Pivotal roles of T-helper 17-related cytokines, IL-17, IL-22, and IL-23, in inflammatory diseases

Ning Qu, Mingli Xu, Izuru Mizoguchi, Jun Ichi Furusawa, Kotaro Kaneko, Kazunori Watanabe, Junichiro Mizuguchi, Masahiro Itoh, Yutaka Kawakami, Takayuki Yoshimoto

Research output: Contribution to journalReview article

104 Citations (Scopus)

Abstract

T-helper 17 (Th17) cells are characterized by producing interleukin-17 (IL-17, also called IL-17A), IL-17F, IL-21, and IL-22 and potentially TNF-α and IL-6 upon certain stimulation. IL-23, which promotes Th17 cell development, as well as IL-17 and IL-22 produced by the Th17 cells plays essential roles in various inflammatory diseases, such as experimental autoimmune encephalomyelitis, rheumatoid arthritis, colitis, and Concanavalin A-induced hepatitis. In this review, we summarize the characteristics of the functional role of Th17 cells, with particular focus on the Th17 cell-related cytokines such as IL-17, IL-22, and IL-23, in mouse models and human inflammatory diseases.

Original languageEnglish
Article number968549
JournalClinical and Developmental Immunology
Volume2013
DOIs
Publication statusPublished - 2013
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Qu, N., Xu, M., Mizoguchi, I., Furusawa, J. I., Kaneko, K., Watanabe, K., Mizuguchi, J., Itoh, M., Kawakami, Y., & Yoshimoto, T. (2013). Pivotal roles of T-helper 17-related cytokines, IL-17, IL-22, and IL-23, in inflammatory diseases. Clinical and Developmental Immunology, 2013, [968549]. https://doi.org/10.1155/2013/968549