Photodegradation of target oligosaccharides by light-activated small molecules

Daisuke Takahashi, Shingo Hirono, Chigusa Hayashi, Masayuki Igarashi, Yoshio Nishimura, Kazunobu Toshima

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Shine on, shine on: The designed anthraquinone/boronic acid hybrid 1 selectively caused the degradation of oligosaccharides that have a β-D-galactofuranoside residue, which is a unique component in mycobacterial cell walls. Degradation was achieved using long-wavelength UV radiation in the absence of any additives and under neutral conditions.

Original languageEnglish
Pages (from-to)10096-10100
Number of pages5
JournalAngewandte Chemie - International Edition
Volume49
Issue number52
DOIs
Publication statusPublished - 2010 Dec 27

Fingerprint

Oligosaccharides
Photodegradation
Boronic Acids
Degradation
Anthraquinones
Molecules
Ultraviolet radiation
Cells
Wavelength
Acids

Keywords

  • anthraquinones
  • boronic acids
  • carbohydrates
  • Mycobacterium tuberculosis
  • photochemistry

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

Cite this

Photodegradation of target oligosaccharides by light-activated small molecules. / Takahashi, Daisuke; Hirono, Shingo; Hayashi, Chigusa; Igarashi, Masayuki; Nishimura, Yoshio; Toshima, Kazunobu.

In: Angewandte Chemie - International Edition, Vol. 49, No. 52, 27.12.2010, p. 10096-10100.

Research output: Contribution to journalArticle

Takahashi, Daisuke ; Hirono, Shingo ; Hayashi, Chigusa ; Igarashi, Masayuki ; Nishimura, Yoshio ; Toshima, Kazunobu. / Photodegradation of target oligosaccharides by light-activated small molecules. In: Angewandte Chemie - International Edition. 2010 ; Vol. 49, No. 52. pp. 10096-10100.
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