Abstract
GABA is a major inhibitory neurotransmitter in the mature mammalian brain. In the early stages of brain development, it has been reported that GABA A receptor stimulation and the associated increase in Cl- conductance lead to membrane depolarization. In this study, we tested the effects of picrotoxin, a GABAA receptor Cl- channel blocker, on spontaneously released acetylcholine (ACh) from cultured rat embryonic septal cells. Picrotoxin increased spontaneously released ACh. These results indicate that blockade of GABA-activated Cl- channel increases neuronal excitability even in an early stage of the development.
Original language | English |
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Pages (from-to) | 57-60 |
Number of pages | 4 |
Journal | Neuroscience Letters |
Volume | 356 |
Issue number | 1 |
DOIs | |
Publication status | Published - 2004 Feb 6 |
Keywords
- Acetylcholine
- Chloride
- Culture
- GABA
- Glutamic acid decarboxylase
- Hippocampus
- Septum
ASJC Scopus subject areas
- Neuroscience(all)