We conducted PK-PD analysis of tebipenern pivoxil(TBPM-PI), an oral carbapenem antibiotic and TBPM prodrug, in clinical studies of pediatric patients. We analyzed 86 strains isolated from 70 subjects whose plasma TBPM concentration and the MIC of causative organisms had been measured. We studied the target PK-PD parameter based on the relationship between PK-PD parameters and bacteriological or clinical efficacy. Eradication was high, with only one strain persisting. The presumed target of AUCf/MIC was 6. We did not find a clear relationship between Cmaxf/MIC or T>MIC and bacteriological efficacy. We investigated PK-PD analysis of TBPM-PI in clinical study for pediatric patients. And we calculated the presumed target PK-PD parameter at which TBPM-PI was expected to show the efficacy. This is very useful in using TBPM-PI appropriately.
|Number of pages||6|
|Journal||Japanese Journal of Chemotherapy|
|Issue number||SUPPL. 1|
|Publication status||Published - 2009 Mar|
- Tebipenem pivoxil
ASJC Scopus subject areas
- Pharmacology (medical)