Abstract
Chronic obstructive pulmonary disease (COPD) develops only in smoking-sensitive smokers and manifests heterogeneous phenotypes, including emphysema and non-emphysema types. We aimed to identify biomarkers related to the smoking-sensitivity and phenotypes of COPD. Among 240 smokers suggestive of COPD, we studied on four groups defined by % forced expiratory volume in one second (FEV1) and computed tomography-based pulmonary emphysema. Plasma concentrations of 33 inflammatory markers were measured in four groups as well as Non-smokers using multiplex protein arrays. IL-5, IL-7 and IL-13 were identified to be associated with smoking sensitivity and IL-6 and IL-10 were candidate biomarkers for airway-lesion dominant COPD.
Original language | English |
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Pages (from-to) | 368-377 |
Number of pages | 10 |
Journal | Biomarkers |
Volume | 19 |
Issue number | 5 |
DOIs | |
Publication status | Published - 2014 Aug |
Keywords
- Airflow limitation
- Chronic obstructive pulmonary disease
- Emphysema
- Inflammatory cytokine
- Plasma biomarker
ASJC Scopus subject areas
- Biochemistry
- Clinical Biochemistry
- Health, Toxicology and Mutagenesis