Pinnatoxins B and C, the most toxic components in the pinnatoxin series from the Okinawan bivalve Pinna muricata

Noboru Takada; Naoyoshi Umemura; Kiyotake Suenaga; Tong Chou; Akito Nagatsu; Takeharu Haino; Kaoru Yamada; Daisuke Uemura

doi:10.1016/S0040-4039(01)00480-4

Pinnatoxins B and C, the most toxic components in the pinnatoxin series from the Okinawan bivalve Pinna muricata

Noboru Takada, Naoyoshi Umemura, Kiyotake Suenaga, Tong Chou, Akito Nagatsu, Takeharu Haino, Kaoru Yamada, Daisuke Uemura

Research output: Contribution to journal › Article

100 Citations (Scopus)

Abstract

Pinnatoxins B and C, the most toxic components in the pinnatoxin series, were successfully purified from the Okinawan bivalve Pinna muricata. Their gross structures were determined based on NMR and MS/MS spectral analyses. Their stereostructures were mainly determined by transformation reactions. Pinnatoxins B and C, C-34 epimers of each other, have an amphoteric macrocycle composed of 6,7-spiro, 5,6-bicyclo and 6,5,6-trispiro ketal rings, the same as in pinnatoxins A and D.

Original language	English
Pages (from-to)	3491-3494
Number of pages	4
Journal	Tetrahedron Letters
Volume	42
Issue number	20
DOIs	https://doi.org/10.1016/S0040-4039(01)00480-4
Publication status	Published - 2001 May 14
Externally published	Yes

Fingerprint

ASJC Scopus subject areas

Biochemistry
Organic Chemistry
Drug Discovery

Cite this

Takada, N., Umemura, N., Suenaga, K., Chou, T., Nagatsu, A., Haino, T., Yamada, K., & Uemura, D. (2001). Pinnatoxins B and C, the most toxic components in the pinnatoxin series from the Okinawan bivalve Pinna muricata. Tetrahedron Letters, 42(20), 3491-3494. https://doi.org/10.1016/S0040-4039(01)00480-4

@article{d5f39bf57f5242259d62df5bfdd18646,

title = "Pinnatoxins B and C, the most toxic components in the pinnatoxin series from the Okinawan bivalve Pinna muricata",

abstract = "Pinnatoxins B and C, the most toxic components in the pinnatoxin series, were successfully purified from the Okinawan bivalve Pinna muricata. Their gross structures were determined based on NMR and MS/MS spectral analyses. Their stereostructures were mainly determined by transformation reactions. Pinnatoxins B and C, C-34 epimers of each other, have an amphoteric macrocycle composed of 6,7-spiro, 5,6-bicyclo and 6,5,6-trispiro ketal rings, the same as in pinnatoxins A and D.",

author = "Noboru Takada and Naoyoshi Umemura and Kiyotake Suenaga and Tong Chou and Akito Nagatsu and Takeharu Haino and Kaoru Yamada and Daisuke Uemura",

year = "2001",

month = may

day = "14",

doi = "10.1016/S0040-4039(01)00480-4",

language = "English",

volume = "42",

pages = "3491--3494",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Limited",

number = "20",

}

TY - JOUR

T1 - Pinnatoxins B and C, the most toxic components in the pinnatoxin series from the Okinawan bivalve Pinna muricata

AU - Takada, Noboru

AU - Umemura, Naoyoshi

AU - Suenaga, Kiyotake

AU - Chou, Tong

AU - Nagatsu, Akito

AU - Haino, Takeharu

AU - Yamada, Kaoru

AU - Uemura, Daisuke

PY - 2001/5/14

Y1 - 2001/5/14

N2 - Pinnatoxins B and C, the most toxic components in the pinnatoxin series, were successfully purified from the Okinawan bivalve Pinna muricata. Their gross structures were determined based on NMR and MS/MS spectral analyses. Their stereostructures were mainly determined by transformation reactions. Pinnatoxins B and C, C-34 epimers of each other, have an amphoteric macrocycle composed of 6,7-spiro, 5,6-bicyclo and 6,5,6-trispiro ketal rings, the same as in pinnatoxins A and D.

AB - Pinnatoxins B and C, the most toxic components in the pinnatoxin series, were successfully purified from the Okinawan bivalve Pinna muricata. Their gross structures were determined based on NMR and MS/MS spectral analyses. Their stereostructures were mainly determined by transformation reactions. Pinnatoxins B and C, C-34 epimers of each other, have an amphoteric macrocycle composed of 6,7-spiro, 5,6-bicyclo and 6,5,6-trispiro ketal rings, the same as in pinnatoxins A and D.

UR - http://www.scopus.com/inward/record.url?scp=0035858744&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035858744&partnerID=8YFLogxK

U2 - 10.1016/S0040-4039(01)00480-4

DO - 10.1016/S0040-4039(01)00480-4

M3 - Article

AN - SCOPUS:0035858744

VL - 42

SP - 3491

EP - 3494

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 20

ER -

Access to Document

10.1016/S0040-4039(01)00480-4