Abstract
Pinnatoxins B and C, the most toxic components in the pinnatoxin series, were successfully purified from the Okinawan bivalve Pinna muricata. Their gross structures were determined based on NMR and MS/MS spectral analyses. Their stereostructures were mainly determined by transformation reactions. Pinnatoxins B and C, C-34 epimers of each other, have an amphoteric macrocycle composed of 6,7-spiro, 5,6-bicyclo and 6,5,6-trispiro ketal rings, the same as in pinnatoxins A and D.
| Original language | English |
|---|---|
| Pages (from-to) | 3491-3494 |
| Number of pages | 4 |
| Journal | Tetrahedron Letters |
| Volume | 42 |
| Issue number | 20 |
| DOIs | |
| Publication status | Published - 2001 May 14 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Biochemistry
- Organic Chemistry
- Drug Discovery
Cite this
Pinnatoxins B and C, the most toxic components in the pinnatoxin series from the Okinawan bivalve Pinna muricata. / Takada, Noboru; Umemura, Naoyoshi; Suenaga, Kiyotake; Chou, Tong; Nagatsu, Akito; Haino, Takeharu; Yamada, Kaoru; Uemura, Daisuke.
In: Tetrahedron Letters, Vol. 42, No. 20, 14.05.2001, p. 3491-3494.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Pinnatoxins B and C, the most toxic components in the pinnatoxin series from the Okinawan bivalve Pinna muricata
AU - Takada, Noboru
AU - Umemura, Naoyoshi
AU - Suenaga, Kiyotake
AU - Chou, Tong
AU - Nagatsu, Akito
AU - Haino, Takeharu
AU - Yamada, Kaoru
AU - Uemura, Daisuke
PY - 2001/5/14
Y1 - 2001/5/14
N2 - Pinnatoxins B and C, the most toxic components in the pinnatoxin series, were successfully purified from the Okinawan bivalve Pinna muricata. Their gross structures were determined based on NMR and MS/MS spectral analyses. Their stereostructures were mainly determined by transformation reactions. Pinnatoxins B and C, C-34 epimers of each other, have an amphoteric macrocycle composed of 6,7-spiro, 5,6-bicyclo and 6,5,6-trispiro ketal rings, the same as in pinnatoxins A and D.
AB - Pinnatoxins B and C, the most toxic components in the pinnatoxin series, were successfully purified from the Okinawan bivalve Pinna muricata. Their gross structures were determined based on NMR and MS/MS spectral analyses. Their stereostructures were mainly determined by transformation reactions. Pinnatoxins B and C, C-34 epimers of each other, have an amphoteric macrocycle composed of 6,7-spiro, 5,6-bicyclo and 6,5,6-trispiro ketal rings, the same as in pinnatoxins A and D.
UR - http://www.scopus.com/inward/record.url?scp=0035858744&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035858744&partnerID=8YFLogxK
U2 - 10.1016/S0040-4039(01)00480-4
DO - 10.1016/S0040-4039(01)00480-4
M3 - Article
AN - SCOPUS:0035858744
VL - 42
SP - 3491
EP - 3494
JO - Tetrahedron Letters
JF - Tetrahedron Letters
SN - 0040-4039
IS - 20
ER -