Pharmacokinetics of arbekacin in bronchial epithelial lining fluid of healthy volunteers

Yohei Funatsu, Naoki Hasegawa, Hiroshi Fujiwara, Ho Namkoong, Takahiro Asami, Sadatomo Tasaka, Yoshifumi Kimizuka, Hirofumi Kamata, Makoto Ishii, Osamu Iketani, Haruhiko Ogata, Satoshi Iwata, Tomoko Betsuyaku

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Arbekacin is a unique aminoglycoside antibiotic with anti-methicillin-resistant Staphylococcus aureus activity. The efficacy of aminoglycosides is related to their serum maximum concentration. Local concentration of antibiotics in pulmonary epithelial lining fluid, rather than its serum concentration, can help determine its clinical efficacy more precisely for treatment of respiratory infectious disease. The objective of this study was to sequentially measure arbekacin concentration in epithelial lining fluid after infusion of a single clinically available dose.

Method: After the initial blood sampling, arbekacin was intravenously infused into 6 healthy volunteers over 1 h. Epithelial lining fluid and serum samples were collected by bronchoscopic microsampling 1, 1.5, 2, 2.5, 3, 4, 5, and 6 h after the start of 200 mg arbekacin infusion.

Results: Each probe sampled 10.1 ± 5.2 μl bronchial epithelial lining fluid. The sample dilution factor was 266.7 ± 157.1. Drug concentration was successfully measured in all but 2 of the epithelial lining fluid samples. The maximum concentration of arbekacin in epithelial lining fluid and serum was 10.4 ± 1.9 μg/ ml and 26.0 ± 12.2 μg/ml, respectively. The ratio of the maximum drug concentration in the epithelial lining fluid to that in the serum was 0.47 ± 0.19.

Conclusions: The maximum concentration of epithelial lining fluid reached levels that would effectively treat most clinical strains of methicillin-resistant S. aureus.

Original languageEnglish
Pages (from-to)607-611
Number of pages5
JournalJournal of Infection and Chemotherapy
Volume20
Issue number10
DOIs
Publication statusPublished - 2014 Oct 1

Keywords

  • Aminoglycoside
  • Arbekacin
  • Bronchoscopic microsampling
  • Epithelial lining fluid
  • Methicillin-resistant Staphylococcus aureus
  • Pharmacokinetic/pharmacodynamic

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

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  • Cite this

    Funatsu, Y., Hasegawa, N., Fujiwara, H., Namkoong, H., Asami, T., Tasaka, S., Kimizuka, Y., Kamata, H., Ishii, M., Iketani, O., Ogata, H., Iwata, S., & Betsuyaku, T. (2014). Pharmacokinetics of arbekacin in bronchial epithelial lining fluid of healthy volunteers. Journal of Infection and Chemotherapy, 20(10), 607-611. https://doi.org/10.1016/j.jiac.2014.05.007