Photosensitization reaction-induced electrical blockade in myocardial tissue

A. Ito, S. Hosokawa, S. Miyoshi, K. Soejima, Tsunenori Arai

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

We proposed the application of photodynamic therapy (PDT) as a new type of atrial fibrillation treatment. PDT is well known as a practical cancer treatment using cytotoxicity of reactive oxygen species generated by the photochemical interaction. We predicted that the photocytotoxic effect induced by PDT might cause electrical blockade in myocardial tissue. We studied the electrical blockade induced by the PDT with talaporfin sodium in vitro, ex vivo, and in vivo. The cell lethality measurement using rat cardiac myocytes confirmed the PDT-induced photocytotoxic effect and its dependence on the loading time of the photosensitizer. In ex vivo experiment using rat right ventricle, the PDT caused a shutdown of the stimulated electrical signal propagation. The long-lasting atrioventricular block induced by the PDT was obtained in vivo experiment with rat heart. These results revealed the possibility of atrial fibrillation treatment with the PDT.

Original languageEnglish
Title of host publicationProceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology"
Pages4361-4363
Number of pages3
Publication statusPublished - 2008
Event30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - Vancouver, BC, Canada
Duration: 2008 Aug 202008 Aug 25

Other

Other30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08
CountryCanada
CityVancouver, BC
Period08/8/2008/8/25

Fingerprint

Photosensitivity Disorders
Photodynamic therapy
Photochemotherapy
Tissue
Rats
Atrial Fibrillation
Photosensitizing Agents
Photosensitizers
Oncology
Atrioventricular Block
Cytotoxicity
Cardiac Myocytes
Heart Ventricles
Reactive Oxygen Species
Therapeutics
Experiments
Sodium
Oxygen

ASJC Scopus subject areas

  • Computer Vision and Pattern Recognition
  • Signal Processing
  • Biomedical Engineering
  • Health Informatics

Cite this

Ito, A., Hosokawa, S., Miyoshi, S., Soejima, K., & Arai, T. (2008). Photosensitization reaction-induced electrical blockade in myocardial tissue. In Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology" (pp. 4361-4363). [4650176]

Photosensitization reaction-induced electrical blockade in myocardial tissue. / Ito, A.; Hosokawa, S.; Miyoshi, S.; Soejima, K.; Arai, Tsunenori.

Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology". 2008. p. 4361-4363 4650176.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Ito, A, Hosokawa, S, Miyoshi, S, Soejima, K & Arai, T 2008, Photosensitization reaction-induced electrical blockade in myocardial tissue. in Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology"., 4650176, pp. 4361-4363, 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08, Vancouver, BC, Canada, 08/8/20.
Ito A, Hosokawa S, Miyoshi S, Soejima K, Arai T. Photosensitization reaction-induced electrical blockade in myocardial tissue. In Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology". 2008. p. 4361-4363. 4650176
Ito, A. ; Hosokawa, S. ; Miyoshi, S. ; Soejima, K. ; Arai, Tsunenori. / Photosensitization reaction-induced electrical blockade in myocardial tissue. Proceedings of the 30th Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS'08 - "Personalized Healthcare through Technology". 2008. pp. 4361-4363
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