Photo-degradation of amyloid β by a designed fullerene-sugar hybrid

Yasunori Ishida; Shuho Tanimoto; Daisuke Takahashi; Kazunobu Toshima

doi:10.1039/c0md00075b

Photo-degradation of amyloid β by a designed fullerene-sugar hybrid

Yasunori Ishida, Shuho Tanimoto, Daisuke Takahashi, Kazunobu Toshima

Department of Applied Chemistry

Research output: Contribution to journal › Article › peer-review

48 Citations (Scopus)

Abstract

A purpose-designed fullerene-sugar hybrid effectively inhibited amyloid β peptide aggregation and caused degradation of its monomer and oligomers, which are key compounds in Alzheimer's disease. Degradation was achieved using long-wavelength UV radiation in the absence of any additives and under neutral conditions.

Original language	English
Pages (from-to)	212-215
Number of pages	4
Journal	MedChemComm
Volume	1
Issue number	3
DOIs	https://doi.org/10.1039/c0md00075b
Publication status	Published - 2010 Sept 1

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Organic Chemistry

Access to Document

10.1039/c0md00075b

Cite this

@article{e374c20ddeb8477a9a9604d79c5b6357,

title = "Photo-degradation of amyloid β by a designed fullerene-sugar hybrid",

abstract = "A purpose-designed fullerene-sugar hybrid effectively inhibited amyloid β peptide aggregation and caused degradation of its monomer and oligomers, which are key compounds in Alzheimer's disease. Degradation was achieved using long-wavelength UV radiation in the absence of any additives and under neutral conditions.",

author = "Yasunori Ishida and Shuho Tanimoto and Daisuke Takahashi and Kazunobu Toshima",

year = "2010",

month = sep,

day = "1",

doi = "10.1039/c0md00075b",

language = "English",

volume = "1",

pages = "212--215",

journal = "MedChemComm",

issn = "2040-2503",

publisher = "Royal Society of Chemistry",

number = "3",

}

TY - JOUR

T1 - Photo-degradation of amyloid β by a designed fullerene-sugar hybrid

AU - Ishida, Yasunori

AU - Tanimoto, Shuho

AU - Takahashi, Daisuke

AU - Toshima, Kazunobu

PY - 2010/9/1

Y1 - 2010/9/1

N2 - A purpose-designed fullerene-sugar hybrid effectively inhibited amyloid β peptide aggregation and caused degradation of its monomer and oligomers, which are key compounds in Alzheimer's disease. Degradation was achieved using long-wavelength UV radiation in the absence of any additives and under neutral conditions.

AB - A purpose-designed fullerene-sugar hybrid effectively inhibited amyloid β peptide aggregation and caused degradation of its monomer and oligomers, which are key compounds in Alzheimer's disease. Degradation was achieved using long-wavelength UV radiation in the absence of any additives and under neutral conditions.

UR - http://www.scopus.com/inward/record.url?scp=79952497616&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79952497616&partnerID=8YFLogxK

U2 - 10.1039/c0md00075b

DO - 10.1039/c0md00075b

M3 - Article

AN - SCOPUS:79952497616

SN - 2040-2503

VL - 1

SP - 212

EP - 215

JO - MedChemComm

JF - MedChemComm

IS - 3

ER -

Photo-degradation of amyloid β by a designed fullerene-sugar hybrid

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this