Pharmacokinetic and clinical studies on flomoxef in neonates and premature infants

H. Akita, Y. Sato, S. Iwata, K. Sunakawa, T. Yokota

Research output: Contribution to journalArticle

Abstract

Studies were made on pharmacokinetics, clinical effects and influence on intestinal bacterial flora in neonates upon administration of flomoxef (FMOX), and the results obtained are summarized as follows: 1. Serum concentrations of FMOX after intravenous administration of 20 mg/kg/dose were 48.5 μg/ml in 30 minutes, 33.0 μg/ml in 1 hour and 7.3 μg/ml in 6 hours. The T 1/2 was 2.7 hours. FMOX at a dose of 40 mg/kg was given to only one new born baby on the 1st day after birth, and serum concentrations were 73.6 μg/ml in 30 minutes, 55.9 μg/ml in 1 hour and 16.9 μg/ml in 6 hours. The T 1/2 was 4.60 hours. 2. FMOX was administered to 21 neonates between 0 and 32 days of age. Clinical effects were evaluable in 8 of 21 cases. The results were excellent in 2 cases, good in 5 cases and poor in 1 case. Of the 21 cases, diarrhea in 1 case, elevation of eosinophile in 2 cases (9.5%), elevation of platelet count in 3 cases (14.3%), and elevation of GOT in 2 cases (9.5%) were recognized during treatment. 3. FMOX was detected in feces at levels of 0.84~44.4 μg/g. Except for a slight decrease in numbers of anaerobes, little fluctuations of intestinal flora were observed during treatment.

Original languageEnglish
Pages (from-to)1240-1249
Number of pages10
JournalJapanese Journal of Antibiotics
Volume44
Issue number11
Publication statusPublished - 1991
Externally publishedYes

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Premature Infants
Pharmacokinetics
Newborn Infant
Serum
Platelet Count
Eosinophils
Feces
Intravenous Administration
Diarrhea
flomoxef
Clinical Studies
Parturition
Therapeutics
Gastrointestinal Microbiome

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology

Cite this

Akita, H., Sato, Y., Iwata, S., Sunakawa, K., & Yokota, T. (1991). Pharmacokinetic and clinical studies on flomoxef in neonates and premature infants. Japanese Journal of Antibiotics, 44(11), 1240-1249.

Pharmacokinetic and clinical studies on flomoxef in neonates and premature infants. / Akita, H.; Sato, Y.; Iwata, S.; Sunakawa, K.; Yokota, T.

In: Japanese Journal of Antibiotics, Vol. 44, No. 11, 1991, p. 1240-1249.

Research output: Contribution to journalArticle

Akita, H, Sato, Y, Iwata, S, Sunakawa, K & Yokota, T 1991, 'Pharmacokinetic and clinical studies on flomoxef in neonates and premature infants', Japanese Journal of Antibiotics, vol. 44, no. 11, pp. 1240-1249.
Akita, H. ; Sato, Y. ; Iwata, S. ; Sunakawa, K. ; Yokota, T. / Pharmacokinetic and clinical studies on flomoxef in neonates and premature infants. In: Japanese Journal of Antibiotics. 1991 ; Vol. 44, No. 11. pp. 1240-1249.
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