Phosphoethanolamine Accumulation Protects Cancer Cells under Glutamine Starvation through Downregulation of PCYT2

Tsuyoshi Osawa, Teppei Shimamura, Kyoko Saito, Yoko Hasegawa, Naoko Ishii, Miyuki Nishida, Ritsuko Ando, Ayano Kondo, Muyassar Anwar, Rika Tsuchida, Shinjiro Hino, Akihisa Sakamoto, Kaori Igarashi, Kaori Saitoh, Keiko Kato, Keiko Endo, Shotaro Yamano, Yasuharu Kanki, Yoshihiro Matsumura, Takashi MinamiToshiya Tanaka, Motonobu Anai, Youichiro Wada, Hideki Wanibuchi, Mitsuhiro Hayashi, Akinobu Hamada, Masayuki Yoshida, Shinichi Yachida, Mitsuyoshi Nakao, Juro Sakai, Hiroyuki Aburatani, Masabumi Shibuya, Kentaro Hanada, Satoru Miyano, Tomoyoshi Soga, Tatsuhiko Kodama

Research output: Contribution to journalArticle

Abstract

Osawa et al. find that accumulation of phosphoethanolamine (PEtn) protects cancer cells under glutamine starvation through the downregulation of PCYT2. Glutamine regulates PE biosynthesis through PCYT2, resulting in pro-tumorigenic metabolite PEtn accumulation. PEtn stimulates the tolerance of cancer cells to starvation, and lowered PCYT2 expression correlates with decreased survival in patients.

Original languageEnglish
Pages (from-to)89-103.e7
JournalCell Reports
Volume29
Issue number1
DOIs
Publication statusPublished - 2019 Oct 1

Fingerprint

Starvation
Glutamine
Down-Regulation
Cells
Neoplasms
Biosynthesis
Metabolites
Survival
phosphorylethanolamine

Keywords

  • amino acids
  • cancer metabolism
  • glutamine deprivation
  • hypoxia
  • nutrient starvation
  • PCYT2
  • PE biosynthesis
  • phosphoethanolamine
  • tumor microenvironments

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Osawa, T., Shimamura, T., Saito, K., Hasegawa, Y., Ishii, N., Nishida, M., ... Kodama, T. (2019). Phosphoethanolamine Accumulation Protects Cancer Cells under Glutamine Starvation through Downregulation of PCYT2. Cell Reports, 29(1), 89-103.e7. https://doi.org/10.1016/j.celrep.2019.08.087

Phosphoethanolamine Accumulation Protects Cancer Cells under Glutamine Starvation through Downregulation of PCYT2. / Osawa, Tsuyoshi; Shimamura, Teppei; Saito, Kyoko; Hasegawa, Yoko; Ishii, Naoko; Nishida, Miyuki; Ando, Ritsuko; Kondo, Ayano; Anwar, Muyassar; Tsuchida, Rika; Hino, Shinjiro; Sakamoto, Akihisa; Igarashi, Kaori; Saitoh, Kaori; Kato, Keiko; Endo, Keiko; Yamano, Shotaro; Kanki, Yasuharu; Matsumura, Yoshihiro; Minami, Takashi; Tanaka, Toshiya; Anai, Motonobu; Wada, Youichiro; Wanibuchi, Hideki; Hayashi, Mitsuhiro; Hamada, Akinobu; Yoshida, Masayuki; Yachida, Shinichi; Nakao, Mitsuyoshi; Sakai, Juro; Aburatani, Hiroyuki; Shibuya, Masabumi; Hanada, Kentaro; Miyano, Satoru; Soga, Tomoyoshi; Kodama, Tatsuhiko.

In: Cell Reports, Vol. 29, No. 1, 01.10.2019, p. 89-103.e7.

Research output: Contribution to journalArticle

Osawa, T, Shimamura, T, Saito, K, Hasegawa, Y, Ishii, N, Nishida, M, Ando, R, Kondo, A, Anwar, M, Tsuchida, R, Hino, S, Sakamoto, A, Igarashi, K, Saitoh, K, Kato, K, Endo, K, Yamano, S, Kanki, Y, Matsumura, Y, Minami, T, Tanaka, T, Anai, M, Wada, Y, Wanibuchi, H, Hayashi, M, Hamada, A, Yoshida, M, Yachida, S, Nakao, M, Sakai, J, Aburatani, H, Shibuya, M, Hanada, K, Miyano, S, Soga, T & Kodama, T 2019, 'Phosphoethanolamine Accumulation Protects Cancer Cells under Glutamine Starvation through Downregulation of PCYT2', Cell Reports, vol. 29, no. 1, pp. 89-103.e7. https://doi.org/10.1016/j.celrep.2019.08.087
Osawa, Tsuyoshi ; Shimamura, Teppei ; Saito, Kyoko ; Hasegawa, Yoko ; Ishii, Naoko ; Nishida, Miyuki ; Ando, Ritsuko ; Kondo, Ayano ; Anwar, Muyassar ; Tsuchida, Rika ; Hino, Shinjiro ; Sakamoto, Akihisa ; Igarashi, Kaori ; Saitoh, Kaori ; Kato, Keiko ; Endo, Keiko ; Yamano, Shotaro ; Kanki, Yasuharu ; Matsumura, Yoshihiro ; Minami, Takashi ; Tanaka, Toshiya ; Anai, Motonobu ; Wada, Youichiro ; Wanibuchi, Hideki ; Hayashi, Mitsuhiro ; Hamada, Akinobu ; Yoshida, Masayuki ; Yachida, Shinichi ; Nakao, Mitsuyoshi ; Sakai, Juro ; Aburatani, Hiroyuki ; Shibuya, Masabumi ; Hanada, Kentaro ; Miyano, Satoru ; Soga, Tomoyoshi ; Kodama, Tatsuhiko. / Phosphoethanolamine Accumulation Protects Cancer Cells under Glutamine Starvation through Downregulation of PCYT2. In: Cell Reports. 2019 ; Vol. 29, No. 1. pp. 89-103.e7.
@article{06331d6094fa496086f04ef3f0f6e3ea,
title = "Phosphoethanolamine Accumulation Protects Cancer Cells under Glutamine Starvation through Downregulation of PCYT2",
abstract = "Osawa et al. find that accumulation of phosphoethanolamine (PEtn) protects cancer cells under glutamine starvation through the downregulation of PCYT2. Glutamine regulates PE biosynthesis through PCYT2, resulting in pro-tumorigenic metabolite PEtn accumulation. PEtn stimulates the tolerance of cancer cells to starvation, and lowered PCYT2 expression correlates with decreased survival in patients.",
keywords = "amino acids, cancer metabolism, glutamine deprivation, hypoxia, nutrient starvation, PCYT2, PE biosynthesis, phosphoethanolamine, tumor microenvironments",
author = "Tsuyoshi Osawa and Teppei Shimamura and Kyoko Saito and Yoko Hasegawa and Naoko Ishii and Miyuki Nishida and Ritsuko Ando and Ayano Kondo and Muyassar Anwar and Rika Tsuchida and Shinjiro Hino and Akihisa Sakamoto and Kaori Igarashi and Kaori Saitoh and Keiko Kato and Keiko Endo and Shotaro Yamano and Yasuharu Kanki and Yoshihiro Matsumura and Takashi Minami and Toshiya Tanaka and Motonobu Anai and Youichiro Wada and Hideki Wanibuchi and Mitsuhiro Hayashi and Akinobu Hamada and Masayuki Yoshida and Shinichi Yachida and Mitsuyoshi Nakao and Juro Sakai and Hiroyuki Aburatani and Masabumi Shibuya and Kentaro Hanada and Satoru Miyano and Tomoyoshi Soga and Tatsuhiko Kodama",
year = "2019",
month = "10",
day = "1",
doi = "10.1016/j.celrep.2019.08.087",
language = "English",
volume = "29",
pages = "89--103.e7",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "1",

}

TY - JOUR

T1 - Phosphoethanolamine Accumulation Protects Cancer Cells under Glutamine Starvation through Downregulation of PCYT2

AU - Osawa, Tsuyoshi

AU - Shimamura, Teppei

AU - Saito, Kyoko

AU - Hasegawa, Yoko

AU - Ishii, Naoko

AU - Nishida, Miyuki

AU - Ando, Ritsuko

AU - Kondo, Ayano

AU - Anwar, Muyassar

AU - Tsuchida, Rika

AU - Hino, Shinjiro

AU - Sakamoto, Akihisa

AU - Igarashi, Kaori

AU - Saitoh, Kaori

AU - Kato, Keiko

AU - Endo, Keiko

AU - Yamano, Shotaro

AU - Kanki, Yasuharu

AU - Matsumura, Yoshihiro

AU - Minami, Takashi

AU - Tanaka, Toshiya

AU - Anai, Motonobu

AU - Wada, Youichiro

AU - Wanibuchi, Hideki

AU - Hayashi, Mitsuhiro

AU - Hamada, Akinobu

AU - Yoshida, Masayuki

AU - Yachida, Shinichi

AU - Nakao, Mitsuyoshi

AU - Sakai, Juro

AU - Aburatani, Hiroyuki

AU - Shibuya, Masabumi

AU - Hanada, Kentaro

AU - Miyano, Satoru

AU - Soga, Tomoyoshi

AU - Kodama, Tatsuhiko

PY - 2019/10/1

Y1 - 2019/10/1

N2 - Osawa et al. find that accumulation of phosphoethanolamine (PEtn) protects cancer cells under glutamine starvation through the downregulation of PCYT2. Glutamine regulates PE biosynthesis through PCYT2, resulting in pro-tumorigenic metabolite PEtn accumulation. PEtn stimulates the tolerance of cancer cells to starvation, and lowered PCYT2 expression correlates with decreased survival in patients.

AB - Osawa et al. find that accumulation of phosphoethanolamine (PEtn) protects cancer cells under glutamine starvation through the downregulation of PCYT2. Glutamine regulates PE biosynthesis through PCYT2, resulting in pro-tumorigenic metabolite PEtn accumulation. PEtn stimulates the tolerance of cancer cells to starvation, and lowered PCYT2 expression correlates with decreased survival in patients.

KW - amino acids

KW - cancer metabolism

KW - glutamine deprivation

KW - hypoxia

KW - nutrient starvation

KW - PCYT2

KW - PE biosynthesis

KW - phosphoethanolamine

KW - tumor microenvironments

UR - http://www.scopus.com/inward/record.url?scp=85072271823&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85072271823&partnerID=8YFLogxK

U2 - 10.1016/j.celrep.2019.08.087

DO - 10.1016/j.celrep.2019.08.087

M3 - Article

C2 - 31577958

AN - SCOPUS:85072271823

VL - 29

SP - 89-103.e7

JO - Cell Reports

JF - Cell Reports

SN - 2211-1247

IS - 1

ER -