Picrotoxin increased acetylcholine release from rat cultured embryonic septal neurons

Takeshi Suzuki, Ryoichi Takagi, Koichiro Kawashima

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

GABA is a major inhibitory neurotransmitter in the mature mammalian brain. In the early stages of brain development, it has been reported that GABA A receptor stimulation and the associated increase in Cl- conductance lead to membrane depolarization. In this study, we tested the effects of picrotoxin, a GABAA receptor Cl- channel blocker, on spontaneously released acetylcholine (ACh) from cultured rat embryonic septal cells. Picrotoxin increased spontaneously released ACh. These results indicate that blockade of GABA-activated Cl- channel increases neuronal excitability even in an early stage of the development.

Original languageEnglish
Pages (from-to)57-60
Number of pages4
JournalNeuroscience Letters
Volume356
Issue number1
DOIs
Publication statusPublished - 2004 Feb 6

Keywords

  • Acetylcholine
  • Chloride
  • Culture
  • GABA
  • Glutamic acid decarboxylase
  • Hippocampus
  • Septum

ASJC Scopus subject areas

  • Neuroscience(all)

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