Plasma 25-hydroxyvitamin d is independently associated with hemoglobin concentration in male subjects with type 2 diabetes mellitus

Shu Meguro, Masuomi Tomita, Takeshi Katsuki, Kiyoe Kato, Henpiru Oh, Akira Ainai, Ryo Ito, Shu Takeda, Toshihide Kawai, Yoshihito Atsumi, Hiroshi Itoh, Hideki Hasegawa

Research output: Contribution to journalArticle

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Abstract

Introduction. It was reported that 25-hydroxyvitamin D level was independently associated with anemia in chronic kidney diseases, but the relation between vitamin D and anemia in diabetes mellitus is not still certain. We analyzed the relation between plasma 25-hydroxyvitamin D level and hemoglobin concentration. Materials and Methods. A cross-sectional study in male patients with type 2 diabetes was performed. Correlation coefficients and standardized partial regression coefficient for the hemoglobin concentration were evaluated. Results. Hemoglobin concentration was positively correlated with body mass index, HbA1c, estimated glomerular filtration rate, cholinesterase, and 25-hydroxyvitamin D level and negatively correlated with age, duration of diabetes mellitus, serum creatinine, and urinary albumin creatinine ratio. Multiple regression analysis revealed the independent relation of 25-hydroxyvitamin D to hemoglobin concentration. Conclusions. Plasma circulating form of vitamin D is significantly associated with hemoglobin concentration in diabetes mellitus independent of the clinical markers for kidney function or nutrition.

Original languageEnglish
Article number362981
JournalInternational Journal of Endocrinology
Volume2011
DOIs
Publication statusPublished - 2011

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Type 2 Diabetes Mellitus
Hemoglobins
Diabetes Mellitus
Vitamin D
Anemia
Creatinine
Cholinesterases
Glomerular Filtration Rate
Chronic Renal Insufficiency
Albumins
Body Mass Index
Cross-Sectional Studies
Biomarkers
Regression Analysis
Kidney
25-hydroxyvitamin D
Serum

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Plasma 25-hydroxyvitamin d is independently associated with hemoglobin concentration in male subjects with type 2 diabetes mellitus. / Meguro, Shu; Tomita, Masuomi; Katsuki, Takeshi; Kato, Kiyoe; Oh, Henpiru; Ainai, Akira; Ito, Ryo; Takeda, Shu; Kawai, Toshihide; Atsumi, Yoshihito; Itoh, Hiroshi; Hasegawa, Hideki.

In: International Journal of Endocrinology, Vol. 2011, 362981, 2011.

Research output: Contribution to journalArticle

Meguro, Shu ; Tomita, Masuomi ; Katsuki, Takeshi ; Kato, Kiyoe ; Oh, Henpiru ; Ainai, Akira ; Ito, Ryo ; Takeda, Shu ; Kawai, Toshihide ; Atsumi, Yoshihito ; Itoh, Hiroshi ; Hasegawa, Hideki. / Plasma 25-hydroxyvitamin d is independently associated with hemoglobin concentration in male subjects with type 2 diabetes mellitus. In: International Journal of Endocrinology. 2011 ; Vol. 2011.
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abstract = "Introduction. It was reported that 25-hydroxyvitamin D level was independently associated with anemia in chronic kidney diseases, but the relation between vitamin D and anemia in diabetes mellitus is not still certain. We analyzed the relation between plasma 25-hydroxyvitamin D level and hemoglobin concentration. Materials and Methods. A cross-sectional study in male patients with type 2 diabetes was performed. Correlation coefficients and standardized partial regression coefficient for the hemoglobin concentration were evaluated. Results. Hemoglobin concentration was positively correlated with body mass index, HbA1c, estimated glomerular filtration rate, cholinesterase, and 25-hydroxyvitamin D level and negatively correlated with age, duration of diabetes mellitus, serum creatinine, and urinary albumin creatinine ratio. Multiple regression analysis revealed the independent relation of 25-hydroxyvitamin D to hemoglobin concentration. Conclusions. Plasma circulating form of vitamin D is significantly associated with hemoglobin concentration in diabetes mellitus independent of the clinical markers for kidney function or nutrition.",
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AU - Meguro, Shu

AU - Tomita, Masuomi

AU - Katsuki, Takeshi

AU - Kato, Kiyoe

AU - Oh, Henpiru

AU - Ainai, Akira

AU - Ito, Ryo

AU - Takeda, Shu

AU - Kawai, Toshihide

AU - Atsumi, Yoshihito

AU - Itoh, Hiroshi

AU - Hasegawa, Hideki

PY - 2011

Y1 - 2011

N2 - Introduction. It was reported that 25-hydroxyvitamin D level was independently associated with anemia in chronic kidney diseases, but the relation between vitamin D and anemia in diabetes mellitus is not still certain. We analyzed the relation between plasma 25-hydroxyvitamin D level and hemoglobin concentration. Materials and Methods. A cross-sectional study in male patients with type 2 diabetes was performed. Correlation coefficients and standardized partial regression coefficient for the hemoglobin concentration were evaluated. Results. Hemoglobin concentration was positively correlated with body mass index, HbA1c, estimated glomerular filtration rate, cholinesterase, and 25-hydroxyvitamin D level and negatively correlated with age, duration of diabetes mellitus, serum creatinine, and urinary albumin creatinine ratio. Multiple regression analysis revealed the independent relation of 25-hydroxyvitamin D to hemoglobin concentration. Conclusions. Plasma circulating form of vitamin D is significantly associated with hemoglobin concentration in diabetes mellitus independent of the clinical markers for kidney function or nutrition.

AB - Introduction. It was reported that 25-hydroxyvitamin D level was independently associated with anemia in chronic kidney diseases, but the relation between vitamin D and anemia in diabetes mellitus is not still certain. We analyzed the relation between plasma 25-hydroxyvitamin D level and hemoglobin concentration. Materials and Methods. A cross-sectional study in male patients with type 2 diabetes was performed. Correlation coefficients and standardized partial regression coefficient for the hemoglobin concentration were evaluated. Results. Hemoglobin concentration was positively correlated with body mass index, HbA1c, estimated glomerular filtration rate, cholinesterase, and 25-hydroxyvitamin D level and negatively correlated with age, duration of diabetes mellitus, serum creatinine, and urinary albumin creatinine ratio. Multiple regression analysis revealed the independent relation of 25-hydroxyvitamin D to hemoglobin concentration. Conclusions. Plasma circulating form of vitamin D is significantly associated with hemoglobin concentration in diabetes mellitus independent of the clinical markers for kidney function or nutrition.

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