Picrotoxin increased acetylcholine release from rat cultured embryonic septal neurons

Takeshi Suzuki, Ryoichi Takagi, Koichiro Kawashima

Research output: Contribution to journal › Article

3 Citations (Scopus)

Abstract

GABA is a major inhibitory neurotransmitter in the mature mammalian brain. In the early stages of brain development, it has been reported that GABA A receptor stimulation and the associated increase in Cl- conductance lead to membrane depolarization. In this study, we tested the effects of picrotoxin, a GABAA receptor Cl- channel blocker, on spontaneously released acetylcholine (ACh) from cultured rat embryonic septal cells. Picrotoxin increased spontaneously released ACh. These results indicate that blockade of GABA-activated Cl- channel increases neuronal excitability even in an early stage of the development.

Original languageEnglish
Pages (from-to)57-60
Number of pages4
JournalNeuroscience Letters
Volume356
Issue number1
DOIs
Publication statusPublished - 2004 Feb 6

Fingerprint

Picrotoxin
GABA-A Receptors
gamma-Aminobutyric Acid
Acetylcholine
Neurons
Brain
Neurotransmitter Agents
Membranes

Keywords

  • Acetylcholine
  • Chloride
  • Culture
  • GABA
  • Glutamic acid decarboxylase
  • Hippocampus
  • Septum

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Picrotoxin increased acetylcholine release from rat cultured embryonic septal neurons. / Suzuki, Takeshi; Takagi, Ryoichi; Kawashima, Koichiro.

In: Neuroscience Letters, Vol. 356, No. 1, 06.02.2004, p. 57-60.

Research output: Contribution to journal › Article

Suzuki, T, Takagi, R & Kawashima, K 2004, 'Picrotoxin increased acetylcholine release from rat cultured embryonic septal neurons', Neuroscience Letters, vol. 356, no. 1, pp. 57-60. https://doi.org/10.1016/j.neulet.2003.11.031
Suzuki T, Takagi R, Kawashima K. Picrotoxin increased acetylcholine release from rat cultured embryonic septal neurons. Neuroscience Letters. 2004 Feb 6;356(1):57-60. https://doi.org/10.1016/j.neulet.2003.11.031
Suzuki, Takeshi ; Takagi, Ryoichi ; Kawashima, Koichiro. / Picrotoxin increased acetylcholine release from rat cultured embryonic septal neurons. In: Neuroscience Letters. 2004 ; Vol. 356, No. 1. pp. 57-60.
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