Pirin regulates epithelial to mesenchymal transition independently of Bcl3-Slug signaling

Kuniya Komai, Yuki Niwa, Yukiko Sasazawa, Siro Simizu

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Epithelial to mesenchymal transition (EMT) is an important mechanism for the initial step of metastasis. Proteomic analysis indicates that Pirin is involved in metastasis. However, there are no reports demonstrating its direct contribution. Here we investigated the involvement of Pirin in EMT. In HeLa cells, Pirin suppressed E-cadherin expression and regulated the expression of other EMT markers. Furthermore, cells expressing Pirin exhibited a spindle-like morphology, which is reminiscent of EMT. A Pirin mutant defective for Bcl3 binding decreased E-cadherin expression similar to wild-type, suggesting that Pirin regulates E-cadherin independently of Bcl3-Slug signaling. These data provide direct evidence that Pirin contributes to cancer metastasis.

Original languageEnglish
Pages (from-to)738-743
Number of pages6
JournalFEBS Letters
Volume589
Issue number6
DOIs
Publication statusPublished - 2015 Mar 12

Keywords

  • E-cadherin
  • Epithelial to mesenchymal transition
  • Metastasis
  • Morphological change
  • Pirin

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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