Pivotal roles of T-helper 17-related cytokines, IL-17, IL-22, and IL-23, in inflammatory diseases

Ning Qu, Mingli Xu, Izuru Mizoguchi, Jun Ichi Furusawa, Kotaro Kaneko, Kazunori Watanabe, Junichiro Mizuguchi, Masahiro Itoh, Yutaka Kawakami, Takayuki Yoshimoto

Research output: Contribution to journalArticle

97 Citations (Scopus)

Abstract

T-helper 17 (Th17) cells are characterized by producing interleukin-17 (IL-17, also called IL-17A), IL-17F, IL-21, and IL-22 and potentially TNF-α and IL-6 upon certain stimulation. IL-23, which promotes Th17 cell development, as well as IL-17 and IL-22 produced by the Th17 cells plays essential roles in various inflammatory diseases, such as experimental autoimmune encephalomyelitis, rheumatoid arthritis, colitis, and Concanavalin A-induced hepatitis. In this review, we summarize the characteristics of the functional role of Th17 cells, with particular focus on the Th17 cell-related cytokines such as IL-17, IL-22, and IL-23, in mouse models and human inflammatory diseases.

Original languageEnglish
Article number968549
JournalClinical and Developmental Immunology
Volume2013
DOIs
Publication statusPublished - 2013

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Interleukin-23
Interleukin-17
Th17 Cells
Cytokines
Autoimmune Experimental Encephalomyelitis
Colitis
Concanavalin A
Hepatitis
interleukin-22
Interleukin-6
Rheumatoid Arthritis

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Medicine(all)

Cite this

Qu, N., Xu, M., Mizoguchi, I., Furusawa, J. I., Kaneko, K., Watanabe, K., ... Yoshimoto, T. (2013). Pivotal roles of T-helper 17-related cytokines, IL-17, IL-22, and IL-23, in inflammatory diseases. Clinical and Developmental Immunology, 2013, [968549]. https://doi.org/10.1155/2013/968549

Pivotal roles of T-helper 17-related cytokines, IL-17, IL-22, and IL-23, in inflammatory diseases. / Qu, Ning; Xu, Mingli; Mizoguchi, Izuru; Furusawa, Jun Ichi; Kaneko, Kotaro; Watanabe, Kazunori; Mizuguchi, Junichiro; Itoh, Masahiro; Kawakami, Yutaka; Yoshimoto, Takayuki.

In: Clinical and Developmental Immunology, Vol. 2013, 968549, 2013.

Research output: Contribution to journalArticle

Qu, N, Xu, M, Mizoguchi, I, Furusawa, JI, Kaneko, K, Watanabe, K, Mizuguchi, J, Itoh, M, Kawakami, Y & Yoshimoto, T 2013, 'Pivotal roles of T-helper 17-related cytokines, IL-17, IL-22, and IL-23, in inflammatory diseases', Clinical and Developmental Immunology, vol. 2013, 968549. https://doi.org/10.1155/2013/968549
Qu, Ning ; Xu, Mingli ; Mizoguchi, Izuru ; Furusawa, Jun Ichi ; Kaneko, Kotaro ; Watanabe, Kazunori ; Mizuguchi, Junichiro ; Itoh, Masahiro ; Kawakami, Yutaka ; Yoshimoto, Takayuki. / Pivotal roles of T-helper 17-related cytokines, IL-17, IL-22, and IL-23, in inflammatory diseases. In: Clinical and Developmental Immunology. 2013 ; Vol. 2013.
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