Uehara, Yutaka; Mori, Junko; Mori, Goichi; Uchida, Tetsuya; Ootsuka, Yuichi; Tsuji, Yoshiro; Yokoo, Tetsuya; Hayashi, Katsutoshi; Tomimasu, Kunio; Kido, Toshihiko; Uehara, Yutaka; Mori, Junko; Mori, Goichi; Uchida, Tetsuya; Ootsuka, Yuichi; Tsuji, Yoshiro; Yokoo, Tetsuya; Hayashi, Katsutoshi; Tomimasu, Kunio; Kido, Toshihiko; Uehara, Yutaka; Mori, Junko; Mori, Goichi; Uchida, Tetsuya; Ootsuka, Yuichi; Motohiro, Takashi; Handa, Shoichi; Yamada, Shuji; Oki, Shin ichiro; Yoshinaga, Yoichiro; Aramaki, Masafumi; Oda, Keiko; Sakata, Yasutaka; Kato, Hirohisa; Yamashita, Fumio; Imai, Shoichi; Suzuki, Kazushige; Okabayashi, Sayuri; Kaneko, Shinya; Ichikawa, Kotaro; Soda, Hiroko; Shimizu, Toko; Nagata, Yoichi; Kiba, Marie; Ishibashi, Shinsaku; Takahashi, Koichi; Sugiyama, Amiko; Miyake, Takumi; Araki, Hisaaki; Kakisako, Mitsuo; Maeno, Yasuki; Shimohida, Tsuyoshi; Takagishi, Tomoya; Matsukuma, Yoshinori; Hirata, Tomoshige; Tanaka, Nobuo; Nagayama, Kiyotaka; Yasuoka, Chikai; Hayashi, Masao; Amamoto, Masano; Tsumura, Naoki; Ono, Eiichiro; Kamizono, Shintaro; Nakashima, Eisuke; Nagamitsu, Shinichiro; Nomasa, Takayo; Matsuo, Yusaku; Higuchi, Emi; Nagai, Kensuke; Sueyoshi, Keiko; Hashimoto, Nobuo; Yuge, Ken; Kubota, Kaoru; Kawakami, Akira; Watanabe, Yoriko; Fujisawa, Takuji; Nishiyama, Toru; Iwanaga, Rikako; Ushijima, Kosuke; Yamakawa, Ryoichi; Yamamura, Jyunichi; Tominaga, Kaoru; Dai, Syunichi; Ando, Hiroshi; Kuda, Naoki; Fujimoto, Tamotsu; Motoyama, Hirotaka; Maruoka, Takayuki; Date, Yukiji; Sugimura, Toru; Nishiyori, Sunao; Asakino, Yuki; Yamada, Katsuhiko; Kotematsu, Seigo; Hayakawa, Hiroshi; Sasaki, Hirokazu; Kimura, Koichi; Yamada, Takashi.
In: the japanese journal of antibiotics, Vol. 48, No. 7, 07.1995, p. 921-941.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Pharmacokinetic and clinical studies of s-1108 in the pediatric field
AU - Fujii, Ryochi
AU - Abe, Toshiaki
AU - Tajima, Takeshi
AU - Terashima, Itaru
AU - Meguro, Hidenori
AU - Mori, Atsuo
AU - Sato, Hajime
AU - Niino, Kenji
AU - Sato, Hajime
AU - Niino, Kenji
AU - Sunakawa, Keisuke
AU - Yokota, Takao
AU - Akita, Hironobu
AU - Iwata, Satoshi
AU - Satoh, Yoshitake
AU - Sunakawa, Keisuke
AU - Yokota, Takao
AU - Akita, Hironobu
AU - Iwata, Satoshi
AU - Satoh, Yoshitake
AU - Sunakawa, Keisuke
AU - Yokota, Takao
AU - Akita, Hironobu
AU - Iwata, Satoshi
AU - Satoh, Yoshitake
AU - Sunakawa, Keisuke
AU - Yokota, Takao
AU - Akita, Hironobu
AU - Iwata, Satoshi
AU - Satoh, Yoshitake
AU - Toyonaga, Yoshikiyo
AU - Ishihara, Toshihide
AU - Sano, Tomoaki
AU - Nakamura, Hironori
AU - Toyonaga, Yoshikiyo
AU - Ishihara, Toshihide
AU - Sano, Tomoaki
AU - Nakamura, Hironori
AU - Iwai, Naoichi
AU - Nakamura, Haruhi
AU - Miyazu, Mitsunobu
AU - Watanabe, Yumi
AU - Kuno, Kuniyoshi
AU - Kamiya, Hitoshi
AU - Kitamura, Kenji
AU - Ihara, Toshiaki
AU - Sakurai, Minoru
AU - Azuma, Eiichi
AU - Itoh, Masahiro
AU - Kamiya, Hitoshi
AU - Kitamura, Kenji
AU - Ihara, Toshiaki
AU - Sakurai, Minoru
AU - Azuma, Eiichi
AU - Itoh, Masahiro
AU - Mikawa, Haruki
AU - Kubota, Masaru
AU - Momoi, Tohru
AU - Hosoi, Susumu
AU - Nakato, Hidekazu
AU - Mikawa, Haruki
AU - Kubota, Masaru
AU - Momoi, Tohru
AU - Hosoi, Susumu
AU - Nakato, Hidekazu
AU - Mikawa, Haruki
AU - Kubota, Masaru
AU - Momoi, Tohru
AU - Hosoi, Susumu
AU - Nakato, Hidekazu
AU - Nishimura, Tadafumi
AU - Sugita, Kumiko
AU - Aoki, Shigeyuki
AU - Takagi, Michio
AU - Nishimura, Tadafumi
AU - Sugita, Kumiko
AU - Aoki, Shigeyuki
AU - Takagi, Michio
AU - Nishimura, Tadafumi
AU - Sugita, Kumiko
AU - Aoki, Shigeyuki
AU - Takagi, Michio
AU - Kobayashi, Yohnosuke
AU - Higashi, Hirohiko
AU - Kino, Minoru
AU - Kobayashi, Yutaka
AU - Haruta, Tsunekazu
AU - Kuroki, Shigekazu
AU - Okura, Kan etsu
AU - Okada, Takashige
AU - Furukawa, Seikyo
AU - Kuroda, Yasuhiro
AU - Takeda, Eiji
AU - Ito, Michinori
AU - Matsuda, Hiroshi
AU - Ishikawa, Junichi
AU - Kida, Kaichi
AU - Murase, Mitsuharu
AU - Matsuda, Hiroshi
AU - Ishikawa, Junichi
AU - Kida, Kaichi
AU - Murase, Mitsuharu
AU - Kurashige, Takanobu
AU - Morita, Hideo
AU - Morisawa, Yutaka
AU - Hamada, Fumihiko
AU - Tsuji, Yoshiro
AU - Yokoo, Tetsuya
AU - Hayashi, Katsutoshi
AU - Tomimasu, Kunio
AU - Kido, Toshihiko
AU - Uehara, Yutaka
AU - Mori, Junko
AU - Mori, Goichi
AU - Uchida, Tetsuya
AU - Ootsuka, Yuichi
AU - Tsuji, Yoshiro
AU - Yokoo, Tetsuya
AU - Hayashi, Katsutoshi
AU - Tomimasu, Kunio
AU - Kido, Toshihiko
AU - Uehara, Yutaka
AU - Mori, Junko
AU - Mori, Goichi
AU - Uchida, Tetsuya
AU - Ootsuka, Yuichi
AU - Tsuji, Yoshiro
AU - Yokoo, Tetsuya
AU - Hayashi, Katsutoshi
AU - Tomimasu, Kunio
AU - Kido, Toshihiko
AU - Uehara, Yutaka
AU - Mori, Junko
AU - Mori, Goichi
AU - Uchida, Tetsuya
AU - Ootsuka, Yuichi
AU - Tsuji, Yoshiro
AU - Yokoo, Tetsuya
AU - Hayashi, Katsutoshi
AU - Tomimasu, Kunio
AU - Kido, Toshihiko
AU - Uehara, Yutaka
AU - Mori, Junko
AU - Mori, Goichi
AU - Uchida, Tetsuya
AU - Ootsuka, Yuichi
AU - Motohiro, Takashi
AU - Handa, Shoichi
AU - Yamada, Shuji
AU - Oki, Shin ichiro
AU - Yoshinaga, Yoichiro
AU - Aramaki, Masafumi
AU - Oda, Keiko
AU - Sakata, Yasutaka
AU - Kato, Hirohisa
AU - Yamashita, Fumio
AU - Imai, Shoichi
AU - Suzuki, Kazushige
AU - Okabayashi, Sayuri
AU - Kaneko, Shinya
AU - Ichikawa, Kotaro
AU - Soda, Hiroko
AU - Shimizu, Toko
AU - Nagata, Yoichi
AU - Kiba, Marie
AU - Ishibashi, Shinsaku
AU - Takahashi, Koichi
AU - Sugiyama, Amiko
AU - Miyake, Takumi
AU - Araki, Hisaaki
AU - Kakisako, Mitsuo
AU - Maeno, Yasuki
AU - Shimohida, Tsuyoshi
AU - Takagishi, Tomoya
AU - Matsukuma, Yoshinori
AU - Hirata, Tomoshige
AU - Tanaka, Nobuo
AU - Nagayama, Kiyotaka
AU - Yasuoka, Chikai
AU - Hayashi, Masao
AU - Amamoto, Masano
AU - Tsumura, Naoki
AU - Ono, Eiichiro
AU - Kamizono, Shintaro
AU - Nakashima, Eisuke
AU - Nagamitsu, Shinichiro
AU - Nomasa, Takayo
AU - Matsuo, Yusaku
AU - Higuchi, Emi
AU - Nagai, Kensuke
AU - Sueyoshi, Keiko
AU - Hashimoto, Nobuo
AU - Yuge, Ken
AU - Kubota, Kaoru
AU - Kawakami, Akira
AU - Watanabe, Yoriko
AU - Fujisawa, Takuji
AU - Nishiyama, Toru
AU - Iwanaga, Rikako
AU - Ushijima, Kosuke
AU - Yamakawa, Ryoichi
AU - Yamamura, Jyunichi
AU - Tominaga, Kaoru
AU - Dai, Syunichi
AU - Ando, Hiroshi
AU - Kuda, Naoki
AU - Fujimoto, Tamotsu
AU - Motoyama, Hirotaka
AU - Maruoka, Takayuki
AU - Date, Yukiji
AU - Sugimura, Toru
AU - Nishiyori, Sunao
AU - Asakino, Yuki
AU - Yamada, Katsuhiko
AU - Kotematsu, Seigo
AU - Hayakawa, Hiroshi
AU - Sasaki, Hirokazu
AU - Kimura, Koichi
AU - Yamada, Takashi
PY - 1995/7
Y1 - 1995/7
N2 - S-1108 in granules, a new oral cephem antibiotic, was pharmacokinetically and clinically evaluated in the pediatric field and the following results were obtained. 1. Pharmacokinetics S-1108 was administered at single doses of 2, 3, 4, 6 mg/kg orally and the following results were obtained on Cmax, T 1/2 and AUC, respectively: Cmax: 0.79, 1.03, 1.39, 1.06 µg/ml, T 1/2: 1.28 ±0.40, 1.27±0.65, 1.10±0.29, 1.83 hrs., AUC: 2.65±0.63, 3.99±2.77, 5.25±1.83, 5.15 µg·hr/ml. These values indicated a dose-dependent pharmacokinetic behavior. Urinary recovery rates were 12.5-30.0% in the first 8(6) hours after administration. 2. Clinical results The clinical efficacy of S-1108 was evaluated in 456 patients with various infections. S-1108 was administered at a dose of 2–4mg/kg three time a day to most patients. The overall clinical efficacy rate was 95.0%. In 294 cases with identified causative pathogen, the clinical efficacy rate was 96.9%, and the bacteriological eradication rate was 89.0%. Side effects occurred in 18 (3.23%) of 558 patients subjected to safety analyses. The main side effect was diarrhea but those side effects were mild and reversible. Abnormal laboratory test results were observed in 25 cases, (eosinophilia and elevated GOT and GPT). These abnormalities were not dose-dependent and also seen with other cephems to a similar extent. No particular and serious problems were associated with administration of this drug. Based on the above results, S-1108 is considered to be very useful at a standard dose of 2–4 mg/kg t.i.d. against most infections encountered in the pediatric field out-patient clinic.
AB - S-1108 in granules, a new oral cephem antibiotic, was pharmacokinetically and clinically evaluated in the pediatric field and the following results were obtained. 1. Pharmacokinetics S-1108 was administered at single doses of 2, 3, 4, 6 mg/kg orally and the following results were obtained on Cmax, T 1/2 and AUC, respectively: Cmax: 0.79, 1.03, 1.39, 1.06 µg/ml, T 1/2: 1.28 ±0.40, 1.27±0.65, 1.10±0.29, 1.83 hrs., AUC: 2.65±0.63, 3.99±2.77, 5.25±1.83, 5.15 µg·hr/ml. These values indicated a dose-dependent pharmacokinetic behavior. Urinary recovery rates were 12.5-30.0% in the first 8(6) hours after administration. 2. Clinical results The clinical efficacy of S-1108 was evaluated in 456 patients with various infections. S-1108 was administered at a dose of 2–4mg/kg three time a day to most patients. The overall clinical efficacy rate was 95.0%. In 294 cases with identified causative pathogen, the clinical efficacy rate was 96.9%, and the bacteriological eradication rate was 89.0%. Side effects occurred in 18 (3.23%) of 558 patients subjected to safety analyses. The main side effect was diarrhea but those side effects were mild and reversible. Abnormal laboratory test results were observed in 25 cases, (eosinophilia and elevated GOT and GPT). These abnormalities were not dose-dependent and also seen with other cephems to a similar extent. No particular and serious problems were associated with administration of this drug. Based on the above results, S-1108 is considered to be very useful at a standard dose of 2–4 mg/kg t.i.d. against most infections encountered in the pediatric field out-patient clinic.
UR - http://www.scopus.com/inward/record.url?scp=0029027061&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029027061&partnerID=8YFLogxK
U2 - 10.11553/antibiotics1968b.48.921
DO - 10.11553/antibiotics1968b.48.921
M3 - Article
C2 - 7563586
AN - SCOPUS:0029027061
VL - 48
SP - 921
EP - 941
JO - The Journal of antibiotics. Ser. B
JF - The Journal of antibiotics. Ser. B
SN - 0368-2781
IS - 7
ER -