Plasma 5-hydroxytryptamine (5-HT) in migraine during an attack-free period

Eiichiro Nagata, Mamoru Shibata, Junichi Hamada, Toshihiko Shimizu, Yuki Katoh, Kyoko Gotoh, Norihiro Suzuki

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Objective. - We measured the plasma 5-HT, 5-hydroxytryptophan (5-HTP), and tryptophan levels in controls, migraine patients with aura (MWA), and migraine patients without aura (MWoA) during an attack-free period. Background. - Serotonin (5-hydroxytryptamine, 5-HT) has been implicated in the pathophysiology of migraine. The precise relationship between 5-HT and migraine, however, remains unclear. Methods. - Blood samples in controls, MWA, and MWoA patients during an attack-free period were collected from brachial arteries and analyzed using HPLC. Results. - The plasma tryptophan and 5-HTP levels were not significantly different between the controls and migraine patients (either MWA or MWoA). However, the plasma 5-HT level in the MWA patients was significantly lower than that in the controls and MWoA patients. Conclusions. - The present data suggest that reduced levels of 5-HT in MWA may result from either a dysfunction in the enzymes involved in serotonin biosynthesis or a dysfunction in 5-HT release or uptake from platelets and lymphocytes. These findings indicate the existence of a serotonin metabolism dysfunction in MWA patients that may differ from the state of serotonin metabolism in MWoA patients.

Original languageEnglish
Pages (from-to)592-596
Number of pages5
JournalHeadache
Volume46
Issue number4
DOIs
Publication statusPublished - 2006 Apr

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Migraine Disorders
Serotonin
Migraine with Aura
Migraine without Aura
5-Hydroxytryptophan
Tryptophan
Brachial Artery

Keywords

  • 5-hydroxytryptophan
  • Migraine with aura
  • Serotonin
  • Tryptophan

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Nagata, E., Shibata, M., Hamada, J., Shimizu, T., Katoh, Y., Gotoh, K., & Suzuki, N. (2006). Plasma 5-hydroxytryptamine (5-HT) in migraine during an attack-free period. Headache, 46(4), 592-596. https://doi.org/10.1111/j.1526-4610.2006.00408.x

Plasma 5-hydroxytryptamine (5-HT) in migraine during an attack-free period. / Nagata, Eiichiro; Shibata, Mamoru; Hamada, Junichi; Shimizu, Toshihiko; Katoh, Yuki; Gotoh, Kyoko; Suzuki, Norihiro.

In: Headache, Vol. 46, No. 4, 04.2006, p. 592-596.

Research output: Contribution to journalArticle

Nagata, E, Shibata, M, Hamada, J, Shimizu, T, Katoh, Y, Gotoh, K & Suzuki, N 2006, 'Plasma 5-hydroxytryptamine (5-HT) in migraine during an attack-free period', Headache, vol. 46, no. 4, pp. 592-596. https://doi.org/10.1111/j.1526-4610.2006.00408.x
Nagata, Eiichiro ; Shibata, Mamoru ; Hamada, Junichi ; Shimizu, Toshihiko ; Katoh, Yuki ; Gotoh, Kyoko ; Suzuki, Norihiro. / Plasma 5-hydroxytryptamine (5-HT) in migraine during an attack-free period. In: Headache. 2006 ; Vol. 46, No. 4. pp. 592-596.
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