Physicochemical properties of amphoteric β‐lactam antibiotics II: Solubility and dissolution behavior of aminocephalosporins as a function of pH

Akira Tsuji, Emi Nakashima, Tsukinaka Yamana

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The solubility of aminocephalosporins in aqueous solution at 37° and an ionic strength of 0.5 exhibited U‐shaped curves against pH. At their isoelectric pH, cephradine monohydrate was the most soluble, followed by cephalexin monohydrate and cephaloglycin dihydrate, with intrinsic solubilities of 26.0, 17.2, and 14.8 mg/ml, respectively. The dissolution rate constants from the rotating disk were also determined as a function of the pH of the dissolution medium and interpreted reasonably by the simultaneous dissociation equilibrium reaction and the diffusion kinetics model. Energies for the solubility and dissolution were determined for these three aminocephalosporins.

Original languageEnglish
Pages (from-to)308-311
Number of pages4
JournalJournal of Pharmaceutical Sciences
Issue number3
Publication statusPublished - 1979 Mar



  • Aminocephalosporins, various—solubility and dissolution, effect of pH
  • Antibacterials—various aminocephalosporins, solubility and dissolution, effect of pH
  • Dissolution—various aminocephalosporins, effect of pH
  • Solubility—various aminocephalosporins, effect of pH
  • β‐Lactam antibiotics—various aminocephalosporins, solubility and dissolution, effect of pH

ASJC Scopus subject areas

  • Pharmaceutical Science

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