Pharmacokinetics Study On Gentamicin Intravenous Drip Infusion In Children

Keisuke Sunakawa, Takeo Matsuo, Yasuo Ichihashi, Hironobu Akita, Zenzaburo Yamada, Keiji Jozaki, Hiroko Suzuki, Satoshi Iwata, Yukio Iwasaki, Yoshitake Sato, Masahiro Tojoh, Ryo Wakabayashi, Shinya Hayano, Mitsuru Osano

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Pharmacokinetics of gentamicin in children after intravenous infusion over 60 minutes were compared with that after intramuscular injection. 1. Mean measured peak serum levels after intravenous infusion of 2.5 mg/kg and intramuscular injection of 2.0 mg/kg were 6.1 /*g/ml at termination of infusion and 6.5µg/ml at 30 or 60 minutes after injection, respectively. Older children showed higher serum levels. 2. There was no difference in serum half-life between both modes of administration. 3. The AUC after intravenous infusion was slightly larger than that after intramuscular injection. 4. It was suggested that the efficacy and safety of the treatment by intravenous infusion in children are comparable to that by the intramuscular injection, and optimum single dose is 1.5 ~ 2.5 mg/kg.

Original languageEnglish
Pages (from-to)47-54
Number of pages8
Journalthe japanese journal of antibiotics
Volume36
Issue number1
DOIs
Publication statusPublished - 1983

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

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    Sunakawa, K., Matsuo, T., Ichihashi, Y., Akita, H., Yamada, Z., Jozaki, K., Suzuki, H., Iwata, S., Iwasaki, Y., Sato, Y., Tojoh, M., Wakabayashi, R., Hayano, S., & Osano, M. (1983). Pharmacokinetics Study On Gentamicin Intravenous Drip Infusion In Children. the japanese journal of antibiotics, 36(1), 47-54. https://doi.org/10.11553/antibiotics1968b.36.47