Photopolymerized hydrogel microbeads generated by simultaneous UV irradiation with centrifuge

Yuta Kurashina, Hiroaki Onoe

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)

Abstract

We propose a method to fabricate photopolymerized hydrogel microbeads using UV irradiation with centrifuge-based particle generation. Without using oil phase and tubing/pumping apparatus, centrifugally generated microdroplets of photo-crosslinkable monomer solution can be polymerized by UV irradiation with the assistant of ionic gelation of alginate hydrogel. We developed the centrifugal microfluidic device with UV LEDs, demonstrated the generation of hydrogel microbeads composed of poly(N-isopropylacrylamide) (pNiPAM) and calcium alginate, and confirmed thermal responsivity of fabricated pNiPAM/alginate hydrogel microbeads. We envision that our proposed method would be useful for generating functional hydrogel microbeads for drug delivery systems and health monitoring biochemical sensors for in vivo applications.

Original languageEnglish
Title of host publication22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
PublisherChemical and Biological Microsystems Society
Pages547-548
Number of pages2
ISBN (Electronic)9781510897571
Publication statusPublished - 2018 Jan 1
Event22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018 - Kaohsiung, Taiwan, Province of China
Duration: 2018 Nov 112018 Nov 15

Publication series

Name22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
Volume1

Conference

Conference22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2018
CountryTaiwan, Province of China
CityKaohsiung
Period18/11/1118/11/15

Keywords

  • Centrifugal microfluidics
  • Microparticles
  • N-isopropylacrylamide
  • Photo polymerization
  • Temperature-responsive hydrogel

ASJC Scopus subject areas

  • Chemistry(all)
  • Bioengineering
  • Chemical Engineering (miscellaneous)
  • Control and Systems Engineering

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