Photodegradation and inhibition of drug-resistant influenza virus neuraminidase using anthraquinone-sialic acid hybrids

Yusuke Aoki, Shuho Tanimoto, Daisuke Takahashi, Kazunobu Toshima

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

The anthraquinone-sialic acid hybrids designed effectively degraded not only non-drug-resistant neuraminidase but also drug-resistant neuraminidase, which is an important target of anti-influenza therapy. Degradation was achieved using long-wavelength UV radiation in the absence of any additives and under neutral conditions. Moreover, the hybrids efficiently inhibited neuraminidase activities upon photo-irradiation. This journal is

Original languageEnglish
Pages (from-to)1169-1171
Number of pages3
JournalChemical Communications
Volume49
Issue number12
DOIs
Publication statusPublished - 2013 Feb 13

Fingerprint

Anthraquinones
Photodegradation
Neuraminidase
N-Acetylneuraminic Acid
Viruses
Ultraviolet radiation
Irradiation
Degradation
Wavelength
Acids
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Catalysis
  • Chemistry(all)

Cite this

Photodegradation and inhibition of drug-resistant influenza virus neuraminidase using anthraquinone-sialic acid hybrids. / Aoki, Yusuke; Tanimoto, Shuho; Takahashi, Daisuke; Toshima, Kazunobu.

In: Chemical Communications, Vol. 49, No. 12, 13.02.2013, p. 1169-1171.

Research output: Contribution to journalArticle

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