Photodegradation of amyloid β and reduction of its cytotoxicity to PC12 cells using porphyrin derivatives

Ayumi Hirabayashi, Yutaka Shindo, Kotaro Oka, Daisuke Takahashi, Kazunobu Toshima

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

A purpose-designed porphyrin-peptide hybrid effectively degraded amyloid β monomer and oligomers associated with Alzheimer's disease. Degradation was achieved using light irradiation in the absence of any additives and under neutral conditions. Moreover, the hybrid effectively neutralized the cytotoxicity of amyloid β in PC12 cells upon photoirradiation. This journal is

Original languageEnglish
Pages (from-to)9543-9546
Number of pages4
JournalChemical Communications
Volume50
Issue number67
DOIs
Publication statusPublished - 2014 Aug 28

Fingerprint

Porphyrins
Photodegradation
Cytotoxicity
Amyloid
Derivatives
Oligomers
Peptides
Monomers
Irradiation
Degradation

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Ceramics and Composites
  • Electronic, Optical and Magnetic Materials
  • Surfaces, Coatings and Films
  • Materials Chemistry
  • Metals and Alloys

Cite this

Photodegradation of amyloid β and reduction of its cytotoxicity to PC12 cells using porphyrin derivatives. / Hirabayashi, Ayumi; Shindo, Yutaka; Oka, Kotaro; Takahashi, Daisuke; Toshima, Kazunobu.

In: Chemical Communications, Vol. 50, No. 67, 28.08.2014, p. 9543-9546.

Research output: Contribution to journalArticle

@article{b6f12b7f595343ea98c9767fdb95af2b,
title = "Photodegradation of amyloid β and reduction of its cytotoxicity to PC12 cells using porphyrin derivatives",
abstract = "A purpose-designed porphyrin-peptide hybrid effectively degraded amyloid β monomer and oligomers associated with Alzheimer's disease. Degradation was achieved using light irradiation in the absence of any additives and under neutral conditions. Moreover, the hybrid effectively neutralized the cytotoxicity of amyloid β in PC12 cells upon photoirradiation. This journal is",
author = "Ayumi Hirabayashi and Yutaka Shindo and Kotaro Oka and Daisuke Takahashi and Kazunobu Toshima",
year = "2014",
month = "8",
day = "28",
doi = "10.1039/c4cc03791j",
language = "English",
volume = "50",
pages = "9543--9546",
journal = "Chemical Communications",
issn = "1359-7345",
publisher = "Royal Society of Chemistry",
number = "67",

}

TY - JOUR

T1 - Photodegradation of amyloid β and reduction of its cytotoxicity to PC12 cells using porphyrin derivatives

AU - Hirabayashi, Ayumi

AU - Shindo, Yutaka

AU - Oka, Kotaro

AU - Takahashi, Daisuke

AU - Toshima, Kazunobu

PY - 2014/8/28

Y1 - 2014/8/28

N2 - A purpose-designed porphyrin-peptide hybrid effectively degraded amyloid β monomer and oligomers associated with Alzheimer's disease. Degradation was achieved using light irradiation in the absence of any additives and under neutral conditions. Moreover, the hybrid effectively neutralized the cytotoxicity of amyloid β in PC12 cells upon photoirradiation. This journal is

AB - A purpose-designed porphyrin-peptide hybrid effectively degraded amyloid β monomer and oligomers associated with Alzheimer's disease. Degradation was achieved using light irradiation in the absence of any additives and under neutral conditions. Moreover, the hybrid effectively neutralized the cytotoxicity of amyloid β in PC12 cells upon photoirradiation. This journal is

UR - http://www.scopus.com/inward/record.url?scp=84905024206&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84905024206&partnerID=8YFLogxK

U2 - 10.1039/c4cc03791j

DO - 10.1039/c4cc03791j

M3 - Article

C2 - 25012260

AN - SCOPUS:84905024206

VL - 50

SP - 9543

EP - 9546

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 67

ER -