Plasma 25-hydroxyvitamin D and colorectal cancer risk according to tumour immunity status

Mingyang Song, Reiko Nishihara, Molin Wang, Andrew T. Chan, Zhi Rong Qian, Kentaro Inamura, Xuehong Zhang, Kimmie Ng, Sun A. Kim, Kosuke Mima, Yasutaka Sukawa, Katsuhiko Nosho, Charles S. Fuchs, Edward L. Giovannucci, Kana Wu, Shuji Ogino

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Abstract

Objective Evidence suggests protective effects of vitamin D and antitumour immunity on colorectal cancer risk. Immune cells in tumour microenvironment can convert 25-hydroxyvitamin D [25(OH)D] to bioactive 1α,25- dihydroxyvitamin D3, which influences neoplastic and immune cells as an autocrine and paracrine factor. Thus, we hypothesised that the inverse association between vitamin D and colorectal cancer risk might be stronger for cancers with high-level immune response than those with low-level immune response. Design We designed a nested case-control study (318 rectal and colon carcinoma cases and 624 matched controls) within the Nurses' Health Study and Health Professionals Follow-up Study using molecular pathological epidemiology database. Multivariable conditional logistic regression was used to assess the association of plasma 25 (OH)D with tumour subtypes according to the degree of lymphocytic reaction, tumour-infiltrating T cells (CD3+, CD8+, CD45RO+ (PTPRC) and FOXP3+ cells), microsatellite instability or CpG island methylator phenotype. Results The association of plasma 25(OH)D with colorectal carcinoma differed by the degree of intratumoural periglandular reaction (p for heterogeneity=0.001); high 25(OH)D was associated with lower risk of tumour with high-level reaction (comparing the highest versus lowest tertile: OR 0.10; 95% CI 0.03 to 0.35; p for trend0.50). A statistically non-significant difference was observed for the associations of 25(OH)D with tumour subtypes according to CD3+ T cell density (p for heterogeneity=0.03; adjusted statistical significance level of α=0.006). Conclusions High plasma 25(OH)D level is associated with lower risk of colorectal cancer with intense immune reaction, supporting a role of vitamin D in cancer immunoprevention through tumour-host interaction.

Original languageEnglish
Pages (from-to)296-304
Number of pages9
JournalGut
Volume65
Issue number2
DOIs
Publication statusPublished - 2016 Feb 1
Externally publishedYes

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ASJC Scopus subject areas

  • Gastroenterology

Cite this

Song, M., Nishihara, R., Wang, M., Chan, A. T., Qian, Z. R., Inamura, K., Zhang, X., Ng, K., Kim, S. A., Mima, K., Sukawa, Y., Nosho, K., Fuchs, C. S., Giovannucci, E. L., Wu, K., & Ogino, S. (2016). Plasma 25-hydroxyvitamin D and colorectal cancer risk according to tumour immunity status. Gut, 65(2), 296-304. https://doi.org/10.1136/gutjnl-2014-308852