Pharmacology of acute lung injury

Sadatomo Tasaka, Naoki Hasegawa, Akitoshi Ishizaka

Research output: Contribution to journalReview article

46 Citations (Scopus)

Abstract

The acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is a clinical syndrome that affects both medical and surgical patients. To date, despite improved understanding of the pathogenesis of ALI/ARDS, pharmacological modalities have been unsuccessful in decreasing mortality. However, several pharmacological agents for ARDS are in development and have shown great promise. In addition to the anti-inflammatory category including late corticosteroids, inhaled nitric oxide, alveolar surfactant, and vasodilators are being evaluated. Replacements of anticoagulation mediators have also suggested beneficial effects on the patient outcome. This article provides an overview of pharmacological treatments of ALI/ARDS.

Original languageEnglish
Pages (from-to)83-95
Number of pages13
JournalPulmonary Pharmacology and Therapeutics
Volume15
Issue number2
DOIs
Publication statusPublished - 2002 Jan 1

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Keywords

  • ALI/ARDS
  • Pharmacological treatment
  • Sepsis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Biochemistry, medical
  • Pharmacology (medical)

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