Pinnamine, an alkaloidal marine toxin, isolated from Pinna muricata

N. Takada; M. Iwatsuki; K. Suenaga; D. Uemura

doi:10.1016/S0040-4039(00)00931-X

Pinnamine, an alkaloidal marine toxin, isolated from Pinna muricata

N. Takada, M. Iwatsuki, K. Suenaga, D. Uemura

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

Pinnamine, a novel marine alkaloid, was isolated from the Okinawan bivalve Pinna muricata. Pinnamine was determined to be an alkaloid containing a dihydropyrone ring by spectroscopic analysis. The relative stereostructure of pinnamine was determined by an analysis of coupling constants and NOE experiments; the absolute stereostructure was determined by an analysis of the circular dichroism spectrum. Pinnamine exhibited significant acute toxicity against mice. (C) 2000 Elsevier Science Ltd.

Original language	English
Pages (from-to)	6425-6428
Number of pages	4
Journal	Tetrahedron Letters
Volume	41
Issue number	33
DOIs	https://doi.org/10.1016/S0040-4039(00)00931-X
Publication status	Published - 2000 Aug 12
Externally published	Yes

Keywords

Acute toxicity
Alkaloid
Dihydropyrone
Pinna muricata
Pinnamine
Structure determination

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/S0040-4039(00)00931-X

Cite this

@article{64651b1a8ea84eb2a3654d1cb6579da8,

title = "Pinnamine, an alkaloidal marine toxin, isolated from Pinna muricata",

abstract = "Pinnamine, a novel marine alkaloid, was isolated from the Okinawan bivalve Pinna muricata. Pinnamine was determined to be an alkaloid containing a dihydropyrone ring by spectroscopic analysis. The relative stereostructure of pinnamine was determined by an analysis of coupling constants and NOE experiments; the absolute stereostructure was determined by an analysis of the circular dichroism spectrum. Pinnamine exhibited significant acute toxicity against mice. (C) 2000 Elsevier Science Ltd.",

keywords = "Acute toxicity, Alkaloid, Dihydropyrone, Pinna muricata, Pinnamine, Structure determination",

author = "N. Takada and M. Iwatsuki and K. Suenaga and D. Uemura",

note = "Funding Information: This work was supported in part by Grants-in-Aid for Scientific Research and Scientific Research on Priority Areas {\textquoteleft}Targeted Pursuit of Challenging Bioactive Molecules{\textquoteright} from the Ministry of Education, Science, Sports, and Culture, Japan. We are indebted to Wako Pure Chemical Industries Ltd, and Banyu Pharmaceutical Co., Ltd for their financial support. We thank Professors R. Noyori and M. Kitamura (COE, Nagoya University) for performing the NMR experiments.",

year = "2000",

month = aug,

day = "12",

doi = "10.1016/S0040-4039(00)00931-X",

language = "English",

volume = "41",

pages = "6425--6428",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Limited",

number = "33",

}

TY - JOUR

T1 - Pinnamine, an alkaloidal marine toxin, isolated from Pinna muricata

AU - Takada, N.

AU - Iwatsuki, M.

AU - Suenaga, K.

AU - Uemura, D.

N1 - Funding Information: This work was supported in part by Grants-in-Aid for Scientific Research and Scientific Research on Priority Areas ‘Targeted Pursuit of Challenging Bioactive Molecules’ from the Ministry of Education, Science, Sports, and Culture, Japan. We are indebted to Wako Pure Chemical Industries Ltd, and Banyu Pharmaceutical Co., Ltd for their financial support. We thank Professors R. Noyori and M. Kitamura (COE, Nagoya University) for performing the NMR experiments.

PY - 2000/8/12

Y1 - 2000/8/12

N2 - Pinnamine, a novel marine alkaloid, was isolated from the Okinawan bivalve Pinna muricata. Pinnamine was determined to be an alkaloid containing a dihydropyrone ring by spectroscopic analysis. The relative stereostructure of pinnamine was determined by an analysis of coupling constants and NOE experiments; the absolute stereostructure was determined by an analysis of the circular dichroism spectrum. Pinnamine exhibited significant acute toxicity against mice. (C) 2000 Elsevier Science Ltd.

AB - Pinnamine, a novel marine alkaloid, was isolated from the Okinawan bivalve Pinna muricata. Pinnamine was determined to be an alkaloid containing a dihydropyrone ring by spectroscopic analysis. The relative stereostructure of pinnamine was determined by an analysis of coupling constants and NOE experiments; the absolute stereostructure was determined by an analysis of the circular dichroism spectrum. Pinnamine exhibited significant acute toxicity against mice. (C) 2000 Elsevier Science Ltd.

KW - Acute toxicity

KW - Alkaloid

KW - Dihydropyrone

KW - Pinna muricata

KW - Pinnamine

KW - Structure determination

UR - http://www.scopus.com/inward/record.url?scp=0034641489&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034641489&partnerID=8YFLogxK

U2 - 10.1016/S0040-4039(00)00931-X

DO - 10.1016/S0040-4039(00)00931-X

M3 - Article

AN - SCOPUS:0034641489

SN - 0040-4039

VL - 41

SP - 6425

EP - 6428

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 33

ER -

Pinnamine, an alkaloidal marine toxin, isolated from Pinna muricata

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this