Pharmacokinetics, efficacy and safety of bosutinib in a pediatric patient with chronic myeloid leukemia

Akiko Inoue, Chiyo Imamura, Hiroyuki Shimada, Daisuke Katayama, Keisuke Urabe, Ryo Suzuki, Kimitaka Takitani, Akira Ashida

Research output: Contribution to journalArticlepeer-review

Abstract

Bosutinib is a second-generation tyrosine kinase inhibitor indicated for treatment of chronic myeloid leukemia (CML) in adult patients. The safety and efficacy of bosutinib in patients younger than 18 years of age have not been established. We here report the case of a 4-year-old male with CML who was treated with bosutinib during coordination of human leukocyte antigen–matched unrelated bone-marrow transplantation because of insufficient responses to imatinib and dasatinib. The patient achieved a complete cytogenetic response immediately after starting bosutinib at 180 mg/day (290 mg/m2/day). Because toxicity was tolerable, the dose was increased to 200 mg/day (330 mg/m2/day). A complete cytogenetic response was maintained, but a major molecular response was not achieved 6 months after initiation of treatment with bosutinib. At steady state, maximum plasma concentration, minimum plasma concentration, and area under the plasma concentration-time curve were 89.2 ng/mL, 16.7 ng/mL, and 1017.4 ng·hr/mL, respectively, at 290 mg/m2/day; and 141.1 ng/mL, 18.9 ng/mL, and 1278.5 ng·hr/mL, respectively, at 330 mg/m2/day. To the best of our knowledge, this is the first case report to show the pharmacokinetics of bosutinib with efficacy and safety in a pediatric patient with CML. This rare case in a very young child with CML can also be valuable reference for clinical practice.

Original languageEnglish
Pages (from-to)742-745
Number of pages4
JournalJournal of Pediatric Pharmacology and Therapeutics
Volume25
Issue number8
DOIs
Publication statusPublished - 2020

Keywords

  • Bosutinib
  • Chronic myeloid leukemia
  • Exposure-response relationship
  • Pediatric patient
  • Pharmacokinetics
  • Tyrosine kinase inhibitor

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pharmacology (medical)

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