Placental (pro)renin receptor expression and plasma soluble (pro)renin receptor levels in preeclampsia

Tatsuya Nartita, Atsuhiro Ichihara, Kikumi Matsuoka, Yasushi Takai, Kanako Bokuda, Satoshi Morimoto, Hiroshi Itoh, Hiroyuki Seki

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Introduction The prorenin receptor ((P)RR) contributes to the regulation of the tissue renin-angiotensin system (RAS) and the function of V-ATPase, which are essential for Wnt signaling. Thus, (P)RRs may be involved in the control both of feto-placental and maternal circulation during pregnancy. This study was conducted to clarify how placental (P)RR expression and plasma soluble (P)RR [s(P)RR] levels are associated with blood pressure elevations and renal function during pregnancy. Methods We conducted a cross-sectional study, conducted at Saitama medical center in 2010-2013. Preeclamptic women (n = 16) diagnosed according to the criteria of Japan Society of Obstetrics and Gynecology and normotensive pregnant women (n = 15) participated in the study. We measured the expression of (P)RR in the placenta, plasma s(P)RR levels, systolic blood pressure (SBP), and estimated glomerular filtration rate (EGFR). Results Placental expression of (P)RR was significantly higher in preeclamptic women than in normotensive pregnant women. The plasma s(P)RR levels were significantly higher in preeclamptic women than in normotensive pregnant women. Systolic blood pressure (SBP) was positively correlated with placental (P)RR levels (P = 0.0001) and plasma s(P)RR levels (P = 0.005) in all pregnant women. In preeclamptic women, SBP was positively correlated with placental (P)RR levels (P = 0.004), but not with plasma s(P)RR levels (P = 0.15). The EGFR was negatively correlated with placental (P)RR levels (P = 0.02) and plasma s(P)RR levels (P = 0.0002) in all pregnant women. In preeclamptic women, EGFR was negatively correlated with plasma s(P)RR levels (P = 0.006), but not with placental (P)RR levels (P = 0.93). Discussion Placental (P)RR can be involved in blood pressure regulation via the tissue RAS. On the other hand, plasma s(P)RR may be involved in the pathogenesis of decreased renal function in preeclampsia.

Original languageEnglish
Pages (from-to)72-78
Number of pages7
JournalPlacenta
Volume37
DOIs
Publication statusPublished - 2016 Jan 1

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Pre-Eclampsia
Renin
Blood Pressure
Pregnant Women
Glomerular Filtration Rate
Renin-Angiotensin System
Placental Circulation
Kidney
Pregnancy
Gynecology
Placenta
Obstetrics
Adenosine Triphosphatases
Japan
Cross-Sectional Studies
Mothers

Keywords

  • Preeclampsia
  • Renin-angiotensin system (RAS)
  • Soluble (pro)renin receptor

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine
  • Developmental Biology

Cite this

Nartita, T., Ichihara, A., Matsuoka, K., Takai, Y., Bokuda, K., Morimoto, S., ... Seki, H. (2016). Placental (pro)renin receptor expression and plasma soluble (pro)renin receptor levels in preeclampsia. Placenta, 37, 72-78. https://doi.org/10.1016/j.placenta.2015.11.007

Placental (pro)renin receptor expression and plasma soluble (pro)renin receptor levels in preeclampsia. / Nartita, Tatsuya; Ichihara, Atsuhiro; Matsuoka, Kikumi; Takai, Yasushi; Bokuda, Kanako; Morimoto, Satoshi; Itoh, Hiroshi; Seki, Hiroyuki.

In: Placenta, Vol. 37, 01.01.2016, p. 72-78.

Research output: Contribution to journalArticle

Nartita, T, Ichihara, A, Matsuoka, K, Takai, Y, Bokuda, K, Morimoto, S, Itoh, H & Seki, H 2016, 'Placental (pro)renin receptor expression and plasma soluble (pro)renin receptor levels in preeclampsia', Placenta, vol. 37, pp. 72-78. https://doi.org/10.1016/j.placenta.2015.11.007
Nartita, Tatsuya ; Ichihara, Atsuhiro ; Matsuoka, Kikumi ; Takai, Yasushi ; Bokuda, Kanako ; Morimoto, Satoshi ; Itoh, Hiroshi ; Seki, Hiroyuki. / Placental (pro)renin receptor expression and plasma soluble (pro)renin receptor levels in preeclampsia. In: Placenta. 2016 ; Vol. 37. pp. 72-78.
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AU - Matsuoka, Kikumi

AU - Takai, Yasushi

AU - Bokuda, Kanako

AU - Morimoto, Satoshi

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AU - Seki, Hiroyuki

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N2 - Introduction The prorenin receptor ((P)RR) contributes to the regulation of the tissue renin-angiotensin system (RAS) and the function of V-ATPase, which are essential for Wnt signaling. Thus, (P)RRs may be involved in the control both of feto-placental and maternal circulation during pregnancy. This study was conducted to clarify how placental (P)RR expression and plasma soluble (P)RR [s(P)RR] levels are associated with blood pressure elevations and renal function during pregnancy. Methods We conducted a cross-sectional study, conducted at Saitama medical center in 2010-2013. Preeclamptic women (n = 16) diagnosed according to the criteria of Japan Society of Obstetrics and Gynecology and normotensive pregnant women (n = 15) participated in the study. We measured the expression of (P)RR in the placenta, plasma s(P)RR levels, systolic blood pressure (SBP), and estimated glomerular filtration rate (EGFR). Results Placental expression of (P)RR was significantly higher in preeclamptic women than in normotensive pregnant women. The plasma s(P)RR levels were significantly higher in preeclamptic women than in normotensive pregnant women. Systolic blood pressure (SBP) was positively correlated with placental (P)RR levels (P = 0.0001) and plasma s(P)RR levels (P = 0.005) in all pregnant women. In preeclamptic women, SBP was positively correlated with placental (P)RR levels (P = 0.004), but not with plasma s(P)RR levels (P = 0.15). The EGFR was negatively correlated with placental (P)RR levels (P = 0.02) and plasma s(P)RR levels (P = 0.0002) in all pregnant women. In preeclamptic women, EGFR was negatively correlated with plasma s(P)RR levels (P = 0.006), but not with placental (P)RR levels (P = 0.93). Discussion Placental (P)RR can be involved in blood pressure regulation via the tissue RAS. On the other hand, plasma s(P)RR may be involved in the pathogenesis of decreased renal function in preeclampsia.

AB - Introduction The prorenin receptor ((P)RR) contributes to the regulation of the tissue renin-angiotensin system (RAS) and the function of V-ATPase, which are essential for Wnt signaling. Thus, (P)RRs may be involved in the control both of feto-placental and maternal circulation during pregnancy. This study was conducted to clarify how placental (P)RR expression and plasma soluble (P)RR [s(P)RR] levels are associated with blood pressure elevations and renal function during pregnancy. Methods We conducted a cross-sectional study, conducted at Saitama medical center in 2010-2013. Preeclamptic women (n = 16) diagnosed according to the criteria of Japan Society of Obstetrics and Gynecology and normotensive pregnant women (n = 15) participated in the study. We measured the expression of (P)RR in the placenta, plasma s(P)RR levels, systolic blood pressure (SBP), and estimated glomerular filtration rate (EGFR). Results Placental expression of (P)RR was significantly higher in preeclamptic women than in normotensive pregnant women. The plasma s(P)RR levels were significantly higher in preeclamptic women than in normotensive pregnant women. Systolic blood pressure (SBP) was positively correlated with placental (P)RR levels (P = 0.0001) and plasma s(P)RR levels (P = 0.005) in all pregnant women. In preeclamptic women, SBP was positively correlated with placental (P)RR levels (P = 0.004), but not with plasma s(P)RR levels (P = 0.15). The EGFR was negatively correlated with placental (P)RR levels (P = 0.02) and plasma s(P)RR levels (P = 0.0002) in all pregnant women. In preeclamptic women, EGFR was negatively correlated with plasma s(P)RR levels (P = 0.006), but not with placental (P)RR levels (P = 0.93). Discussion Placental (P)RR can be involved in blood pressure regulation via the tissue RAS. On the other hand, plasma s(P)RR may be involved in the pathogenesis of decreased renal function in preeclampsia.

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