Physical inactivity, prolonged sedentary behaviors, and use of visual display terminals as potential risk factors for dry eye disease: JPHC-NEXT study

JPHC-NEXT Study Group

Research output: Contribution to journalArticle

Abstract

Purpose: This population-based, cross-sectional study was performed to assess the influence of life-style modalities, including physical activity, sedentary behaviors, and visual display terminal (VDT) use, on the prevalence of dry eye disease (DED). Methods: The study included a total of 102,582 participants aged 40–74 years, from the Japan Public Health Center-based Prospective Study for the Next Generation, a large nationwide prospective ongoing Japanese cohort study. Logistic regression analyses were used to investigate the relationship of total and leisure-time physical activity, duration of sedentary behaviors, and VDT use (hours/day) with DED. Results: Among 47,346 men and 55,236 women, 25,234 (8315 males and 16,919 females) cases of DED were documented. Total physical activity was significantly related to decreased DED in both sexes; for the highest vs. lowest total physical activity quartiles, the multivariable-adjusted odds ratios (ORs) for DED were 0.90 (95% confidence interval [CI], 0.84–0.97; Ptrend<0.03) and 0.91 (95% CI, 0.86–0.95; Ptrend<0.001) for men and women, respectively. Conversely, prolonged sedentary behaviors and VDT use had significantly higher prevalence of DED in both sexes (Ptrend<0.001). Notably, the favorable effect of total physical activity on decreased DED in women was more prevalent with prolonged VDT use (≥2 h/day) (Pinteraction<0.01). In men, the duration of VDT use or sitting was a significant modifier of the inverse relationship between leisure-time physical activity and DED (Pinteraction<0.05). Conclusions: Physical inactivity, prolonged sedentary behaviors, and use of VDT were related to increased susceptibility to DED among middle-aged to older Japanese adults.

Original languageEnglish
JournalOcular Surface
DOIs
Publication statusAccepted/In press - 2019 Jan 1

Fingerprint

Eye Diseases
Exercise
Leisure Activities
Confidence Intervals
Life Style
Japan
Cohort Studies
Public Health
Cross-Sectional Studies
Logistic Models
Odds Ratio
Regression Analysis
Prospective Studies

Keywords

  • Asians
  • Dry eye disease
  • Exercise
  • Lifestyle
  • Middle aged
  • Ocular disturbance
  • Sedentary behaviors
  • VDT work

ASJC Scopus subject areas

  • Ophthalmology

Cite this

@article{7aaedfa66d21423e9e778d48d33e9bac,
title = "Physical inactivity, prolonged sedentary behaviors, and use of visual display terminals as potential risk factors for dry eye disease: JPHC-NEXT study",
abstract = "Purpose: This population-based, cross-sectional study was performed to assess the influence of life-style modalities, including physical activity, sedentary behaviors, and visual display terminal (VDT) use, on the prevalence of dry eye disease (DED). Methods: The study included a total of 102,582 participants aged 40–74 years, from the Japan Public Health Center-based Prospective Study for the Next Generation, a large nationwide prospective ongoing Japanese cohort study. Logistic regression analyses were used to investigate the relationship of total and leisure-time physical activity, duration of sedentary behaviors, and VDT use (hours/day) with DED. Results: Among 47,346 men and 55,236 women, 25,234 (8315 males and 16,919 females) cases of DED were documented. Total physical activity was significantly related to decreased DED in both sexes; for the highest vs. lowest total physical activity quartiles, the multivariable-adjusted odds ratios (ORs) for DED were 0.90 (95{\%} confidence interval [CI], 0.84–0.97; Ptrend<0.03) and 0.91 (95{\%} CI, 0.86–0.95; Ptrend<0.001) for men and women, respectively. Conversely, prolonged sedentary behaviors and VDT use had significantly higher prevalence of DED in both sexes (Ptrend<0.001). Notably, the favorable effect of total physical activity on decreased DED in women was more prevalent with prolonged VDT use (≥2 h/day) (Pinteraction<0.01). In men, the duration of VDT use or sitting was a significant modifier of the inverse relationship between leisure-time physical activity and DED (Pinteraction<0.05). Conclusions: Physical inactivity, prolonged sedentary behaviors, and use of VDT were related to increased susceptibility to DED among middle-aged to older Japanese adults.",
keywords = "Asians, Dry eye disease, Exercise, Lifestyle, Middle aged, Ocular disturbance, Sedentary behaviors, VDT work",
author = "{JPHC-NEXT Study Group} and Akiko Hanyuda and Norie Sawada and Miki Uchino and Motoko Kawashima and Kenya Yuki and Kazuo Tsubota and Kazumasa Yamagishi and Hiroyasu Iso and Nobufumi Yasuda and Isao Saito and Tadahiro Kato and Yasuyo Abe and Kazuhiko Arima and Kozo Tanno and Kiyomi Sakata and Taichi Shimazu and Taiki Yamaji and Atsushi Goto and Manami Inoue and Motoki Iwasaki and Shoichiro Tsugane",
year = "2019",
month = "1",
day = "1",
doi = "10.1016/j.jtos.2019.09.007",
language = "English",
journal = "Ocular Surface",
issn = "1542-0124",
publisher = "Ethis Communications, Inc.",

}

TY - JOUR

T1 - Physical inactivity, prolonged sedentary behaviors, and use of visual display terminals as potential risk factors for dry eye disease

T2 - JPHC-NEXT study

AU - JPHC-NEXT Study Group

AU - Hanyuda, Akiko

AU - Sawada, Norie

AU - Uchino, Miki

AU - Kawashima, Motoko

AU - Yuki, Kenya

AU - Tsubota, Kazuo

AU - Yamagishi, Kazumasa

AU - Iso, Hiroyasu

AU - Yasuda, Nobufumi

AU - Saito, Isao

AU - Kato, Tadahiro

AU - Abe, Yasuyo

AU - Arima, Kazuhiko

AU - Tanno, Kozo

AU - Sakata, Kiyomi

AU - Shimazu, Taichi

AU - Yamaji, Taiki

AU - Goto, Atsushi

AU - Inoue, Manami

AU - Iwasaki, Motoki

AU - Tsugane, Shoichiro

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Purpose: This population-based, cross-sectional study was performed to assess the influence of life-style modalities, including physical activity, sedentary behaviors, and visual display terminal (VDT) use, on the prevalence of dry eye disease (DED). Methods: The study included a total of 102,582 participants aged 40–74 years, from the Japan Public Health Center-based Prospective Study for the Next Generation, a large nationwide prospective ongoing Japanese cohort study. Logistic regression analyses were used to investigate the relationship of total and leisure-time physical activity, duration of sedentary behaviors, and VDT use (hours/day) with DED. Results: Among 47,346 men and 55,236 women, 25,234 (8315 males and 16,919 females) cases of DED were documented. Total physical activity was significantly related to decreased DED in both sexes; for the highest vs. lowest total physical activity quartiles, the multivariable-adjusted odds ratios (ORs) for DED were 0.90 (95% confidence interval [CI], 0.84–0.97; Ptrend<0.03) and 0.91 (95% CI, 0.86–0.95; Ptrend<0.001) for men and women, respectively. Conversely, prolonged sedentary behaviors and VDT use had significantly higher prevalence of DED in both sexes (Ptrend<0.001). Notably, the favorable effect of total physical activity on decreased DED in women was more prevalent with prolonged VDT use (≥2 h/day) (Pinteraction<0.01). In men, the duration of VDT use or sitting was a significant modifier of the inverse relationship between leisure-time physical activity and DED (Pinteraction<0.05). Conclusions: Physical inactivity, prolonged sedentary behaviors, and use of VDT were related to increased susceptibility to DED among middle-aged to older Japanese adults.

AB - Purpose: This population-based, cross-sectional study was performed to assess the influence of life-style modalities, including physical activity, sedentary behaviors, and visual display terminal (VDT) use, on the prevalence of dry eye disease (DED). Methods: The study included a total of 102,582 participants aged 40–74 years, from the Japan Public Health Center-based Prospective Study for the Next Generation, a large nationwide prospective ongoing Japanese cohort study. Logistic regression analyses were used to investigate the relationship of total and leisure-time physical activity, duration of sedentary behaviors, and VDT use (hours/day) with DED. Results: Among 47,346 men and 55,236 women, 25,234 (8315 males and 16,919 females) cases of DED were documented. Total physical activity was significantly related to decreased DED in both sexes; for the highest vs. lowest total physical activity quartiles, the multivariable-adjusted odds ratios (ORs) for DED were 0.90 (95% confidence interval [CI], 0.84–0.97; Ptrend<0.03) and 0.91 (95% CI, 0.86–0.95; Ptrend<0.001) for men and women, respectively. Conversely, prolonged sedentary behaviors and VDT use had significantly higher prevalence of DED in both sexes (Ptrend<0.001). Notably, the favorable effect of total physical activity on decreased DED in women was more prevalent with prolonged VDT use (≥2 h/day) (Pinteraction<0.01). In men, the duration of VDT use or sitting was a significant modifier of the inverse relationship between leisure-time physical activity and DED (Pinteraction<0.05). Conclusions: Physical inactivity, prolonged sedentary behaviors, and use of VDT were related to increased susceptibility to DED among middle-aged to older Japanese adults.

KW - Asians

KW - Dry eye disease

KW - Exercise

KW - Lifestyle

KW - Middle aged

KW - Ocular disturbance

KW - Sedentary behaviors

KW - VDT work

UR - http://www.scopus.com/inward/record.url?scp=85072690727&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85072690727&partnerID=8YFLogxK

U2 - 10.1016/j.jtos.2019.09.007

DO - 10.1016/j.jtos.2019.09.007

M3 - Article

AN - SCOPUS:85072690727

JO - Ocular Surface

JF - Ocular Surface

SN - 1542-0124

ER -