Photodegradation of amyloid β and reduction of its cytotoxicity to PC12 cells using porphyrin derivatives

Ayumi Hirabayashi; Yutaka Shindo; Kotaro Oka; Daisuke Takahashi; Kazunobu Toshima

doi:10.1039/c4cc03791j

Photodegradation of amyloid β and reduction of its cytotoxicity to PC12 cells using porphyrin derivatives

Ayumi Hirabayashi, Yutaka Shindo, Kotaro Oka, Daisuke Takahashi, Kazunobu Toshima

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

Abstract

A purpose-designed porphyrin–peptide hybrid effectively degraded amyloid β monomer and oligomers associated with Alzheimer's disease. Degradation was achieved using light irradiation in the absence of any additives and under neutral conditions. Moreover, the hybrid effectively neutralized the cytotoxicity of amyloid β in PC12 cells upon photoirradiation.

Original language	English
Pages (from-to)	9543-9546
Number of pages	4
Journal	Chemical Communications
Volume	50
Issue number	67
DOIs	https://doi.org/10.1039/c4cc03791j
Publication status	Published - 2014 Jul 24

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

Access to Document

10.1039/c4cc03791j

Cite this

@article{b6f12b7f595343ea98c9767fdb95af2b,

title = "Photodegradation of amyloid β and reduction of its cytotoxicity to PC12 cells using porphyrin derivatives",

abstract = "A purpose-designed porphyrin–peptide hybrid effectively degraded amyloid β monomer and oligomers associated with Alzheimer's disease. Degradation was achieved using light irradiation in the absence of any additives and under neutral conditions. Moreover, the hybrid effectively neutralized the cytotoxicity of amyloid β in PC12 cells upon photoirradiation.",

author = "Ayumi Hirabayashi and Yutaka Shindo and Kotaro Oka and Daisuke Takahashi and Kazunobu Toshima",

year = "2014",

month = jul,

day = "24",

doi = "10.1039/c4cc03791j",

language = "English",

volume = "50",

pages = "9543--9546",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "67",

}

TY - JOUR

T1 - Photodegradation of amyloid β and reduction of its cytotoxicity to PC12 cells using porphyrin derivatives

AU - Hirabayashi, Ayumi

AU - Shindo, Yutaka

AU - Oka, Kotaro

AU - Takahashi, Daisuke

AU - Toshima, Kazunobu

PY - 2014/7/24

Y1 - 2014/7/24

N2 - A purpose-designed porphyrin–peptide hybrid effectively degraded amyloid β monomer and oligomers associated with Alzheimer's disease. Degradation was achieved using light irradiation in the absence of any additives and under neutral conditions. Moreover, the hybrid effectively neutralized the cytotoxicity of amyloid β in PC12 cells upon photoirradiation.

AB - A purpose-designed porphyrin–peptide hybrid effectively degraded amyloid β monomer and oligomers associated with Alzheimer's disease. Degradation was achieved using light irradiation in the absence of any additives and under neutral conditions. Moreover, the hybrid effectively neutralized the cytotoxicity of amyloid β in PC12 cells upon photoirradiation.

UR - http://www.scopus.com/inward/record.url?scp=84905024206&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84905024206&partnerID=8YFLogxK

U2 - 10.1039/c4cc03791j

DO - 10.1039/c4cc03791j

M3 - Article

C2 - 25012260

AN - SCOPUS:84905024206

SN - 1359-7345

VL - 50

SP - 9543

EP - 9546

JO - Chemical Communications

JF - Chemical Communications

IS - 67

ER -

Photodegradation of amyloid β and reduction of its cytotoxicity to PC12 cells using porphyrin derivatives

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this