Plasma cytokine profiles related to smoking-sensitivity and phenotypes of chronic obstructive pulmonary disease

Miho Nakamura, Hidetoshi Nakamura, Naoto Minematsu, Shotaro Chubachi, Masaki Miyazaki, Shuichi Yoshida, Keishi Tsuduki, Toru Shirahata, Shuko Mashimo, Saeko Takahashi, Takahiro Nakajima, Hiroki Tateno, Seitaro Fujishima, Tomoko Betsuyaku

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Chronic obstructive pulmonary disease (COPD) develops only in smoking-sensitive smokers and manifests heterogeneous phenotypes, including emphysema and non-emphysema types. We aimed to identify biomarkers related to the smoking-sensitivity and phenotypes of COPD. Among 240 smokers suggestive of COPD, we studied on four groups defined by % forced expiratory volume in one second (FEV1) and computed tomography-based pulmonary emphysema. Plasma concentrations of 33 inflammatory markers were measured in four groups as well as Non-smokers using multiplex protein arrays. IL-5, IL-7 and IL-13 were identified to be associated with smoking sensitivity and IL-6 and IL-10 were candidate biomarkers for airway-lesion dominant COPD.

Original languageEnglish
Pages (from-to)368-377
Number of pages10
JournalBiomarkers
Volume19
Issue number5
DOIs
Publication statusPublished - 2014 Aug

Keywords

  • Airflow limitation
  • Chronic obstructive pulmonary disease
  • Emphysema
  • Inflammatory cytokine
  • Plasma biomarker

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Health, Toxicology and Mutagenesis

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    Nakamura, M., Nakamura, H., Minematsu, N., Chubachi, S., Miyazaki, M., Yoshida, S., Tsuduki, K., Shirahata, T., Mashimo, S., Takahashi, S., Nakajima, T., Tateno, H., Fujishima, S., & Betsuyaku, T. (2014). Plasma cytokine profiles related to smoking-sensitivity and phenotypes of chronic obstructive pulmonary disease. Biomarkers, 19(5), 368-377. https://doi.org/10.3109/1354750X.2014.915342