Photoacoustic imaging of cerebral blood vessels in a rat for monitoring drug delivery to the brain tissue

Ryota Watanabe, Shunichi Sato, Yasuyuki Tsunoi, Satoko Kawauchi, Hiroshi Ashida, Mitsuhiro Terakawa

    Research output: Contribution to journalArticle

    Abstract

    In general, it is difficult to deliver a drug to the brain transvascularly due to the blood-brain barrier. To develop a method for drug delivery to the brain, a modality that enables imaging both of the cerebral blood vessels and a drug is needed. In this study, we developed a compact photoacoustic imaging system, by which label-free imaging of the cerebral blood vessels in a rat was performed in vivo. By compensating the attenuation of excitation light in brain tissue, blood vessels with diameters larger than 50 μm were visualized in the depth range up to ~2 mm.

    Original languageEnglish
    Pages (from-to)O-110-O-111
    JournalTransactions of Japanese Society for Medical and Biological Engineering
    Volume52
    DOIs
    Publication statusPublished - 2014 Aug 17

    Keywords

    • Blood Brain Barrier
    • Blood vessels
    • Drug delivery
    • Optical fiber
    • Photoacoustic imaging

    ASJC Scopus subject areas

    • Biomedical Engineering

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