Phorbol esters with Wnt signal-augmenting effects isolated from Excoecaria indica

Tatsuhiro Yamaguchi, Kazufumi Toume, Midori A. Arai, Firoj Ahmed, Samir K. Sadhu, Masami Ishibashi

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

A screening of natural products using a luciferase assay targeting the Wnt signaling pathway was carried out, and the bioassay-guided fractionation of Excoecaria indica (Euphorbiaceae) collected from Bangladesh afforded three phorbol esters (1 - 3). These compounds exhibited Wnt signal-augmenting effects with 1 causing a 25-fold increase in TCF/β-catenin (TOP) transcriptional activity at 95 nM.

Original languageEnglish
Pages (from-to)475-477
Number of pages3
JournalNatural product communications
Volume7
Issue number4
DOIs
Publication statusPublished - 2012 Apr
Externally publishedYes

Keywords

  • Diterpenoid
  • Euphorbiaceae
  • Wnt signal

ASJC Scopus subject areas

  • Pharmacology
  • Plant Science
  • Drug Discovery
  • Complementary and alternative medicine

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