Photo-degradation of amyloid β by a designed fullerene-sugar hybrid

Yasunori Ishida, Shuho Tanimoto, Daisuke Takahashi, Kazunobu Toshima

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

A purpose-designed fullerene-sugar hybrid effectively inhibited amyloid β peptide aggregation and caused degradation of its monomer and oligomers, which are key compounds in Alzheimer's disease. Degradation was achieved using long-wavelength UV radiation in the absence of any additives and under neutral conditions.

Original languageEnglish
Pages (from-to)212-215
Number of pages4
JournalMedChemComm
Volume1
Issue number3
DOIs
Publication statusPublished - 2010 Sep

Fingerprint

Fullerenes
Photodegradation
Amyloid
Sugars
Alzheimer Disease
Radiation
Degradation
Peptides
Oligomers
Ultraviolet radiation
Agglomeration
Monomers
Wavelength

ASJC Scopus subject areas

  • Biochemistry
  • Pharmaceutical Science

Cite this

Photo-degradation of amyloid β by a designed fullerene-sugar hybrid. / Ishida, Yasunori; Tanimoto, Shuho; Takahashi, Daisuke; Toshima, Kazunobu.

In: MedChemComm, Vol. 1, No. 3, 09.2010, p. 212-215.

Research output: Contribution to journalArticle

Ishida, Yasunori ; Tanimoto, Shuho ; Takahashi, Daisuke ; Toshima, Kazunobu. / Photo-degradation of amyloid β by a designed fullerene-sugar hybrid. In: MedChemComm. 2010 ; Vol. 1, No. 3. pp. 212-215.
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