Pharmacokinetic study of penetration of meropenem into pleural effusion in patients with pleurisy

Junko Makino, Yuji Yoshiyama, Motoko Kanke, Toshiaki Shibasaki, Emi Nakashima, Masahiro Kamata, Sadanobu Ozawa, Hiromichi Maruyama, Keisou Masuhara, Teruaki Kobayashi

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Complication by secondary infection is observed in not only bacterial pleurisy but also other pleurisy, and the appropriate administration of antibacterial agents is necessary. It is very important to secure a smooth penetration of systemically administered antibacterial agents to pleural effusion in infection therapy. In this study, we investigated the pharmacokinetics of a carbapenem antibiotic, meropenem (MEPM), in blood and pleural effusion in patients with an accumulation of pleural effusion caused by pleurisy, who underwent placement of an indwelling thoracic drain and received intravenous drip administration of MEPM for pneumonia or other respiratory tract infection. The blood pharmacokinetic parameters of MEPM after an intravenous drip administration of 0.5 g MEPM in six patients were: area under the blood concentration-time curve (AUC), 37.9±6.2 (hr.mg/L); volume of distribution (Vd), 27.3±4.4 (L); total clearance (CLtotal), 13.4±1.8 (L/hr); elimination half life (t1/2), 0.50 ± 0.08 (hr-1); and elimination rate constant (kel), 1.42±0.22 (hr). The pharmacokinetic parameters in pleural effusion were: AUC, 35.7±7.1 (hr mg/L); mean retention time (MRT), 5.00±3.25 (hr); variance of retention time (VRT), 29.9±44.6 (hr2); kel, 0.34±0.27 (hr-1); and t1/2, 3.14±2.36 (hr). The penetration rate1 calculated from the ratio of pleural concentration to blood concentration in each patient was 46.5±26.1%, showing good penetration comparable or superior to those of other antibacterial agents previously reported. From these results, it was suggested that MEPM was rapidly penetrated to the pleural effusion and was retained for a more prolonged time in the pleural effusion than in the blood of patients with accumulated pleural effusion, and it suggested the usefulness of MEPM in antibacterial therapy for patients with pleurisy causing accumulation of pleural effusion.

Original languageEnglish
Pages (from-to)77-88
Number of pages12
JournalJapanese Journal of Antibiotics
Volume55
Issue number1
Publication statusPublished - 2002

Fingerprint

meropenem
Pleurisy
Pleural Effusion
Pharmacokinetics
Anti-Bacterial Agents
Intravenous Infusions
Intravenous Administration
Area Under Curve
Carbapenems
Coinfection
Respiratory Tract Infections

ASJC Scopus subject areas

  • Pharmacology
  • Molecular Medicine

Cite this

Makino, J., Yoshiyama, Y., Kanke, M., Shibasaki, T., Nakashima, E., Kamata, M., ... Kobayashi, T. (2002). Pharmacokinetic study of penetration of meropenem into pleural effusion in patients with pleurisy. Japanese Journal of Antibiotics, 55(1), 77-88.

Pharmacokinetic study of penetration of meropenem into pleural effusion in patients with pleurisy. / Makino, Junko; Yoshiyama, Yuji; Kanke, Motoko; Shibasaki, Toshiaki; Nakashima, Emi; Kamata, Masahiro; Ozawa, Sadanobu; Maruyama, Hiromichi; Masuhara, Keisou; Kobayashi, Teruaki.

In: Japanese Journal of Antibiotics, Vol. 55, No. 1, 2002, p. 77-88.

Research output: Contribution to journalArticle

Makino, J, Yoshiyama, Y, Kanke, M, Shibasaki, T, Nakashima, E, Kamata, M, Ozawa, S, Maruyama, H, Masuhara, K & Kobayashi, T 2002, 'Pharmacokinetic study of penetration of meropenem into pleural effusion in patients with pleurisy', Japanese Journal of Antibiotics, vol. 55, no. 1, pp. 77-88.
Makino J, Yoshiyama Y, Kanke M, Shibasaki T, Nakashima E, Kamata M et al. Pharmacokinetic study of penetration of meropenem into pleural effusion in patients with pleurisy. Japanese Journal of Antibiotics. 2002;55(1):77-88.
Makino, Junko ; Yoshiyama, Yuji ; Kanke, Motoko ; Shibasaki, Toshiaki ; Nakashima, Emi ; Kamata, Masahiro ; Ozawa, Sadanobu ; Maruyama, Hiromichi ; Masuhara, Keisou ; Kobayashi, Teruaki. / Pharmacokinetic study of penetration of meropenem into pleural effusion in patients with pleurisy. In: Japanese Journal of Antibiotics. 2002 ; Vol. 55, No. 1. pp. 77-88.
@article{668bdb9eafbd44e0a7dd15afb6b6a0b1,
title = "Pharmacokinetic study of penetration of meropenem into pleural effusion in patients with pleurisy",
abstract = "Complication by secondary infection is observed in not only bacterial pleurisy but also other pleurisy, and the appropriate administration of antibacterial agents is necessary. It is very important to secure a smooth penetration of systemically administered antibacterial agents to pleural effusion in infection therapy. In this study, we investigated the pharmacokinetics of a carbapenem antibiotic, meropenem (MEPM), in blood and pleural effusion in patients with an accumulation of pleural effusion caused by pleurisy, who underwent placement of an indwelling thoracic drain and received intravenous drip administration of MEPM for pneumonia or other respiratory tract infection. The blood pharmacokinetic parameters of MEPM after an intravenous drip administration of 0.5 g MEPM in six patients were: area under the blood concentration-time curve (AUC∞), 37.9±6.2 (hr.mg/L); volume of distribution (Vd), 27.3±4.4 (L); total clearance (CLtotal), 13.4±1.8 (L/hr); elimination half life (t1/2), 0.50 ± 0.08 (hr-1); and elimination rate constant (kel), 1.42±0.22 (hr). The pharmacokinetic parameters in pleural effusion were: AUC∞, 35.7±7.1 (hr mg/L); mean retention time (MRT), 5.00±3.25 (hr); variance of retention time (VRT), 29.9±44.6 (hr2); kel, 0.34±0.27 (hr-1); and t1/2, 3.14±2.36 (hr). The penetration rate1 calculated from the ratio of pleural concentration to blood concentration in each patient was 46.5±26.1{\%}, showing good penetration comparable or superior to those of other antibacterial agents previously reported. From these results, it was suggested that MEPM was rapidly penetrated to the pleural effusion and was retained for a more prolonged time in the pleural effusion than in the blood of patients with accumulated pleural effusion, and it suggested the usefulness of MEPM in antibacterial therapy for patients with pleurisy causing accumulation of pleural effusion.",
author = "Junko Makino and Yuji Yoshiyama and Motoko Kanke and Toshiaki Shibasaki and Emi Nakashima and Masahiro Kamata and Sadanobu Ozawa and Hiromichi Maruyama and Keisou Masuhara and Teruaki Kobayashi",
year = "2002",
language = "English",
volume = "55",
pages = "77--88",
journal = "The Journal of antibiotics. Ser. B",
issn = "0368-2781",
publisher = "Japan Antibiotics Research Association",
number = "1",

}

TY - JOUR

T1 - Pharmacokinetic study of penetration of meropenem into pleural effusion in patients with pleurisy

AU - Makino, Junko

AU - Yoshiyama, Yuji

AU - Kanke, Motoko

AU - Shibasaki, Toshiaki

AU - Nakashima, Emi

AU - Kamata, Masahiro

AU - Ozawa, Sadanobu

AU - Maruyama, Hiromichi

AU - Masuhara, Keisou

AU - Kobayashi, Teruaki

PY - 2002

Y1 - 2002

N2 - Complication by secondary infection is observed in not only bacterial pleurisy but also other pleurisy, and the appropriate administration of antibacterial agents is necessary. It is very important to secure a smooth penetration of systemically administered antibacterial agents to pleural effusion in infection therapy. In this study, we investigated the pharmacokinetics of a carbapenem antibiotic, meropenem (MEPM), in blood and pleural effusion in patients with an accumulation of pleural effusion caused by pleurisy, who underwent placement of an indwelling thoracic drain and received intravenous drip administration of MEPM for pneumonia or other respiratory tract infection. The blood pharmacokinetic parameters of MEPM after an intravenous drip administration of 0.5 g MEPM in six patients were: area under the blood concentration-time curve (AUC∞), 37.9±6.2 (hr.mg/L); volume of distribution (Vd), 27.3±4.4 (L); total clearance (CLtotal), 13.4±1.8 (L/hr); elimination half life (t1/2), 0.50 ± 0.08 (hr-1); and elimination rate constant (kel), 1.42±0.22 (hr). The pharmacokinetic parameters in pleural effusion were: AUC∞, 35.7±7.1 (hr mg/L); mean retention time (MRT), 5.00±3.25 (hr); variance of retention time (VRT), 29.9±44.6 (hr2); kel, 0.34±0.27 (hr-1); and t1/2, 3.14±2.36 (hr). The penetration rate1 calculated from the ratio of pleural concentration to blood concentration in each patient was 46.5±26.1%, showing good penetration comparable or superior to those of other antibacterial agents previously reported. From these results, it was suggested that MEPM was rapidly penetrated to the pleural effusion and was retained for a more prolonged time in the pleural effusion than in the blood of patients with accumulated pleural effusion, and it suggested the usefulness of MEPM in antibacterial therapy for patients with pleurisy causing accumulation of pleural effusion.

AB - Complication by secondary infection is observed in not only bacterial pleurisy but also other pleurisy, and the appropriate administration of antibacterial agents is necessary. It is very important to secure a smooth penetration of systemically administered antibacterial agents to pleural effusion in infection therapy. In this study, we investigated the pharmacokinetics of a carbapenem antibiotic, meropenem (MEPM), in blood and pleural effusion in patients with an accumulation of pleural effusion caused by pleurisy, who underwent placement of an indwelling thoracic drain and received intravenous drip administration of MEPM for pneumonia or other respiratory tract infection. The blood pharmacokinetic parameters of MEPM after an intravenous drip administration of 0.5 g MEPM in six patients were: area under the blood concentration-time curve (AUC∞), 37.9±6.2 (hr.mg/L); volume of distribution (Vd), 27.3±4.4 (L); total clearance (CLtotal), 13.4±1.8 (L/hr); elimination half life (t1/2), 0.50 ± 0.08 (hr-1); and elimination rate constant (kel), 1.42±0.22 (hr). The pharmacokinetic parameters in pleural effusion were: AUC∞, 35.7±7.1 (hr mg/L); mean retention time (MRT), 5.00±3.25 (hr); variance of retention time (VRT), 29.9±44.6 (hr2); kel, 0.34±0.27 (hr-1); and t1/2, 3.14±2.36 (hr). The penetration rate1 calculated from the ratio of pleural concentration to blood concentration in each patient was 46.5±26.1%, showing good penetration comparable or superior to those of other antibacterial agents previously reported. From these results, it was suggested that MEPM was rapidly penetrated to the pleural effusion and was retained for a more prolonged time in the pleural effusion than in the blood of patients with accumulated pleural effusion, and it suggested the usefulness of MEPM in antibacterial therapy for patients with pleurisy causing accumulation of pleural effusion.

UR - http://www.scopus.com/inward/record.url?scp=0036219944&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036219944&partnerID=8YFLogxK

M3 - Article

VL - 55

SP - 77

EP - 88

JO - The Journal of antibiotics. Ser. B

JF - The Journal of antibiotics. Ser. B

SN - 0368-2781

IS - 1

ER -