Phenylethanoid glycosides targeting mammalian DNA polymerases

Akira Iida, Fumiyuki Kiuchi, Michiho Ito, Gisho Honda, Yoshiyuki Mizushina, Horomi Yoshida, Kanat Sarsenbaev

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


In our continuing search to discover bioactive compounds from medicinal plants, a methanolic extract of Verbascum songaricum collected in Kazakhstan was investigated. Activity-guided fractionation of the extract prepared from the plant, using a sensitive assay to monitor DNA polymerase reactions, resulted in the isolation of two known phenylethanoid glycosides, poliumoside (1) and verbascoside (2). Glycoside 1 was shown to inhibit mammalian DNA polymerases α, β, δ and ε with IC50 values of 42, 23, 35 and 9 [μM, respectively, while those of glycoside 2 were all more than 100 [μM.

Original languageEnglish
Pages (from-to)146-149
Number of pages4
JournalNatural Medicines
Issue number4
Publication statusPublished - 2003 Aug
Externally publishedYes


  • DNA polymerase inhibition
  • Poliumoside
  • Verbascoside, phenylethanoid glycoside
  • Verbascum songaricum

ASJC Scopus subject areas

  • Molecular Medicine


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