Photo-degradation of amyloid β by a designed fullerene-sugar hybrid

Yasunori Ishida, Shuho Tanimoto, Daisuke Takahashi, Kazunobu Toshima

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

A purpose-designed fullerene-sugar hybrid effectively inhibited amyloid β peptide aggregation and caused degradation of its monomer and oligomers, which are key compounds in Alzheimer's disease. Degradation was achieved using long-wavelength UV radiation in the absence of any additives and under neutral conditions.

Original languageEnglish
Pages (from-to)212-215
Number of pages4
JournalMedChemComm
Volume1
Issue number3
DOIs
Publication statusPublished - 2010 Sep 1

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry

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