Physicochemical properties of pDNA/chitosan complexes as gene delivery systems

Kenji Hagiwara, Riany Anastasia, Mitsuhiro Nakata, Toshinori Sato

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Successful gene therapy depends on the development of effective gene carriers. Naturally occurring chitosan has been employed widely as a non-viral gene carrier because of its low toxicity, low immunogenicity, biocompatibility, and biodegradability. In this review, we summarize the utilization of chitosan, modified chitosan, and chitosan-containing ternary complexes as gene carriers. In particular, we discuss the influence of the physicochemical features of pDNA/chitosan complexes on their functions, such as stability and gene transfer into cells.

Original languageEnglish
Pages (from-to)329-339
Number of pages11
JournalCurrent Drug Discovery Technologies
Volume8
Issue number4
DOIs
Publication statusPublished - 2011 Dec 1

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Keywords

  • Atomic force microscopy
  • Cell transfection
  • Chitosan
  • DNA complex
  • Gene delivery system
  • Intracellular trafficking
  • Morphology
  • Sugar-modified chitosan

ASJC Scopus subject areas

  • Drug Discovery

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