Phosphorylation of a new member of the bicarbonate cotransporter superfamily

M. Hayashi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Acid-base balance is regulated by cortical collecting duct cells in kidney, where the transporter functions of β-intercalated cells are controlled by such factors as isoproterenol, cyclic adenosine monophosphate (cAMP), and the protein kinase A (PKA) pathway. The apical anion exchanger (AE) in β-intercalated cells is thought to be involved in the secretion of bicarbonate into urine. In isolated cells, the Cl- channel was shown to be activated by isoproterenol via the PKA pathway. The importance of the PKA pathway and phosphorylation in the regulation of its transporter activity is not yet known.

Original languageEnglish
Pages (from-to)462-465
Number of pages4
JournalKidney international
Volume60
Issue number2
DOIs
Publication statusPublished - 2001 Jan 1

Keywords

  • Acid-base homeostasis
  • Apical anion exchanger
  • Chloride channel
  • Intercalated cells
  • Urinary acid secretion
  • β-intercalated cells

ASJC Scopus subject areas

  • Nephrology

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