PK-PD analysis of tebipenem pivoxil in clinical trials for pediatric patients

Kyoichi Totsuka; Kazumasa Aizawa; Jun Morita; Seiji Hori; Satoshi Iwata; Keisuke Sunakawa

PK-PD analysis of tebipenem pivoxil in clinical trials for pediatric patients

Kyoichi Totsuka, Kazumasa Aizawa, Jun Morita, Seiji Hori, Satoshi Iwata, Keisuke Sunakawa

Department of Infectious Diseases

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

We conducted PK-PD analysis of tebipenern pivoxil(TBPM-PI), an oral carbapenem antibiotic and TBPM prodrug, in clinical studies of pediatric patients. We analyzed 86 strains isolated from 70 subjects whose plasma TBPM concentration and the MIC of causative organisms had been measured. We studied the target PK-PD parameter based on the relationship between PK-PD parameters and bacteriological or clinical efficacy. Eradication was high, with only one strain persisting. The presumed target of AUCf/MIC was 6. We did not find a clear relationship between C_maxf/MIC or T>MIC and bacteriological efficacy. We investigated PK-PD analysis of TBPM-PI in clinical study for pediatric patients. And we calculated the presumed target PK-PD parameter at which TBPM-PI was expected to show the efficacy. This is very useful in using TBPM-PI appropriately.

Original language	English
Pages (from-to)	186-191
Number of pages	6
Journal	Japanese Journal of Chemotherapy
Volume	57
Issue number	SUPPL. 1
Publication status	Published - 2009 Mar

Keywords

Child
PK-P
Tebipenem pivoxil

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)

Cite this

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title = "PK-PD analysis of tebipenem pivoxil in clinical trials for pediatric patients",

abstract = "We conducted PK-PD analysis of tebipenern pivoxil(TBPM-PI), an oral carbapenem antibiotic and TBPM prodrug, in clinical studies of pediatric patients. We analyzed 86 strains isolated from 70 subjects whose plasma TBPM concentration and the MIC of causative organisms had been measured. We studied the target PK-PD parameter based on the relationship between PK-PD parameters and bacteriological or clinical efficacy. Eradication was high, with only one strain persisting. The presumed target of AUCf/MIC was 6. We did not find a clear relationship between Cmaxf/MIC or T>MIC and bacteriological efficacy. We investigated PK-PD analysis of TBPM-PI in clinical study for pediatric patients. And we calculated the presumed target PK-PD parameter at which TBPM-PI was expected to show the efficacy. This is very useful in using TBPM-PI appropriately.",

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T1 - PK-PD analysis of tebipenem pivoxil in clinical trials for pediatric patients

AU - Totsuka, Kyoichi

AU - Aizawa, Kazumasa

AU - Morita, Jun

AU - Hori, Seiji

AU - Iwata, Satoshi

AU - Sunakawa, Keisuke

PY - 2009/3

Y1 - 2009/3

N2 - We conducted PK-PD analysis of tebipenern pivoxil(TBPM-PI), an oral carbapenem antibiotic and TBPM prodrug, in clinical studies of pediatric patients. We analyzed 86 strains isolated from 70 subjects whose plasma TBPM concentration and the MIC of causative organisms had been measured. We studied the target PK-PD parameter based on the relationship between PK-PD parameters and bacteriological or clinical efficacy. Eradication was high, with only one strain persisting. The presumed target of AUCf/MIC was 6. We did not find a clear relationship between Cmaxf/MIC or T>MIC and bacteriological efficacy. We investigated PK-PD analysis of TBPM-PI in clinical study for pediatric patients. And we calculated the presumed target PK-PD parameter at which TBPM-PI was expected to show the efficacy. This is very useful in using TBPM-PI appropriately.

AB - We conducted PK-PD analysis of tebipenern pivoxil(TBPM-PI), an oral carbapenem antibiotic and TBPM prodrug, in clinical studies of pediatric patients. We analyzed 86 strains isolated from 70 subjects whose plasma TBPM concentration and the MIC of causative organisms had been measured. We studied the target PK-PD parameter based on the relationship between PK-PD parameters and bacteriological or clinical efficacy. Eradication was high, with only one strain persisting. The presumed target of AUCf/MIC was 6. We did not find a clear relationship between Cmaxf/MIC or T>MIC and bacteriological efficacy. We investigated PK-PD analysis of TBPM-PI in clinical study for pediatric patients. And we calculated the presumed target PK-PD parameter at which TBPM-PI was expected to show the efficacy. This is very useful in using TBPM-PI appropriately.

KW - Child

KW - PK-P

KW - Tebipenem pivoxil

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ER -

PK-PD analysis of tebipenem pivoxil in clinical trials for pediatric patients

Abstract

Keywords

ASJC Scopus subject areas

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