TY - JOUR
T1 - Pinnatoxins B and C, the most toxic components in the pinnatoxin series from the Okinawan bivalve Pinna muricata
AU - Takada, Noboru
AU - Umemura, Naoyoshi
AU - Suenaga, Kiyotake
AU - Chou, Tong
AU - Nagatsu, Akito
AU - Haino, Takeharu
AU - Yamada, Kaoru
AU - Uemura, Daisuke
N1 - Funding Information:
This work was supported in part by Grants-in-Aid for Scientific Research (No. 11558079) and Scientific Research on Priority Areas (A) (No. 12045235) from the Ministry of Education, Culture, Sports, Science and Technology, Japan. We are indebted to Wako Pure Chemical Industries Ltd., and Banyu Pharmaceutical Co., Ltd. for their financial support. We thank Professors R. Noyori and M. Kitamura (COE, Nagoya University) for performing the NMR experiments.
PY - 2001/5/14
Y1 - 2001/5/14
N2 - Pinnatoxins B and C, the most toxic components in the pinnatoxin series, were successfully purified from the Okinawan bivalve Pinna muricata. Their gross structures were determined based on NMR and MS/MS spectral analyses. Their stereostructures were mainly determined by transformation reactions. Pinnatoxins B and C, C-34 epimers of each other, have an amphoteric macrocycle composed of 6,7-spiro, 5,6-bicyclo and 6,5,6-trispiro ketal rings, the same as in pinnatoxins A and D.
AB - Pinnatoxins B and C, the most toxic components in the pinnatoxin series, were successfully purified from the Okinawan bivalve Pinna muricata. Their gross structures were determined based on NMR and MS/MS spectral analyses. Their stereostructures were mainly determined by transformation reactions. Pinnatoxins B and C, C-34 epimers of each other, have an amphoteric macrocycle composed of 6,7-spiro, 5,6-bicyclo and 6,5,6-trispiro ketal rings, the same as in pinnatoxins A and D.
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U2 - 10.1016/S0040-4039(01)00480-4
DO - 10.1016/S0040-4039(01)00480-4
M3 - Article
AN - SCOPUS:0035858744
VL - 42
SP - 3491
EP - 3494
JO - Tetrahedron Letters
JF - Tetrahedron Letters
SN - 0040-4039
IS - 20
ER -