Pick's disease with Pick bodies: An unusual autopsy case showing degeneration of the pontine nucleus, dentate nucleus, Clarke's column, and lower motor neuron

Tatsuro Oda, Kuniaki Tsuchiya, Tetsuaki Arai, Takashi Togo, Hirotake Uchikado, Rohan De Silva, Andrew Lees, Haruhiko Akiyama, Chie Haga, Kenji Ikeda, Motoichiro Kato, Yuji Kato, Tsunekatsu Hara, Mitsumoto Onaya, Koji Hori, Hiroshi Teramoto, Itaru Tominaga

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

We report a 51-year-old female with Pick's disease with Pick bodies (PDPB) showing a brainweight of 530 g. This case was considered to be a very rare case of PDPB, in which the lesion developed in the temporal and frontal lobes and later spread to the parietal lobe, occipital lobe, brainstem, cerebellum and spinal cord. This case showed very atypical clinicopathological findings. Clinically, bulging eyes and myoclonus were observed. Neuropathologically, Pick bodies were widely distributed beyond the usual distribution areas to the parietal cortices, occipital cortices, dentate nuclei, motor neuron nuclei in the brain stem, and spinal cord. The atypical clinical symptoms and the widespread neuropathological abnormalities observed in this case seem to represent an extremely extended form of PDPB.

Original languageEnglish
Pages (from-to)81-89
Number of pages9
JournalNeuropathology
Volume27
Issue number1
DOIs
Publication statusPublished - 2007 Feb

Fingerprint

Pick Disease of the Brain
Cerebellar Nuclei
Motor Neurons
Autopsy
Occipital Lobe
Parietal Lobe
Brain Stem
Spinal Cord
Myoclonus
Frontal Lobe
Temporal Lobe
Cerebellum
Spinal Cord Dorsal Horn

Keywords

  • Bulging eyes
  • Myoclonus
  • Pick body
  • Pick's disease
  • Tau
  • Topography

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neuroscience(all)

Cite this

Pick's disease with Pick bodies : An unusual autopsy case showing degeneration of the pontine nucleus, dentate nucleus, Clarke's column, and lower motor neuron. / Oda, Tatsuro; Tsuchiya, Kuniaki; Arai, Tetsuaki; Togo, Takashi; Uchikado, Hirotake; De Silva, Rohan; Lees, Andrew; Akiyama, Haruhiko; Haga, Chie; Ikeda, Kenji; Kato, Motoichiro; Kato, Yuji; Hara, Tsunekatsu; Onaya, Mitsumoto; Hori, Koji; Teramoto, Hiroshi; Tominaga, Itaru.

In: Neuropathology, Vol. 27, No. 1, 02.2007, p. 81-89.

Research output: Contribution to journalArticle

Oda, T, Tsuchiya, K, Arai, T, Togo, T, Uchikado, H, De Silva, R, Lees, A, Akiyama, H, Haga, C, Ikeda, K, Kato, M, Kato, Y, Hara, T, Onaya, M, Hori, K, Teramoto, H & Tominaga, I 2007, 'Pick's disease with Pick bodies: An unusual autopsy case showing degeneration of the pontine nucleus, dentate nucleus, Clarke's column, and lower motor neuron', Neuropathology, vol. 27, no. 1, pp. 81-89. https://doi.org/10.1111/j.1440-1789.2006.00744.x
Oda, Tatsuro ; Tsuchiya, Kuniaki ; Arai, Tetsuaki ; Togo, Takashi ; Uchikado, Hirotake ; De Silva, Rohan ; Lees, Andrew ; Akiyama, Haruhiko ; Haga, Chie ; Ikeda, Kenji ; Kato, Motoichiro ; Kato, Yuji ; Hara, Tsunekatsu ; Onaya, Mitsumoto ; Hori, Koji ; Teramoto, Hiroshi ; Tominaga, Itaru. / Pick's disease with Pick bodies : An unusual autopsy case showing degeneration of the pontine nucleus, dentate nucleus, Clarke's column, and lower motor neuron. In: Neuropathology. 2007 ; Vol. 27, No. 1. pp. 81-89.
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