Photoacoustic imaging of cerebral blood vessels in a rat for monitoring drug delivery to the brain tissue

Ryota Watanabe, Shunichi Sato, Yasuyuki Tsunoi, Satoko Kawauchi, Hiroshi Ashida, Mitsuhiro Terakawa

Research output: Contribution to journalArticle

Abstract

In general, it is difficult to deliver a drug to the brain transvascularly due to the blood-brain barrier. To develop a method for drug delivery to the brain, a modality that enables imaging both of the cerebral blood vessels and a drug is needed. In this study, we developed a compact photoacoustic imaging system, by which label-free imaging of the cerebral blood vessels in a rat was performed in vivo. By compensating the attenuation of excitation light in brain tissue, blood vessels with diameters larger than 50 μm were visualized in the depth range up to ~2 mm.

Original languageEnglish
Pages (from-to)O-110-O-111
JournalTransactions of Japanese Society for Medical and Biological Engineering
Volume52
DOIs
Publication statusPublished - 2014 Aug 17

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Keywords

  • Blood Brain Barrier
  • Blood vessels
  • Drug delivery
  • Optical fiber
  • Photoacoustic imaging

ASJC Scopus subject areas

  • Biomedical Engineering

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