Phase diagrams of confined solutions of dimyristoylphosphatidylcholine (DMPC) lipid and cholesterol in nanotubes

Noriyoshi Arai, Kenji Yasuoka, Xiao Cheng Zeng

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10 Citations (Scopus)


We have studied equilibrium morphologies of dimyristoylphosphatidylcholine lipid solution and cholesterol solution confined to nanotubes using dissipative particle dynamics (DPD) simulations. Phase diagrams regarding monomer concentration c versus radius of nanotube r for both solutions are attained. Three types of the inner surface of nanotubes, namely hydrophobic, hydrophilic, and hydroneutral are considered in the DPD simulations. A number of phases and molecular assemblies for the confined solutions are revealed, among others, such as the spiral wetting and bilayer helix. Several phases and assemblies have not been reported in the literature, and some are non-existence in bulk solutions. The ability to control the morphologies and self-assemblies within nanoscale confinement can be exploited for patterning interior surface of nanochannels for application in nanofluidics and nanomedical devices.

Original languageEnglish
Pages (from-to)995-1010
Number of pages16
JournalMicrofluidics and Nanofluidics
Issue number6
Publication statusPublished - 2013 Jun 1



  • Dissipative particle dynamics
  • Equilibrium morphology
  • Nanoscale confinement
  • Phase diagram
  • Self-assembly

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Materials Chemistry

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