Pinnamine, an alkaloidal marine toxin, isolated from Pinna muricata

N. Takada, M. Iwatsuki, K. Suenaga, D. Uemura

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

Pinnamine, a novel marine alkaloid, was isolated from the Okinawan bivalve Pinna muricata. Pinnamine was determined to be an alkaloid containing a dihydropyrone ring by spectroscopic analysis. The relative stereostructure of pinnamine was determined by an analysis of coupling constants and NOE experiments; the absolute stereostructure was determined by an analysis of the circular dichroism spectrum. Pinnamine exhibited significant acute toxicity against mice. (C) 2000 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)6425-6428
Number of pages4
JournalTetrahedron Letters
Volume41
Issue number33
DOIs
Publication statusPublished - 2000 Aug 12
Externally publishedYes

Keywords

  • Acute toxicity
  • Alkaloid
  • Dihydropyrone
  • Pinna muricata
  • Pinnamine
  • Structure determination

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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