PK-PD analysis of tebipenem pivoxil in clinical trials for pediatric patients

Kyoichi Totsuka, Kazumasa Aizawa, Jun Morita, Seiji Hori, Satoshi Iwata, Keisuke Sunakawa

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

We conducted PK-PD analysis of tebipenern pivoxil(TBPM-PI), an oral carbapenem antibiotic and TBPM prodrug, in clinical studies of pediatric patients. We analyzed 86 strains isolated from 70 subjects whose plasma TBPM concentration and the MIC of causative organisms had been measured. We studied the target PK-PD parameter based on the relationship between PK-PD parameters and bacteriological or clinical efficacy. Eradication was high, with only one strain persisting. The presumed target of AUCf/MIC was 6. We did not find a clear relationship between Cmaxf/MIC or T>MIC and bacteriological efficacy. We investigated PK-PD analysis of TBPM-PI in clinical study for pediatric patients. And we calculated the presumed target PK-PD parameter at which TBPM-PI was expected to show the efficacy. This is very useful in using TBPM-PI appropriately.

Original languageEnglish
Pages (from-to)186-191
Number of pages6
JournalJapanese Journal of Chemotherapy
Volume57
Issue numberSUPPL. 1
Publication statusPublished - 2009 Mar
Externally publishedYes

Fingerprint

Clinical Trials
Pediatrics
Carbapenems
Prodrugs
Clinical Studies
tebipenem

Keywords

  • Child
  • PK-P
  • Tebipenem pivoxil

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

Cite this

Totsuka, K., Aizawa, K., Morita, J., Hori, S., Iwata, S., & Sunakawa, K. (2009). PK-PD analysis of tebipenem pivoxil in clinical trials for pediatric patients. Japanese Journal of Chemotherapy, 57(SUPPL. 1), 186-191.

PK-PD analysis of tebipenem pivoxil in clinical trials for pediatric patients. / Totsuka, Kyoichi; Aizawa, Kazumasa; Morita, Jun; Hori, Seiji; Iwata, Satoshi; Sunakawa, Keisuke.

In: Japanese Journal of Chemotherapy, Vol. 57, No. SUPPL. 1, 03.2009, p. 186-191.

Research output: Contribution to journalArticle

Totsuka, K, Aizawa, K, Morita, J, Hori, S, Iwata, S & Sunakawa, K 2009, 'PK-PD analysis of tebipenem pivoxil in clinical trials for pediatric patients', Japanese Journal of Chemotherapy, vol. 57, no. SUPPL. 1, pp. 186-191.
Totsuka K, Aizawa K, Morita J, Hori S, Iwata S, Sunakawa K. PK-PD analysis of tebipenem pivoxil in clinical trials for pediatric patients. Japanese Journal of Chemotherapy. 2009 Mar;57(SUPPL. 1):186-191.
Totsuka, Kyoichi ; Aizawa, Kazumasa ; Morita, Jun ; Hori, Seiji ; Iwata, Satoshi ; Sunakawa, Keisuke. / PK-PD analysis of tebipenem pivoxil in clinical trials for pediatric patients. In: Japanese Journal of Chemotherapy. 2009 ; Vol. 57, No. SUPPL. 1. pp. 186-191.
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