Photodegradation of amyloid β and reduction of its cytotoxicity to PC12 cells using porphyrin derivatives

Ayumi Hirabayashi, Yutaka Shindo, Kotaro Oka, Daisuke Takahashi, Kazunobu Toshima

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

A purpose-designed porphyrin–peptide hybrid effectively degraded amyloid β monomer and oligomers associated with Alzheimer's disease. Degradation was achieved using light irradiation in the absence of any additives and under neutral conditions. Moreover, the hybrid effectively neutralized the cytotoxicity of amyloid β in PC12 cells upon photoirradiation.

Original languageEnglish
Pages (from-to)9543-9546
Number of pages4
JournalChemical Communications
Volume50
Issue number67
DOIs
Publication statusPublished - 2014 Jul 24

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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