Physicochemical Aspects of the Plasmodium chabaudi -Infected Erythrocyte

Eri H. Hayakawa, Seiki Kobayashi, Hiroyuki Matsuoka

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Membrane electrochemical potential is a feature of the molecular profile of the cell membrane and the two-dimensional arrangement of its charge-bearing molecules. Plasmodium species, the causative agents of malaria, are intracellular parasites that remodel host erythrocytes by expressing their own proteins on erythrocyte membranes. Although various aspects of the modifications made to the host erythrocyte membrane have been extensively studied in some human Plasmodium species (such as Plasmodium falciparum), details of the structural and molecular biological modifications made to host erythrocytes by nonhuman Plasmodium parasites have not been studied. We employed zeta potential analysis of erythrocytes parasitized by P. chabaudi, a nonhuman Plasmodium parasite. From these measurements, we found that the surface potential shift was more negative for P. chabaudi-infected erythrocytes than for P. falciparum-infected erythrocytes. However, electron microscopic analysis of the surface of P. chabaudi-infected erythrocytes did not reveal any modifications as compared with nonparasitized erythrocytes. These results suggest that differences in the membrane modifications found herein represent unique attributes related to the pathogenesis profiles of the two different malaria parasite species in different host animals and that these features have been acquired through parasite adaptations acquired over long evolutionary time periods.

Original languageEnglish
Article number642729
JournalBioMed Research International
Volume2015
DOIs
Publication statusPublished - 2015

Fingerprint

Plasmodium chabaudi
Erythrocytes
Plasmodium
Parasites
Membranes
Bearings (structural)
Erythrocyte Membrane
Plasmodium falciparum
Malaria
Zeta potential
Cell membranes
Animals
Membrane Potentials
Molecules
Electrons
Cell Membrane
Proteins

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Physicochemical Aspects of the Plasmodium chabaudi -Infected Erythrocyte. / Hayakawa, Eri H.; Kobayashi, Seiki; Matsuoka, Hiroyuki.

In: BioMed Research International, Vol. 2015, 642729, 2015.

Research output: Contribution to journalArticle

Hayakawa, Eri H. ; Kobayashi, Seiki ; Matsuoka, Hiroyuki. / Physicochemical Aspects of the Plasmodium chabaudi -Infected Erythrocyte. In: BioMed Research International. 2015 ; Vol. 2015.
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