Pick's disease with Pick bodies: An unusual autopsy case showing degeneration of the pontine nucleus, dentate nucleus, Clarke's column, and lower motor neuron

Tatsuro Oda; Kuniaki Tsuchiya; Tetsuaki Arai; Takashi Togo; Hirotake Uchikado; Rohan De Silva; Andrew Lees; Haruhiko Akiyama; Chie Haga; Kenji Ikeda; Motoichiro Kato; Yuji Kato; Tsunekatsu Hara; Mitsumoto Onaya; Koji Hori; Hiroshi Teramoto; Itaru Tominaga

doi:10.1111/j.1440-1789.2006.00744.x

Pick's disease with Pick bodies: An unusual autopsy case showing degeneration of the pontine nucleus, dentate nucleus, Clarke's column, and lower motor neuron

Tatsuro Oda, Kuniaki Tsuchiya, Tetsuaki Arai, Takashi Togo, Hirotake Uchikado, Rohan De Silva, Andrew Lees, Haruhiko Akiyama, Chie Haga, Kenji Ikeda, Motoichiro Kato, Yuji Kato, Tsunekatsu Hara, Mitsumoto Onaya, Koji Hori, Hiroshi Teramoto, Itaru Tominaga

School of Medicine

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

We report a 51-year-old female with Pick's disease with Pick bodies (PDPB) showing a brainweight of 530 g. This case was considered to be a very rare case of PDPB, in which the lesion developed in the temporal and frontal lobes and later spread to the parietal lobe, occipital lobe, brainstem, cerebellum and spinal cord. This case showed very atypical clinicopathological findings. Clinically, bulging eyes and myoclonus were observed. Neuropathologically, Pick bodies were widely distributed beyond the usual distribution areas to the parietal cortices, occipital cortices, dentate nuclei, motor neuron nuclei in the brain stem, and spinal cord. The atypical clinical symptoms and the widespread neuropathological abnormalities observed in this case seem to represent an extremely extended form of PDPB.

Original language	English
Pages (from-to)	81-89
Number of pages	9
Journal	Neuropathology
Volume	27
Issue number	1
DOIs	https://doi.org/10.1111/j.1440-1789.2006.00744.x
Publication status	Published - 2007 Feb

Keywords

Bulging eyes
Myoclonus
Pick body
Pick's disease
Tau
Topography

ASJC Scopus subject areas

Pathology and Forensic Medicine
Clinical Neurology

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10.1111/j.1440-1789.2006.00744.x

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Oda, T., Tsuchiya, K., Arai, T., Togo, T., Uchikado, H., De Silva, R., Lees, A., Akiyama, H., Haga, C., Ikeda, K., Kato, M., Kato, Y., Hara, T., Onaya, M., Hori, K., Teramoto, H., & Tominaga, I. (2007). Pick's disease with Pick bodies: An unusual autopsy case showing degeneration of the pontine nucleus, dentate nucleus, Clarke's column, and lower motor neuron. Neuropathology, 27(1), 81-89. https://doi.org/10.1111/j.1440-1789.2006.00744.x

Oda, T, Tsuchiya, K, Arai, T, Togo, T, Uchikado, H, De Silva, R, Lees, A, Akiyama, H, Haga, C, Ikeda, K, Kato, M, Kato, Y, Hara, T, Onaya, M, Hori, K, Teramoto, H & Tominaga, I 2007, 'Pick's disease with Pick bodies: An unusual autopsy case showing degeneration of the pontine nucleus, dentate nucleus, Clarke's column, and lower motor neuron', Neuropathology, vol. 27, no. 1, pp. 81-89. https://doi.org/10.1111/j.1440-1789.2006.00744.x

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abstract = "We report a 51-year-old female with Pick's disease with Pick bodies (PDPB) showing a brainweight of 530 g. This case was considered to be a very rare case of PDPB, in which the lesion developed in the temporal and frontal lobes and later spread to the parietal lobe, occipital lobe, brainstem, cerebellum and spinal cord. This case showed very atypical clinicopathological findings. Clinically, bulging eyes and myoclonus were observed. Neuropathologically, Pick bodies were widely distributed beyond the usual distribution areas to the parietal cortices, occipital cortices, dentate nuclei, motor neuron nuclei in the brain stem, and spinal cord. The atypical clinical symptoms and the widespread neuropathological abnormalities observed in this case seem to represent an extremely extended form of PDPB.",

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AU - De Silva, Rohan

AU - Lees, Andrew

AU - Akiyama, Haruhiko

AU - Haga, Chie

AU - Ikeda, Kenji

AU - Kato, Motoichiro

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AU - Hara, Tsunekatsu

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Pick's disease with Pick bodies: An unusual autopsy case showing degeneration of the pontine nucleus, dentate nucleus, Clarke's column, and lower motor neuron

Abstract

Keywords

ASJC Scopus subject areas

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