Abstract
Pinnatoxins B and C, the most toxic components in the pinnatoxin series, were successfully purified from the Okinawan bivalve Pinna muricata. Their gross structures were determined based on NMR and MS/MS spectral analyses. Their stereostructures were mainly determined by transformation reactions. Pinnatoxins B and C, C-34 epimers of each other, have an amphoteric macrocycle composed of 6,7-spiro, 5,6-bicyclo and 6,5,6-trispiro ketal rings, the same as in pinnatoxins A and D.
| Original language | English |
|---|---|
| Pages (from-to) | 3491-3494 |
| Number of pages | 4 |
| Journal | Tetrahedron Letters |
| Volume | 42 |
| Issue number | 20 |
| DOIs | |
| Publication status | Published - 2001 May 14 |
| Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry
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Takada, N., Umemura, N., Suenaga, K., Chou, T., Nagatsu, A., Haino, T., Yamada, K., & Uemura, D. (2001). Pinnatoxins B and C, the most toxic components in the pinnatoxin series from the Okinawan bivalve Pinna muricata. Tetrahedron Letters, 42(20), 3491-3494. https://doi.org/10.1016/S0040-4039(01)00480-4