Plasma catecholamine response to tracheal intubation after midazolam and vecuronium in elderly patients with hypertension

Y. Takino, T. Kaneda, Hiroshi Morisaki

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

This study was undertaken to determine whether midazolam alleviates sympathoadrenal response evoked by tracheal intubation in elderly patients with hypertension. Anesthesia was induced with midazolam in a sleep dose followed by vecuronium 0.1 mg · kg-1. Heart rate and blood pressure were recorded before, 1 and 3 minutes after induction with intubation. Free and total catecholamine (CA) in plasma were measured at each time. Dopamine, norepinephrine and epinephrine (EN) were determined using fluorescens derivatization with diphenylethylenediamine by HPLC. Although heart rate and diastolic pressure rose in some degree 1 min after intubation, free and total CA concentrations did not increase during study period. Free and total EN levels decreased significantly 3 min after intubation. The absence of elevation in plasma CA concentrations, especially in free CA, which is physiologically active, would contribute to produce circulatory stability on laryngoscopy and tracheal intubation. However, the mystery of why hyperdynamic state was produced without the increase in CA concentrations remains to be solved, even though it occurred for a short period of time.

Original languageEnglish
Pages (from-to)1669-1672
Number of pages4
JournalJapanese Journal of Anesthesiology
Volume39
Issue number12
Publication statusPublished - 1990
Externally publishedYes

Fingerprint

Vecuronium Bromide
Midazolam
Intubation
Catecholamines
Hypertension
Epinephrine
Heart Rate
Blood Pressure
Laryngoscopy
Dopamine
Norepinephrine
Sleep
Anesthesia
High Pressure Liquid Chromatography

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

Cite this

Plasma catecholamine response to tracheal intubation after midazolam and vecuronium in elderly patients with hypertension. / Takino, Y.; Kaneda, T.; Morisaki, Hiroshi.

In: Japanese Journal of Anesthesiology, Vol. 39, No. 12, 1990, p. 1669-1672.

Research output: Contribution to journalArticle

@article{250aeef06c9241dc8abed83fa90cd7e2,
title = "Plasma catecholamine response to tracheal intubation after midazolam and vecuronium in elderly patients with hypertension",
abstract = "This study was undertaken to determine whether midazolam alleviates sympathoadrenal response evoked by tracheal intubation in elderly patients with hypertension. Anesthesia was induced with midazolam in a sleep dose followed by vecuronium 0.1 mg · kg-1. Heart rate and blood pressure were recorded before, 1 and 3 minutes after induction with intubation. Free and total catecholamine (CA) in plasma were measured at each time. Dopamine, norepinephrine and epinephrine (EN) were determined using fluorescens derivatization with diphenylethylenediamine by HPLC. Although heart rate and diastolic pressure rose in some degree 1 min after intubation, free and total CA concentrations did not increase during study period. Free and total EN levels decreased significantly 3 min after intubation. The absence of elevation in plasma CA concentrations, especially in free CA, which is physiologically active, would contribute to produce circulatory stability on laryngoscopy and tracheal intubation. However, the mystery of why hyperdynamic state was produced without the increase in CA concentrations remains to be solved, even though it occurred for a short period of time.",
author = "Y. Takino and T. Kaneda and Hiroshi Morisaki",
year = "1990",
language = "English",
volume = "39",
pages = "1669--1672",
journal = "Japanese Journal of Anesthesiology",
issn = "0021-4892",
publisher = "Kokuseido Publishing Co. Ltd",
number = "12",

}

TY - JOUR

T1 - Plasma catecholamine response to tracheal intubation after midazolam and vecuronium in elderly patients with hypertension

AU - Takino, Y.

AU - Kaneda, T.

AU - Morisaki, Hiroshi

PY - 1990

Y1 - 1990

N2 - This study was undertaken to determine whether midazolam alleviates sympathoadrenal response evoked by tracheal intubation in elderly patients with hypertension. Anesthesia was induced with midazolam in a sleep dose followed by vecuronium 0.1 mg · kg-1. Heart rate and blood pressure were recorded before, 1 and 3 minutes after induction with intubation. Free and total catecholamine (CA) in plasma were measured at each time. Dopamine, norepinephrine and epinephrine (EN) were determined using fluorescens derivatization with diphenylethylenediamine by HPLC. Although heart rate and diastolic pressure rose in some degree 1 min after intubation, free and total CA concentrations did not increase during study period. Free and total EN levels decreased significantly 3 min after intubation. The absence of elevation in plasma CA concentrations, especially in free CA, which is physiologically active, would contribute to produce circulatory stability on laryngoscopy and tracheal intubation. However, the mystery of why hyperdynamic state was produced without the increase in CA concentrations remains to be solved, even though it occurred for a short period of time.

AB - This study was undertaken to determine whether midazolam alleviates sympathoadrenal response evoked by tracheal intubation in elderly patients with hypertension. Anesthesia was induced with midazolam in a sleep dose followed by vecuronium 0.1 mg · kg-1. Heart rate and blood pressure were recorded before, 1 and 3 minutes after induction with intubation. Free and total catecholamine (CA) in plasma were measured at each time. Dopamine, norepinephrine and epinephrine (EN) were determined using fluorescens derivatization with diphenylethylenediamine by HPLC. Although heart rate and diastolic pressure rose in some degree 1 min after intubation, free and total CA concentrations did not increase during study period. Free and total EN levels decreased significantly 3 min after intubation. The absence of elevation in plasma CA concentrations, especially in free CA, which is physiologically active, would contribute to produce circulatory stability on laryngoscopy and tracheal intubation. However, the mystery of why hyperdynamic state was produced without the increase in CA concentrations remains to be solved, even though it occurred for a short period of time.

UR - http://www.scopus.com/inward/record.url?scp=0025613910&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025613910&partnerID=8YFLogxK

M3 - Article

C2 - 1983026

AN - SCOPUS:0025613910

VL - 39

SP - 1669

EP - 1672

JO - Japanese Journal of Anesthesiology

JF - Japanese Journal of Anesthesiology

SN - 0021-4892

IS - 12

ER -