Plasma concentration of acetylcholine in young women

Koichiro Kawashima; Hisayo Oohata; Kazuko Fujimoto; Takeshi Suzuki

doi:10.1016/0304-3940(87)90478-2

Plasma concentration of acetylcholine in young women

Koichiro Kawashima, Hisayo Oohata, Kazuko Fujimoto, Takeshi Suzuki

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

A sensitive and specific radioimmunoassay was applied to the determination of acetylcholine (ACh) in plasma. The concentration of ACh in plasma sampled from 32 young women was 456.1 ± 53.1 (mean ± S.E.M.) pg/ml. No significant correlations were observed between plasma concentration of ACh and acetylcholinesterase (AChE) activity, or gonadal hormones. These data demonstrate that an amount of ACh measurable by radioimmunoassay is present in plasma and plasma ACh is not regulated by AChE activity and the menstrual cycle in young women. The origin and physiological as well as pathophysiological significance of ACh in plasma remain to be clarified.

Original language	English
Pages (from-to)	339-342
Number of pages	4
Journal	Neuroscience Letters
Volume	80
Issue number	3
DOIs	https://doi.org/10.1016/0304-3940(87)90478-2
Publication status	Published - 1987 Oct 5

Keywords

Acetylcholinesterase
Gonadal hormone
Menstrual cycle
Plasma acetylcholine
Radioimmunoassay
Young woman

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/0304-3940(87)90478-2

Cite this

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abstract = "A sensitive and specific radioimmunoassay was applied to the determination of acetylcholine (ACh) in plasma. The concentration of ACh in plasma sampled from 32 young women was 456.1 ± 53.1 (mean ± S.E.M.) pg/ml. No significant correlations were observed between plasma concentration of ACh and acetylcholinesterase (AChE) activity, or gonadal hormones. These data demonstrate that an amount of ACh measurable by radioimmunoassay is present in plasma and plasma ACh is not regulated by AChE activity and the menstrual cycle in young women. The origin and physiological as well as pathophysiological significance of ACh in plasma remain to be clarified.",

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AU - Kawashima, Koichiro

AU - Oohata, Hisayo

AU - Fujimoto, Kazuko

AU - Suzuki, Takeshi

PY - 1987/10/5

Y1 - 1987/10/5

N2 - A sensitive and specific radioimmunoassay was applied to the determination of acetylcholine (ACh) in plasma. The concentration of ACh in plasma sampled from 32 young women was 456.1 ± 53.1 (mean ± S.E.M.) pg/ml. No significant correlations were observed between plasma concentration of ACh and acetylcholinesterase (AChE) activity, or gonadal hormones. These data demonstrate that an amount of ACh measurable by radioimmunoassay is present in plasma and plasma ACh is not regulated by AChE activity and the menstrual cycle in young women. The origin and physiological as well as pathophysiological significance of ACh in plasma remain to be clarified.

AB - A sensitive and specific radioimmunoassay was applied to the determination of acetylcholine (ACh) in plasma. The concentration of ACh in plasma sampled from 32 young women was 456.1 ± 53.1 (mean ± S.E.M.) pg/ml. No significant correlations were observed between plasma concentration of ACh and acetylcholinesterase (AChE) activity, or gonadal hormones. These data demonstrate that an amount of ACh measurable by radioimmunoassay is present in plasma and plasma ACh is not regulated by AChE activity and the menstrual cycle in young women. The origin and physiological as well as pathophysiological significance of ACh in plasma remain to be clarified.

KW - Acetylcholinesterase

KW - Gonadal hormone

KW - Menstrual cycle

KW - Plasma acetylcholine

KW - Radioimmunoassay

KW - Young woman

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Plasma concentration of acetylcholine in young women

Abstract

Keywords

ASJC Scopus subject areas

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