Plasma antimicrobial peptide LL-37 level is inversely associated with HDL cholesterol level in patients with type 2 diabetes mellitus

Shu Meguro, Masuomi Tomita, Takeshi Katsuki, Kiyoe Kato, Henpiru Oh, Akira Ainai, Ryo Ito, Toshihide Kawai, Hiroshi Itoh, Hideki Hasegawa

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Introduction. Relation between atherosclerosis and innate immunity has attracted attention. As the antimicrobial peptide, LL-37, could have an important role in atherosclerosis, we supposed that there could be a meaningful association of plasma LL-37 level with risk factors for cardiovascular disease in subjects with type 2 diabetes mellitus. Materials and Methods. We evaluated plasma LL-37 level and other clinical markers in Japanese subjects with type 2 diabetes mellitus (n=133, 115 men and 18 women; age 64.7±11.5 years; HbA1c 8.1±1.6%). Plasma level of LL-37 was measured by ELISA. Results. Mean plasma LL-37 level was 71.2±22.3 ng/mL. Plasma LL-37 level showed significant correlations with HDL cholesterol (r=-0.450, P<0.01), triglyceride (r=0.445, P<0.01), and high sensitive C-reactive protein (r=0.316, P<0.01) but no significant correlation with age, body mass index, HbA1c, estimated glomerular filtration rate, 25-hydroxyvitamin D, or vitamin D binding protein. Multiple linear regression analysis showed significant correlations of plasma LL-37 level with HDL cholesterol (β=-0.411, P<0.01) and high sensitive C-reactive protein (β=0.193, P<0.05). Conclusion. Plasma LL-37 level was positively correlated with inflammatory markers and negatively correlated with HDL cholesterol in patients with type 2 diabetes mellitus.

Original languageEnglish
Article number703696
JournalInternational Journal of Endocrinology
Volume2014
DOIs
Publication statusPublished - 2014

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Type 2 Diabetes Mellitus
HDL Cholesterol
C-Reactive Protein
Atherosclerosis
Vitamin D-Binding Protein
antimicrobial peptide LL-37
Glomerular Filtration Rate
Innate Immunity
Linear Models
Triglycerides
Body Mass Index
Cardiovascular Diseases
Biomarkers
Enzyme-Linked Immunosorbent Assay
Regression Analysis

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Plasma antimicrobial peptide LL-37 level is inversely associated with HDL cholesterol level in patients with type 2 diabetes mellitus. / Meguro, Shu; Tomita, Masuomi; Katsuki, Takeshi; Kato, Kiyoe; Oh, Henpiru; Ainai, Akira; Ito, Ryo; Kawai, Toshihide; Itoh, Hiroshi; Hasegawa, Hideki.

In: International Journal of Endocrinology, Vol. 2014, 703696, 2014.

Research output: Contribution to journalArticle

Meguro, Shu ; Tomita, Masuomi ; Katsuki, Takeshi ; Kato, Kiyoe ; Oh, Henpiru ; Ainai, Akira ; Ito, Ryo ; Kawai, Toshihide ; Itoh, Hiroshi ; Hasegawa, Hideki. / Plasma antimicrobial peptide LL-37 level is inversely associated with HDL cholesterol level in patients with type 2 diabetes mellitus. In: International Journal of Endocrinology. 2014 ; Vol. 2014.
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abstract = "Introduction. Relation between atherosclerosis and innate immunity has attracted attention. As the antimicrobial peptide, LL-37, could have an important role in atherosclerosis, we supposed that there could be a meaningful association of plasma LL-37 level with risk factors for cardiovascular disease in subjects with type 2 diabetes mellitus. Materials and Methods. We evaluated plasma LL-37 level and other clinical markers in Japanese subjects with type 2 diabetes mellitus (n=133, 115 men and 18 women; age 64.7±11.5 years; HbA1c 8.1±1.6{\%}). Plasma level of LL-37 was measured by ELISA. Results. Mean plasma LL-37 level was 71.2±22.3 ng/mL. Plasma LL-37 level showed significant correlations with HDL cholesterol (r=-0.450, P<0.01), triglyceride (r=0.445, P<0.01), and high sensitive C-reactive protein (r=0.316, P<0.01) but no significant correlation with age, body mass index, HbA1c, estimated glomerular filtration rate, 25-hydroxyvitamin D, or vitamin D binding protein. Multiple linear regression analysis showed significant correlations of plasma LL-37 level with HDL cholesterol (β=-0.411, P<0.01) and high sensitive C-reactive protein (β=0.193, P<0.05). Conclusion. Plasma LL-37 level was positively correlated with inflammatory markers and negatively correlated with HDL cholesterol in patients with type 2 diabetes mellitus.",
author = "Shu Meguro and Masuomi Tomita and Takeshi Katsuki and Kiyoe Kato and Henpiru Oh and Akira Ainai and Ryo Ito and Toshihide Kawai and Hiroshi Itoh and Hideki Hasegawa",
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AU - Meguro, Shu

AU - Tomita, Masuomi

AU - Katsuki, Takeshi

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AU - Oh, Henpiru

AU - Ainai, Akira

AU - Ito, Ryo

AU - Kawai, Toshihide

AU - Itoh, Hiroshi

AU - Hasegawa, Hideki

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N2 - Introduction. Relation between atherosclerosis and innate immunity has attracted attention. As the antimicrobial peptide, LL-37, could have an important role in atherosclerosis, we supposed that there could be a meaningful association of plasma LL-37 level with risk factors for cardiovascular disease in subjects with type 2 diabetes mellitus. Materials and Methods. We evaluated plasma LL-37 level and other clinical markers in Japanese subjects with type 2 diabetes mellitus (n=133, 115 men and 18 women; age 64.7±11.5 years; HbA1c 8.1±1.6%). Plasma level of LL-37 was measured by ELISA. Results. Mean plasma LL-37 level was 71.2±22.3 ng/mL. Plasma LL-37 level showed significant correlations with HDL cholesterol (r=-0.450, P<0.01), triglyceride (r=0.445, P<0.01), and high sensitive C-reactive protein (r=0.316, P<0.01) but no significant correlation with age, body mass index, HbA1c, estimated glomerular filtration rate, 25-hydroxyvitamin D, or vitamin D binding protein. Multiple linear regression analysis showed significant correlations of plasma LL-37 level with HDL cholesterol (β=-0.411, P<0.01) and high sensitive C-reactive protein (β=0.193, P<0.05). Conclusion. Plasma LL-37 level was positively correlated with inflammatory markers and negatively correlated with HDL cholesterol in patients with type 2 diabetes mellitus.

AB - Introduction. Relation between atherosclerosis and innate immunity has attracted attention. As the antimicrobial peptide, LL-37, could have an important role in atherosclerosis, we supposed that there could be a meaningful association of plasma LL-37 level with risk factors for cardiovascular disease in subjects with type 2 diabetes mellitus. Materials and Methods. We evaluated plasma LL-37 level and other clinical markers in Japanese subjects with type 2 diabetes mellitus (n=133, 115 men and 18 women; age 64.7±11.5 years; HbA1c 8.1±1.6%). Plasma level of LL-37 was measured by ELISA. Results. Mean plasma LL-37 level was 71.2±22.3 ng/mL. Plasma LL-37 level showed significant correlations with HDL cholesterol (r=-0.450, P<0.01), triglyceride (r=0.445, P<0.01), and high sensitive C-reactive protein (r=0.316, P<0.01) but no significant correlation with age, body mass index, HbA1c, estimated glomerular filtration rate, 25-hydroxyvitamin D, or vitamin D binding protein. Multiple linear regression analysis showed significant correlations of plasma LL-37 level with HDL cholesterol (β=-0.411, P<0.01) and high sensitive C-reactive protein (β=0.193, P<0.05). Conclusion. Plasma LL-37 level was positively correlated with inflammatory markers and negatively correlated with HDL cholesterol in patients with type 2 diabetes mellitus.

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