Pharmacokinetics and clinical studies on cefsulodin in neonates

Satoshi Iwata, Yoshitake Sato, Masahiro Tojo, Yutaka Kusumoto, Hiroyuki Shiro, Hironobu Akita, Seiichiro Nanri, Tadao Oikawas, Mitsuru Osano, Shoichi Kusano, Keisuke Sunakawa, Yasuo Ichihashi

Research output: Contribution to journalArticle

Abstract

Pharmacokinetics and clinical studies on cefsulodin (CFS) were conducted in neonates. 1. MICs of CFS, sulbenicillin and gentamicin (GM) were determined using 7 strains of Pseudomonas aeruginosa clinically isolated from neonates and maintained as stock cultures. CFS was found to be nearly as active as GM. 2. When CFS 20 mg/kg was administered to a 12-day-old neonate by intravenous bolus injection, serum concentrations were 8.7 µ/g/ml before administration and 51.7 µ/g/ml at 30 minutes, 44.4 µ/g/ml at 1 hour, 38.6 µ/g/ml at 2 hours and 11.1 µ/g/ml at 6 hours after administration. The half-life was 2.5 hours. 3. CFS was administered alone or combination with other drugs to 3 neonates. The drug was clinically effective in 2 cases and slightly effective in another. Bacteriologically, one case was rated as decreased, another as replaced, and the remaining one as unchanged. 4. Neither side effects nor abnormal laboratory values attributable to CFS were found.

Original languageEnglish
Pages (from-to)2714-2719
Number of pages6
Journalthe japanese journal of antibiotics
Volume42
Issue number12
DOIs
Publication statusPublished - 1989 Jan 1

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

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    Iwata, S., Sato, Y., Tojo, M., Kusumoto, Y., Shiro, H., Akita, H., Nanri, S., Oikawas, T., Osano, M., Kusano, S., Sunakawa, K., & Ichihashi, Y. (1989). Pharmacokinetics and clinical studies on cefsulodin in neonates. the japanese journal of antibiotics, 42(12), 2714-2719. https://doi.org/10.11553/antibiotics1968b.42.2714