Phasic reward responses in the monkey striatum as detected by voltammetry with diamond microelectrodes

Kenji Yoshimi, Yuuki Naya, Naoko Mitani, Taisuke Kato, Masato Inoue, Shihoko Natori, Toshimitu Takahashi, Adam Weitemier, Natsuko Nishikawa, Thomas McHugh, Yasuaki Einaga, Shigeru Kitazawa

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Reward-induced burst firing of dopaminergic neurons has mainly been studied in the primate midbrain. Voltammetry allows high-speed detection of dopamine release in the projection area. Although voltammetry has revealed presynaptic modulation of dopamine release in the striatum, to date, reward-induced release in awakened brains has been recorded only in rodents. To make such recordings, it is possible to use conventional carbon fibres in monkey brains but the use of these fibres is limited by their physical fragility. In this study, constant-potential amperometry was applied to novel diamond microelectrodes for high-speed detection of dopamine. In primate brains during Pavlovian cue-reward trials, a sharp response to a reward cue was detected in the caudate of Japanese monkeys. Overall, this method allows measurements of monoamine release in specific target areas of large brains, the findings from which will expand the knowledge of reward responses obtained by unit recordings.

Original languageEnglish
Pages (from-to)49-62
Number of pages14
JournalNeuroscience Research
Volume71
Issue number1
DOIs
Publication statusPublished - 2011 Sep

Fingerprint

Diamond
Microelectrodes
Reward
Haplorhini
Dopamine
Brain
Primates
Cues
Dopaminergic Neurons
Macaca
Mesencephalon
Rodentia

Keywords

  • Amperometry
  • Boron-doped diamond
  • Caudate
  • Dopamine
  • Primate
  • Reward
  • Striatum
  • Voltammetry

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Phasic reward responses in the monkey striatum as detected by voltammetry with diamond microelectrodes. / Yoshimi, Kenji; Naya, Yuuki; Mitani, Naoko; Kato, Taisuke; Inoue, Masato; Natori, Shihoko; Takahashi, Toshimitu; Weitemier, Adam; Nishikawa, Natsuko; McHugh, Thomas; Einaga, Yasuaki; Kitazawa, Shigeru.

In: Neuroscience Research, Vol. 71, No. 1, 09.2011, p. 49-62.

Research output: Contribution to journalArticle

Yoshimi, K, Naya, Y, Mitani, N, Kato, T, Inoue, M, Natori, S, Takahashi, T, Weitemier, A, Nishikawa, N, McHugh, T, Einaga, Y & Kitazawa, S 2011, 'Phasic reward responses in the monkey striatum as detected by voltammetry with diamond microelectrodes', Neuroscience Research, vol. 71, no. 1, pp. 49-62. https://doi.org/10.1016/j.neures.2011.05.013
Yoshimi, Kenji ; Naya, Yuuki ; Mitani, Naoko ; Kato, Taisuke ; Inoue, Masato ; Natori, Shihoko ; Takahashi, Toshimitu ; Weitemier, Adam ; Nishikawa, Natsuko ; McHugh, Thomas ; Einaga, Yasuaki ; Kitazawa, Shigeru. / Phasic reward responses in the monkey striatum as detected by voltammetry with diamond microelectrodes. In: Neuroscience Research. 2011 ; Vol. 71, No. 1. pp. 49-62.
@article{a72c380f0e514cc89bfca98c3db28fac,
title = "Phasic reward responses in the monkey striatum as detected by voltammetry with diamond microelectrodes",
abstract = "Reward-induced burst firing of dopaminergic neurons has mainly been studied in the primate midbrain. Voltammetry allows high-speed detection of dopamine release in the projection area. Although voltammetry has revealed presynaptic modulation of dopamine release in the striatum, to date, reward-induced release in awakened brains has been recorded only in rodents. To make such recordings, it is possible to use conventional carbon fibres in monkey brains but the use of these fibres is limited by their physical fragility. In this study, constant-potential amperometry was applied to novel diamond microelectrodes for high-speed detection of dopamine. In primate brains during Pavlovian cue-reward trials, a sharp response to a reward cue was detected in the caudate of Japanese monkeys. Overall, this method allows measurements of monoamine release in specific target areas of large brains, the findings from which will expand the knowledge of reward responses obtained by unit recordings.",
keywords = "Amperometry, Boron-doped diamond, Caudate, Dopamine, Primate, Reward, Striatum, Voltammetry",
author = "Kenji Yoshimi and Yuuki Naya and Naoko Mitani and Taisuke Kato and Masato Inoue and Shihoko Natori and Toshimitu Takahashi and Adam Weitemier and Natsuko Nishikawa and Thomas McHugh and Yasuaki Einaga and Shigeru Kitazawa",
year = "2011",
month = "9",
doi = "10.1016/j.neures.2011.05.013",
language = "English",
volume = "71",
pages = "49--62",
journal = "Neuroscience Research",
issn = "0168-0102",
publisher = "Elsevier Ireland Ltd",
number = "1",

}

TY - JOUR

T1 - Phasic reward responses in the monkey striatum as detected by voltammetry with diamond microelectrodes

AU - Yoshimi, Kenji

AU - Naya, Yuuki

AU - Mitani, Naoko

AU - Kato, Taisuke

AU - Inoue, Masato

AU - Natori, Shihoko

AU - Takahashi, Toshimitu

AU - Weitemier, Adam

AU - Nishikawa, Natsuko

AU - McHugh, Thomas

AU - Einaga, Yasuaki

AU - Kitazawa, Shigeru

PY - 2011/9

Y1 - 2011/9

N2 - Reward-induced burst firing of dopaminergic neurons has mainly been studied in the primate midbrain. Voltammetry allows high-speed detection of dopamine release in the projection area. Although voltammetry has revealed presynaptic modulation of dopamine release in the striatum, to date, reward-induced release in awakened brains has been recorded only in rodents. To make such recordings, it is possible to use conventional carbon fibres in monkey brains but the use of these fibres is limited by their physical fragility. In this study, constant-potential amperometry was applied to novel diamond microelectrodes for high-speed detection of dopamine. In primate brains during Pavlovian cue-reward trials, a sharp response to a reward cue was detected in the caudate of Japanese monkeys. Overall, this method allows measurements of monoamine release in specific target areas of large brains, the findings from which will expand the knowledge of reward responses obtained by unit recordings.

AB - Reward-induced burst firing of dopaminergic neurons has mainly been studied in the primate midbrain. Voltammetry allows high-speed detection of dopamine release in the projection area. Although voltammetry has revealed presynaptic modulation of dopamine release in the striatum, to date, reward-induced release in awakened brains has been recorded only in rodents. To make such recordings, it is possible to use conventional carbon fibres in monkey brains but the use of these fibres is limited by their physical fragility. In this study, constant-potential amperometry was applied to novel diamond microelectrodes for high-speed detection of dopamine. In primate brains during Pavlovian cue-reward trials, a sharp response to a reward cue was detected in the caudate of Japanese monkeys. Overall, this method allows measurements of monoamine release in specific target areas of large brains, the findings from which will expand the knowledge of reward responses obtained by unit recordings.

KW - Amperometry

KW - Boron-doped diamond

KW - Caudate

KW - Dopamine

KW - Primate

KW - Reward

KW - Striatum

KW - Voltammetry

UR - http://www.scopus.com/inward/record.url?scp=79960910974&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79960910974&partnerID=8YFLogxK

U2 - 10.1016/j.neures.2011.05.013

DO - 10.1016/j.neures.2011.05.013

M3 - Article

C2 - 21645558

AN - SCOPUS:79960910974

VL - 71

SP - 49

EP - 62

JO - Neuroscience Research

JF - Neuroscience Research

SN - 0168-0102

IS - 1

ER -