Pharmacokinetic and clinical studies of s-1108 in the pediatric field

Ryochi Fujii; Toshiaki Abe; Takeshi Tajima; Itaru Terashima; Hidenori Meguro; Atsuo Mori; Hajime Sato; Kenji Niino; Hajime Sato; Kenji Niino; Keisuke Sunakawa; Takao Yokota; Hironobu Akita; Satoshi Iwata; Yoshitake Satoh; Keisuke Sunakawa; Takao Yokota; Hironobu Akita; Satoshi Iwata; Yoshitake Satoh; Keisuke Sunakawa; Takao Yokota; Hironobu Akita; Satoshi Iwata; Yoshitake Satoh; Keisuke Sunakawa; Takao Yokota; Hironobu Akita; Satoshi Iwata; Yoshitake Satoh; Yoshikiyo Toyonaga; Toshihide Ishihara; Tomoaki Sano; Hironori Nakamura; Yoshikiyo Toyonaga; Toshihide Ishihara; Tomoaki Sano; Hironori Nakamura; Naoichi Iwai; Haruhi Nakamura; Mitsunobu Miyazu; Yumi Watanabe; Kuniyoshi Kuno; Hitoshi Kamiya; Kenji Kitamura; Toshiaki Ihara; Minoru Sakurai; Eiichi Azuma; Masahiro Itoh; Hitoshi Kamiya; Kenji Kitamura; Toshiaki Ihara; Minoru Sakurai; Eiichi Azuma; Masahiro Itoh; Haruki Mikawa; Masaru Kubota; Tohru Momoi; Susumu Hosoi; Hidekazu Nakato; Haruki Mikawa; Masaru Kubota; Tohru Momoi; Susumu Hosoi; Hidekazu Nakato; Haruki Mikawa; Masaru Kubota; Tohru Momoi; Susumu Hosoi; Hidekazu Nakato; Tadafumi Nishimura; Kumiko Sugita; Shigeyuki Aoki; Michio Takagi; Tadafumi Nishimura; Kumiko Sugita; Shigeyuki Aoki; Michio Takagi; Tadafumi Nishimura; Kumiko Sugita; Shigeyuki Aoki; Michio Takagi; Yohnosuke Kobayashi; Hirohiko Higashi; Minoru Kino; Yutaka Kobayashi; Tsunekazu Haruta; Shigekazu Kuroki; Kan etsu Okura; Takashige Okada; Seikyo Furukawa; Yasuhiro Kuroda; Eiji Takeda; Michinori Ito; Hiroshi Matsuda; Junichi Ishikawa; Kaichi Kida; Mitsuharu Murase; Hiroshi Matsuda; Junichi Ishikawa; Kaichi Kida; Mitsuharu Murase; Takanobu Kurashige; Hideo Morita; Yutaka Morisawa; Fumihiko Hamada; Yoshiro Tsuji; Tetsuya Yokoo; Katsutoshi Hayashi; Kunio Tomimasu; Toshihiko Kido; Yutaka Uehara; Junko Mori; Goichi Mori; Tetsuya Uchida; Yuichi Ootsuka; Yoshiro Tsuji; Tetsuya Yokoo; Katsutoshi Hayashi; Kunio Tomimasu; Toshihiko Kido; Yutaka Uehara; Junko Mori; Goichi Mori; Tetsuya Uchida; Yuichi Ootsuka; Yoshiro Tsuji; Tetsuya Yokoo; Katsutoshi Hayashi; Kunio Tomimasu; Toshihiko Kido; Yutaka Uehara; Junko Mori; Goichi Mori; Tetsuya Uchida; Yuichi Ootsuka; Yoshiro Tsuji; Tetsuya Yokoo; Katsutoshi Hayashi; Kunio Tomimasu; Toshihiko Kido; Yutaka Uehara; Junko Mori; Goichi Mori; Tetsuya Uchida; Yuichi Ootsuka; Takashi Motohiro; Shoichi Handa; Shuji Yamada; Shin ichiro Oki; Yoichiro Yoshinaga; Masafumi Aramaki; Keiko Oda; Yasutaka Sakata; Hirohisa Kato; Fumio Yamashita; Shoichi Imai; Kazushige Suzuki; Sayuri Okabayashi; Shinya Kaneko; Kotaro Ichikawa; Hiroko Soda; Toko Shimizu; Yoichi Nagata; Marie Kiba; Shinsaku Ishibashi; Koichi Takahashi; Amiko Sugiyama; Takumi Miyake; Hisaaki Araki; Mitsuo Kakisako; Yasuki Maeno; Tsuyoshi Shimohida; Tomoya Takagishi; Yoshinori Matsukuma; Tomoshige Hirata; Nobuo Tanaka; Kiyotaka Nagayama; Chikai Yasuoka; Masao Hayashi; Masano Amamoto; Naoki Tsumura; Eiichiro Ono; Shintaro Kamizono; Eisuke Nakashima; Shinichiro Nagamitsu; Takayo Nomasa; Yusaku Matsuo; Emi Higuchi; Kensuke Nagai; Keiko Sueyoshi; Nobuo Hashimoto; Ken Yuge; Kaoru Kubota; Akira Kawakami; Yoriko Watanabe; Takuji Fujisawa; Toru Nishiyama; Rikako Iwanaga; Kosuke Ushijima; Ryoichi Yamakawa; Jyunichi Yamamura; Kaoru Tominaga; Syunichi Dai; Hiroshi Ando; Naoki Kuda; Tamotsu Fujimoto; Hirotaka Motoyama; Takayuki Maruoka; Yukiji Date; Toru Sugimura; Sunao Nishiyori; Yuki Asakino; Katsuhiko Yamada; Seigo Kotematsu; Hiroshi Hayakawa; Hirokazu Sasaki; Koichi Kimura; Takashi Yamada

doi:10.11553/antibiotics1968b.48.921

Pharmacokinetic and clinical studies of s-1108 in the pediatric field

Ryochi Fujii, Toshiaki Abe, Takeshi Tajima, Itaru Terashima, Hidenori Meguro, Atsuo Mori, Hajime Sato, Kenji Niino, Hajime Sato, Kenji Niino, Keisuke Sunakawa, Takao Yokota, Hironobu Akita, Satoshi Iwata, Yoshitake Satoh, Keisuke Sunakawa, Takao Yokota, Hironobu Akita, Satoshi Iwata, Yoshitake SatohKeisuke Sunakawa, Takao Yokota, Hironobu Akita, Satoshi Iwata, Yoshitake Satoh, Keisuke Sunakawa, Takao Yokota, Hironobu Akita, Satoshi Iwata, Yoshitake Satoh, Yoshikiyo Toyonaga, Toshihide Ishihara, Tomoaki Sano, Hironori Nakamura, Yoshikiyo Toyonaga, Toshihide Ishihara, Tomoaki Sano, Hironori Nakamura, Naoichi Iwai, Haruhi Nakamura, Mitsunobu Miyazu, Yumi Watanabe, Kuniyoshi Kuno, Hitoshi Kamiya, Kenji Kitamura, Toshiaki Ihara, Minoru Sakurai, Eiichi Azuma, Masahiro Itoh, Hitoshi Kamiya, Kenji Kitamura, Toshiaki Ihara, Minoru Sakurai, Eiichi Azuma, Masahiro Itoh, Haruki Mikawa, Masaru Kubota, Tohru Momoi, Susumu Hosoi, Hidekazu Nakato, Haruki Mikawa, Masaru Kubota, Tohru Momoi, Susumu Hosoi, Hidekazu Nakato, Haruki Mikawa, Masaru Kubota, Tohru Momoi, Susumu Hosoi, Hidekazu Nakato, Tadafumi Nishimura, Kumiko Sugita, Shigeyuki Aoki, Michio Takagi, Tadafumi Nishimura, Kumiko Sugita, Shigeyuki Aoki, Michio Takagi, Tadafumi Nishimura, Kumiko Sugita, Shigeyuki Aoki, Michio Takagi, Yohnosuke Kobayashi, Hirohiko Higashi, Minoru Kino, Yutaka Kobayashi, Tsunekazu Haruta, Shigekazu Kuroki, Kan etsu Okura, Takashige Okada, Seikyo Furukawa, Yasuhiro Kuroda, Eiji Takeda, Michinori Ito, Hiroshi Matsuda, Junichi Ishikawa, Kaichi Kida, Mitsuharu Murase, Hiroshi Matsuda, Junichi Ishikawa, Kaichi Kida, Mitsuharu Murase, Takanobu Kurashige, Hideo Morita, Yutaka Morisawa, Fumihiko Hamada, Yoshiro Tsuji, Tetsuya Yokoo, Katsutoshi Hayashi, Kunio Tomimasu, Toshihiko Kido, Yutaka Uehara, Junko Mori, Goichi Mori, Tetsuya Uchida, Yuichi Ootsuka, Yoshiro Tsuji, Tetsuya Yokoo, Katsutoshi Hayashi, Kunio Tomimasu, Toshihiko Kido, Yutaka Uehara, Junko Mori, Goichi Mori, Tetsuya Uchida, Yuichi Ootsuka, Yoshiro Tsuji, Tetsuya Yokoo, Katsutoshi Hayashi, Kunio Tomimasu, Toshihiko Kido, Yutaka Uehara, Junko Mori, Goichi Mori, Tetsuya Uchida, Yuichi Ootsuka, Yoshiro Tsuji, Tetsuya Yokoo, Katsutoshi Hayashi, Kunio Tomimasu, Toshihiko Kido, Yutaka Uehara, Junko Mori, Goichi Mori, Tetsuya Uchida, Yuichi Ootsuka, Takashi Motohiro, Shoichi Handa, Shuji Yamada, Shin ichiro Oki, Yoichiro Yoshinaga, Masafumi Aramaki, Keiko Oda, Yasutaka Sakata, Hirohisa Kato, Fumio Yamashita, Shoichi Imai, Kazushige Suzuki, Sayuri Okabayashi, Shinya Kaneko, Kotaro Ichikawa, Hiroko Soda, Toko Shimizu, Yoichi Nagata, Marie Kiba, Shinsaku Ishibashi, Koichi Takahashi, Amiko Sugiyama, Takumi Miyake, Hisaaki Araki, Mitsuo Kakisako, Yasuki Maeno, Tsuyoshi Shimohida, Tomoya Takagishi, Yoshinori Matsukuma, Tomoshige Hirata, Nobuo Tanaka, Kiyotaka Nagayama, Chikai Yasuoka, Masao Hayashi, Masano Amamoto, Naoki Tsumura, Eiichiro Ono, Shintaro Kamizono, Eisuke Nakashima, Shinichiro Nagamitsu, Takayo Nomasa, Yusaku Matsuo, Emi Higuchi, Kensuke Nagai, Keiko Sueyoshi, Nobuo Hashimoto, Ken Yuge, Kaoru Kubota, Akira Kawakami, Yoriko Watanabe, Takuji Fujisawa, Toru Nishiyama, Rikako Iwanaga, Kosuke Ushijima, Ryoichi Yamakawa, Jyunichi Yamamura, Kaoru Tominaga, Syunichi Dai, Hiroshi Ando, Naoki Kuda, Tamotsu Fujimoto, Hirotaka Motoyama, Takayuki Maruoka, Yukiji Date, Toru Sugimura, Sunao Nishiyori, Yuki Asakino, Katsuhiko Yamada, Seigo Kotematsu, Hiroshi Hayakawa, Hirokazu Sasaki, Koichi Kimura, Takashi Yamada

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

S-1108 in granules, a new oral cephem antibiotic, was pharmacokinetically and clinically evaluated in the pediatric field and the following results were obtained. 1. Pharmacokinetics S-1108 was administered at single doses of 2, 3, 4, 6 mg/kg orally and the following results were obtained on C_max, T 1/2 and AUC, respectively: C_max: 0.79, 1.03, 1.39, 1.06 µg/ml, T 1/2: 1.28 ±0.40, 1.27±0.65, 1.10±0.29, 1.83 hrs., AUC: 2.65±0.63, 3.99±2.77, 5.25±1.83, 5.15 µg·hr/ml. These values indicated a dose-dependent pharmacokinetic behavior. Urinary recovery rates were 12.5-30.0% in the first 8(6) hours after administration. 2. Clinical results The clinical efficacy of S-1108 was evaluated in 456 patients with various infections. S-1108 was administered at a dose of 2–4mg/kg three time a day to most patients. The overall clinical efficacy rate was 95.0%. In 294 cases with identified causative pathogen, the clinical efficacy rate was 96.9%, and the bacteriological eradication rate was 89.0%. Side effects occurred in 18 (3.23%) of 558 patients subjected to safety analyses. The main side effect was diarrhea but those side effects were mild and reversible. Abnormal laboratory test results were observed in 25 cases, (eosinophilia and elevated GOT and GPT). These abnormalities were not dose-dependent and also seen with other cephems to a similar extent. No particular and serious problems were associated with administration of this drug. Based on the above results, S-1108 is considered to be very useful at a standard dose of 2–4 mg/kg t.i.d. against most infections encountered in the pediatric field out-patient clinic.

Original language	English
Pages (from-to)	921-941
Number of pages	21
Journal	the japanese journal of antibiotics
Volume	48
Issue number	7
DOIs	https://doi.org/10.11553/antibiotics1968b.48.921
Publication status	Published - 1995 Jul
Externally published	Yes

ASJC Scopus subject areas

Microbiology (medical)
Pharmacology (medical)
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.11553/antibiotics1968b.48.921

Cite this

Fujii, R., Abe, T., Tajima, T., Terashima, I., Meguro, H., Mori, A., Sato, H., Niino, K., Sato, H., Niino, K., Sunakawa, K., Yokota, T., Akita, H., Iwata, S., Satoh, Y., Sunakawa, K., Yokota, T., Akita, H., Iwata, S., ... Yamada, T. (1995). Pharmacokinetic and clinical studies of s-1108 in the pediatric field. the japanese journal of antibiotics, 48(7), 921-941. https://doi.org/10.11553/antibiotics1968b.48.921

Fujii, R, Abe, T, Tajima, T, Terashima, I, Meguro, H, Mori, A, Sato, H, Niino, K, Sato, H, Niino, K, Sunakawa, K, Yokota, T, Akita, H, Iwata, S, Satoh, Y, Sunakawa, K, Yokota, T, Akita, H, Iwata, S, Satoh, Y, Sunakawa, K, Yokota, T, Akita, H, Iwata, S, Satoh, Y, Sunakawa, K, Yokota, T, Akita, H, Iwata, S, Satoh, Y, Toyonaga, Y, Ishihara, T, Sano, T, Nakamura, H, Toyonaga, Y, Ishihara, T, Sano, T, Nakamura, H, Iwai, N, Nakamura, H, Miyazu, M, Watanabe, Y, Kuno, K, Kamiya, H, Kitamura, K, Ihara, T, Sakurai, M, Azuma, E, Itoh, M, Kamiya, H, Kitamura, K, Ihara, T, Sakurai, M, Azuma, E, Itoh, M, Mikawa, H, Kubota, M, Momoi, T, Hosoi, S, Nakato, H, Mikawa, H, Kubota, M, Momoi, T, Hosoi, S, Nakato, H, Mikawa, H, Kubota, M, Momoi, T, Hosoi, S, Nakato, H, Nishimura, T, Sugita, K, Aoki, S, Takagi, M, Nishimura, T, Sugita, K, Aoki, S, Takagi, M, Nishimura, T, Sugita, K, Aoki, S, Takagi, M, Kobayashi, Y, Higashi, H, Kino, M, Kobayashi, Y, Haruta, T, Kuroki, S, Okura, KE, Okada, T, Furukawa, S, Kuroda, Y, Takeda, E, Ito, M, Matsuda, H, Ishikawa, J, Kida, K, Murase, M, Matsuda, H, Ishikawa, J, Kida, K, Murase, M, Kurashige, T, Morita, H, Morisawa, Y, Hamada, F, Tsuji, Y, Yokoo, T, Hayashi, K, Tomimasu, K, Kido, T, Uehara, Y, Mori, J, Mori, G, Uchida, T, Ootsuka, Y, Tsuji, Y, Yokoo, T, Hayashi, K, Tomimasu, K, Kido, T, Uehara, Y, Mori, J, Mori, G, Uchida, T, Ootsuka, Y, Tsuji, Y, Yokoo, T, Hayashi, K, Tomimasu, K, Kido, T, Uehara, Y, Mori, J, Mori, G, Uchida, T, Ootsuka, Y, Tsuji, Y, Yokoo, T, Hayashi, K, Tomimasu, K, Kido, T, Uehara, Y, Mori, J, Mori, G, Uchida, T, Ootsuka, Y, Motohiro, T, Handa, S, Yamada, S, Oki, SI, Yoshinaga, Y, Aramaki, M, Oda, K, Sakata, Y, Kato, H, Yamashita, F, Imai, S, Suzuki, K, Okabayashi, S, Kaneko, S, Ichikawa, K, Soda, H, Shimizu, T, Nagata, Y, Kiba, M, Ishibashi, S, Takahashi, K, Sugiyama, A, Miyake, T, Araki, H, Kakisako, M, Maeno, Y, Shimohida, T, Takagishi, T, Matsukuma, Y, Hirata, T, Tanaka, N, Nagayama, K, Yasuoka, C, Hayashi, M, Amamoto, M, Tsumura, N, Ono, E, Kamizono, S, Nakashima, E, Nagamitsu, S, Nomasa, T, Matsuo, Y, Higuchi, E, Nagai, K, Sueyoshi, K, Hashimoto, N, Yuge, K, Kubota, K, Kawakami, A, Watanabe, Y, Fujisawa, T, Nishiyama, T, Iwanaga, R, Ushijima, K, Yamakawa, R, Yamamura, J, Tominaga, K, Dai, S, Ando, H, Kuda, N, Fujimoto, T, Motoyama, H, Maruoka, T, Date, Y, Sugimura, T, Nishiyori, S, Asakino, Y, Yamada, K, Kotematsu, S, Hayakawa, H, Sasaki, H, Kimura, K & Yamada, T 1995, 'Pharmacokinetic and clinical studies of s-1108 in the pediatric field', the japanese journal of antibiotics, vol. 48, no. 7, pp. 921-941. https://doi.org/10.11553/antibiotics1968b.48.921

@article{57ca519d0d93405593c60190ee6c72b2,

title = "Pharmacokinetic and clinical studies of s-1108 in the pediatric field",

abstract = "S-1108 in granules, a new oral cephem antibiotic, was pharmacokinetically and clinically evaluated in the pediatric field and the following results were obtained. 1. Pharmacokinetics S-1108 was administered at single doses of 2, 3, 4, 6 mg/kg orally and the following results were obtained on Cmax, T 1/2 and AUC, respectively: Cmax: 0.79, 1.03, 1.39, 1.06 µg/ml, T 1/2: 1.28 ±0.40, 1.27±0.65, 1.10±0.29, 1.83 hrs., AUC: 2.65±0.63, 3.99±2.77, 5.25±1.83, 5.15 µg·hr/ml. These values indicated a dose-dependent pharmacokinetic behavior. Urinary recovery rates were 12.5-30.0% in the first 8(6) hours after administration. 2. Clinical results The clinical efficacy of S-1108 was evaluated in 456 patients with various infections. S-1108 was administered at a dose of 2–4mg/kg three time a day to most patients. The overall clinical efficacy rate was 95.0%. In 294 cases with identified causative pathogen, the clinical efficacy rate was 96.9%, and the bacteriological eradication rate was 89.0%. Side effects occurred in 18 (3.23%) of 558 patients subjected to safety analyses. The main side effect was diarrhea but those side effects were mild and reversible. Abnormal laboratory test results were observed in 25 cases, (eosinophilia and elevated GOT and GPT). These abnormalities were not dose-dependent and also seen with other cephems to a similar extent. No particular and serious problems were associated with administration of this drug. Based on the above results, S-1108 is considered to be very useful at a standard dose of 2–4 mg/kg t.i.d. against most infections encountered in the pediatric field out-patient clinic.",

author = "Ryochi Fujii and Toshiaki Abe and Takeshi Tajima and Itaru Terashima and Hidenori Meguro and Atsuo Mori and Hajime Sato and Kenji Niino and Hajime Sato and Kenji Niino and Keisuke Sunakawa and Takao Yokota and Hironobu Akita and Satoshi Iwata and Yoshitake Satoh and Keisuke Sunakawa and Takao Yokota and Hironobu Akita and Satoshi Iwata and Yoshitake Satoh and Keisuke Sunakawa and Takao Yokota and Hironobu Akita and Satoshi Iwata and Yoshitake Satoh and Keisuke Sunakawa and Takao Yokota and Hironobu Akita and Satoshi Iwata and Yoshitake Satoh and Yoshikiyo Toyonaga and Toshihide Ishihara and Tomoaki Sano and Hironori Nakamura and Yoshikiyo Toyonaga and Toshihide Ishihara and Tomoaki Sano and Hironori Nakamura and Naoichi Iwai and Haruhi Nakamura and Mitsunobu Miyazu and Yumi Watanabe and Kuniyoshi Kuno and Hitoshi Kamiya and Kenji Kitamura and Toshiaki Ihara and Minoru Sakurai and Eiichi Azuma and Masahiro Itoh and Hitoshi Kamiya and Kenji Kitamura and Toshiaki Ihara and Minoru Sakurai and Eiichi Azuma and Masahiro Itoh and Haruki Mikawa and Masaru Kubota and Tohru Momoi and Susumu Hosoi and Hidekazu Nakato and Haruki Mikawa and Masaru Kubota and Tohru Momoi and Susumu Hosoi and Hidekazu Nakato and Haruki Mikawa and Masaru Kubota and Tohru Momoi and Susumu Hosoi and Hidekazu Nakato and Tadafumi Nishimura and Kumiko Sugita and Shigeyuki Aoki and Michio Takagi and Tadafumi Nishimura and Kumiko Sugita and Shigeyuki Aoki and Michio Takagi and Tadafumi Nishimura and Kumiko Sugita and Shigeyuki Aoki and Michio Takagi and Yohnosuke Kobayashi and Hirohiko Higashi and Minoru Kino and Yutaka Kobayashi and Tsunekazu Haruta and Shigekazu Kuroki and Okura, {Kan etsu} and Takashige Okada and Seikyo Furukawa and Yasuhiro Kuroda and Eiji Takeda and Michinori Ito and Hiroshi Matsuda and Junichi Ishikawa and Kaichi Kida and Mitsuharu Murase and Hiroshi Matsuda and Junichi Ishikawa and Kaichi Kida and Mitsuharu Murase and Takanobu Kurashige and Hideo Morita and Yutaka Morisawa and Fumihiko Hamada and Yoshiro Tsuji and Tetsuya Yokoo and Katsutoshi Hayashi and Kunio Tomimasu and Toshihiko Kido and Yutaka Uehara and Junko Mori and Goichi Mori and Tetsuya Uchida and Yuichi Ootsuka and Yoshiro Tsuji and Tetsuya Yokoo and Katsutoshi Hayashi and Kunio Tomimasu and Toshihiko Kido and Yutaka Uehara and Junko Mori and Goichi Mori and Tetsuya Uchida and Yuichi Ootsuka and Yoshiro Tsuji and Tetsuya Yokoo and Katsutoshi Hayashi and Kunio Tomimasu and Toshihiko Kido and Yutaka Uehara and Junko Mori and Goichi Mori and Tetsuya Uchida and Yuichi Ootsuka and Yoshiro Tsuji and Tetsuya Yokoo and Katsutoshi Hayashi and Kunio Tomimasu and Toshihiko Kido and Yutaka Uehara and Junko Mori and Goichi Mori and Tetsuya Uchida and Yuichi Ootsuka and Takashi Motohiro and Shoichi Handa and Shuji Yamada and Oki, {Shin ichiro} and Yoichiro Yoshinaga and Masafumi Aramaki and Keiko Oda and Yasutaka Sakata and Hirohisa Kato and Fumio Yamashita and Shoichi Imai and Kazushige Suzuki and Sayuri Okabayashi and Shinya Kaneko and Kotaro Ichikawa and Hiroko Soda and Toko Shimizu and Yoichi Nagata and Marie Kiba and Shinsaku Ishibashi and Koichi Takahashi and Amiko Sugiyama and Takumi Miyake and Hisaaki Araki and Mitsuo Kakisako and Yasuki Maeno and Tsuyoshi Shimohida and Tomoya Takagishi and Yoshinori Matsukuma and Tomoshige Hirata and Nobuo Tanaka and Kiyotaka Nagayama and Chikai Yasuoka and Masao Hayashi and Masano Amamoto and Naoki Tsumura and Eiichiro Ono and Shintaro Kamizono and Eisuke Nakashima and Shinichiro Nagamitsu and Takayo Nomasa and Yusaku Matsuo and Emi Higuchi and Kensuke Nagai and Keiko Sueyoshi and Nobuo Hashimoto and Ken Yuge and Kaoru Kubota and Akira Kawakami and Yoriko Watanabe and Takuji Fujisawa and Toru Nishiyama and Rikako Iwanaga and Kosuke Ushijima and Ryoichi Yamakawa and Jyunichi Yamamura and Kaoru Tominaga and Syunichi Dai and Hiroshi Ando and Naoki Kuda and Tamotsu Fujimoto and Hirotaka Motoyama and Takayuki Maruoka and Yukiji Date and Toru Sugimura and Sunao Nishiyori and Yuki Asakino and Katsuhiko Yamada and Seigo Kotematsu and Hiroshi Hayakawa and Hirokazu Sasaki and Koichi Kimura and Takashi Yamada",

year = "1995",

month = jul,

doi = "10.11553/antibiotics1968b.48.921",

language = "English",

volume = "48",

pages = "921--941",

journal = "The Journal of antibiotics. Ser. B",

issn = "0368-2781",

publisher = "Japan Antibiotics Research Association",

number = "7",

}

TY - JOUR

T1 - Pharmacokinetic and clinical studies of s-1108 in the pediatric field

AU - Fujii, Ryochi

AU - Abe, Toshiaki

AU - Tajima, Takeshi

AU - Terashima, Itaru

AU - Meguro, Hidenori

AU - Mori, Atsuo

AU - Sato, Hajime

AU - Niino, Kenji

AU - Sato, Hajime

AU - Niino, Kenji

AU - Sunakawa, Keisuke

AU - Yokota, Takao

AU - Akita, Hironobu

AU - Iwata, Satoshi

AU - Satoh, Yoshitake

AU - Sunakawa, Keisuke

AU - Yokota, Takao

AU - Akita, Hironobu

AU - Iwata, Satoshi

AU - Satoh, Yoshitake

AU - Sunakawa, Keisuke

AU - Yokota, Takao

AU - Akita, Hironobu

AU - Iwata, Satoshi

AU - Satoh, Yoshitake

AU - Sunakawa, Keisuke

AU - Yokota, Takao

AU - Akita, Hironobu

AU - Iwata, Satoshi

AU - Satoh, Yoshitake

AU - Toyonaga, Yoshikiyo

AU - Ishihara, Toshihide

AU - Sano, Tomoaki

AU - Nakamura, Hironori

AU - Toyonaga, Yoshikiyo

AU - Ishihara, Toshihide

AU - Sano, Tomoaki

AU - Nakamura, Hironori

AU - Iwai, Naoichi

AU - Nakamura, Haruhi

AU - Miyazu, Mitsunobu

AU - Watanabe, Yumi

AU - Kuno, Kuniyoshi

AU - Kamiya, Hitoshi

AU - Kitamura, Kenji

AU - Ihara, Toshiaki

AU - Sakurai, Minoru

AU - Azuma, Eiichi

AU - Itoh, Masahiro

AU - Kamiya, Hitoshi

AU - Kitamura, Kenji

AU - Ihara, Toshiaki

AU - Sakurai, Minoru

AU - Azuma, Eiichi

AU - Itoh, Masahiro

AU - Mikawa, Haruki

AU - Kubota, Masaru

AU - Momoi, Tohru

AU - Hosoi, Susumu

AU - Nakato, Hidekazu

AU - Mikawa, Haruki

AU - Kubota, Masaru

AU - Momoi, Tohru

AU - Hosoi, Susumu

AU - Nakato, Hidekazu

AU - Mikawa, Haruki

AU - Kubota, Masaru

AU - Momoi, Tohru

AU - Hosoi, Susumu

AU - Nakato, Hidekazu

AU - Nishimura, Tadafumi

AU - Sugita, Kumiko

AU - Aoki, Shigeyuki

AU - Takagi, Michio

AU - Nishimura, Tadafumi

AU - Sugita, Kumiko

AU - Aoki, Shigeyuki

AU - Takagi, Michio

AU - Nishimura, Tadafumi

AU - Sugita, Kumiko

AU - Aoki, Shigeyuki

AU - Takagi, Michio

AU - Kobayashi, Yohnosuke

AU - Higashi, Hirohiko

AU - Kino, Minoru

AU - Kobayashi, Yutaka

AU - Haruta, Tsunekazu

AU - Kuroki, Shigekazu

AU - Okura, Kan etsu

AU - Okada, Takashige

AU - Furukawa, Seikyo

AU - Kuroda, Yasuhiro

AU - Takeda, Eiji

AU - Ito, Michinori

AU - Matsuda, Hiroshi

AU - Ishikawa, Junichi

AU - Kida, Kaichi

AU - Murase, Mitsuharu

AU - Matsuda, Hiroshi

AU - Ishikawa, Junichi

AU - Kida, Kaichi

AU - Murase, Mitsuharu

AU - Kurashige, Takanobu

AU - Morita, Hideo

AU - Morisawa, Yutaka

AU - Hamada, Fumihiko

AU - Tsuji, Yoshiro

AU - Yokoo, Tetsuya

AU - Hayashi, Katsutoshi

AU - Tomimasu, Kunio

AU - Kido, Toshihiko

AU - Uehara, Yutaka

AU - Mori, Junko

AU - Mori, Goichi

AU - Uchida, Tetsuya

AU - Ootsuka, Yuichi

AU - Tsuji, Yoshiro

AU - Yokoo, Tetsuya

AU - Hayashi, Katsutoshi

AU - Tomimasu, Kunio

AU - Kido, Toshihiko

AU - Uehara, Yutaka

AU - Mori, Junko

AU - Mori, Goichi

AU - Uchida, Tetsuya

AU - Ootsuka, Yuichi

AU - Tsuji, Yoshiro

AU - Yokoo, Tetsuya

AU - Hayashi, Katsutoshi

AU - Tomimasu, Kunio

AU - Kido, Toshihiko

AU - Uehara, Yutaka

AU - Mori, Junko

AU - Mori, Goichi

AU - Uchida, Tetsuya

AU - Ootsuka, Yuichi

AU - Tsuji, Yoshiro

AU - Yokoo, Tetsuya

AU - Hayashi, Katsutoshi

AU - Tomimasu, Kunio

AU - Kido, Toshihiko

AU - Uehara, Yutaka

AU - Mori, Junko

AU - Mori, Goichi

AU - Uchida, Tetsuya

AU - Ootsuka, Yuichi

AU - Motohiro, Takashi

AU - Handa, Shoichi

AU - Yamada, Shuji

AU - Oki, Shin ichiro

AU - Yoshinaga, Yoichiro

AU - Aramaki, Masafumi

AU - Oda, Keiko

AU - Sakata, Yasutaka

AU - Kato, Hirohisa

AU - Yamashita, Fumio

AU - Imai, Shoichi

AU - Suzuki, Kazushige

AU - Okabayashi, Sayuri

AU - Kaneko, Shinya

AU - Ichikawa, Kotaro

AU - Soda, Hiroko

AU - Shimizu, Toko

AU - Nagata, Yoichi

AU - Kiba, Marie

AU - Ishibashi, Shinsaku

AU - Takahashi, Koichi

AU - Sugiyama, Amiko

AU - Miyake, Takumi

AU - Araki, Hisaaki

AU - Kakisako, Mitsuo

AU - Maeno, Yasuki

AU - Shimohida, Tsuyoshi

AU - Takagishi, Tomoya

AU - Matsukuma, Yoshinori

AU - Hirata, Tomoshige

AU - Tanaka, Nobuo

AU - Nagayama, Kiyotaka

AU - Yasuoka, Chikai

AU - Hayashi, Masao

AU - Amamoto, Masano

AU - Tsumura, Naoki

AU - Ono, Eiichiro

AU - Kamizono, Shintaro

AU - Nakashima, Eisuke

AU - Nagamitsu, Shinichiro

AU - Nomasa, Takayo

AU - Matsuo, Yusaku

AU - Higuchi, Emi

AU - Nagai, Kensuke

AU - Sueyoshi, Keiko

AU - Hashimoto, Nobuo

AU - Yuge, Ken

AU - Kubota, Kaoru

AU - Kawakami, Akira

AU - Watanabe, Yoriko

AU - Fujisawa, Takuji

AU - Nishiyama, Toru

AU - Iwanaga, Rikako

AU - Ushijima, Kosuke

AU - Yamakawa, Ryoichi

AU - Yamamura, Jyunichi

AU - Tominaga, Kaoru

AU - Dai, Syunichi

AU - Ando, Hiroshi

AU - Kuda, Naoki

AU - Fujimoto, Tamotsu

AU - Motoyama, Hirotaka

AU - Maruoka, Takayuki

AU - Date, Yukiji

AU - Sugimura, Toru

AU - Nishiyori, Sunao

AU - Asakino, Yuki

AU - Yamada, Katsuhiko

AU - Kotematsu, Seigo

AU - Hayakawa, Hiroshi

AU - Sasaki, Hirokazu

AU - Kimura, Koichi

AU - Yamada, Takashi

PY - 1995/7

Y1 - 1995/7

N2 - S-1108 in granules, a new oral cephem antibiotic, was pharmacokinetically and clinically evaluated in the pediatric field and the following results were obtained. 1. Pharmacokinetics S-1108 was administered at single doses of 2, 3, 4, 6 mg/kg orally and the following results were obtained on Cmax, T 1/2 and AUC, respectively: Cmax: 0.79, 1.03, 1.39, 1.06 µg/ml, T 1/2: 1.28 ±0.40, 1.27±0.65, 1.10±0.29, 1.83 hrs., AUC: 2.65±0.63, 3.99±2.77, 5.25±1.83, 5.15 µg·hr/ml. These values indicated a dose-dependent pharmacokinetic behavior. Urinary recovery rates were 12.5-30.0% in the first 8(6) hours after administration. 2. Clinical results The clinical efficacy of S-1108 was evaluated in 456 patients with various infections. S-1108 was administered at a dose of 2–4mg/kg three time a day to most patients. The overall clinical efficacy rate was 95.0%. In 294 cases with identified causative pathogen, the clinical efficacy rate was 96.9%, and the bacteriological eradication rate was 89.0%. Side effects occurred in 18 (3.23%) of 558 patients subjected to safety analyses. The main side effect was diarrhea but those side effects were mild and reversible. Abnormal laboratory test results were observed in 25 cases, (eosinophilia and elevated GOT and GPT). These abnormalities were not dose-dependent and also seen with other cephems to a similar extent. No particular and serious problems were associated with administration of this drug. Based on the above results, S-1108 is considered to be very useful at a standard dose of 2–4 mg/kg t.i.d. against most infections encountered in the pediatric field out-patient clinic.

AB - S-1108 in granules, a new oral cephem antibiotic, was pharmacokinetically and clinically evaluated in the pediatric field and the following results were obtained. 1. Pharmacokinetics S-1108 was administered at single doses of 2, 3, 4, 6 mg/kg orally and the following results were obtained on Cmax, T 1/2 and AUC, respectively: Cmax: 0.79, 1.03, 1.39, 1.06 µg/ml, T 1/2: 1.28 ±0.40, 1.27±0.65, 1.10±0.29, 1.83 hrs., AUC: 2.65±0.63, 3.99±2.77, 5.25±1.83, 5.15 µg·hr/ml. These values indicated a dose-dependent pharmacokinetic behavior. Urinary recovery rates were 12.5-30.0% in the first 8(6) hours after administration. 2. Clinical results The clinical efficacy of S-1108 was evaluated in 456 patients with various infections. S-1108 was administered at a dose of 2–4mg/kg three time a day to most patients. The overall clinical efficacy rate was 95.0%. In 294 cases with identified causative pathogen, the clinical efficacy rate was 96.9%, and the bacteriological eradication rate was 89.0%. Side effects occurred in 18 (3.23%) of 558 patients subjected to safety analyses. The main side effect was diarrhea but those side effects were mild and reversible. Abnormal laboratory test results were observed in 25 cases, (eosinophilia and elevated GOT and GPT). These abnormalities were not dose-dependent and also seen with other cephems to a similar extent. No particular and serious problems were associated with administration of this drug. Based on the above results, S-1108 is considered to be very useful at a standard dose of 2–4 mg/kg t.i.d. against most infections encountered in the pediatric field out-patient clinic.

UR - http://www.scopus.com/inward/record.url?scp=0029027061&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0029027061&partnerID=8YFLogxK

U2 - 10.11553/antibiotics1968b.48.921

DO - 10.11553/antibiotics1968b.48.921

M3 - Article

C2 - 7563586

AN - SCOPUS:0029027061

SN - 0368-2781

VL - 48

SP - 921

EP - 941

JO - The Journal of antibiotics. Ser. B

JF - The Journal of antibiotics. Ser. B

IS - 7

ER -

Pharmacokinetic and clinical studies of s-1108 in the pediatric field

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