Plasma cytokine profiles related to smoking-sensitivity and phenotypes of chronic obstructive pulmonary disease

Miho Nakamura; Hidetoshi Nakamura; Naoto Minematsu; Shotaro Chubachi; Masaki Miyazaki; Shuichi Yoshida; Keishi Tsuduki; Toru Shirahata; Shuko Mashimo; Saeko Takahashi; Takahiro Nakajima; Hiroki Tateno; Seitaro Fujishima; Tomoko Betsuyaku

doi:10.3109/1354750X.2014.915342

Plasma cytokine profiles related to smoking-sensitivity and phenotypes of chronic obstructive pulmonary disease

Miho Nakamura, Hidetoshi Nakamura, Naoto Minematsu, Shotaro Chubachi, Masaki Miyazaki, Shuichi Yoshida, Keishi Tsuduki, Toru Shirahata, Shuko Mashimo, Saeko Takahashi, Takahiro Nakajima, Hiroki Tateno, Seitaro Fujishima, Tomoko Betsuyaku

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Chronic obstructive pulmonary disease (COPD) develops only in smoking-sensitive smokers and manifests heterogeneous phenotypes, including emphysema and non-emphysema types. We aimed to identify biomarkers related to the smoking-sensitivity and phenotypes of COPD. Among 240 smokers suggestive of COPD, we studied on four groups defined by % forced expiratory volume in one second (FEV1) and computed tomography-based pulmonary emphysema. Plasma concentrations of 33 inflammatory markers were measured in four groups as well as Non-smokers using multiplex protein arrays. IL-5, IL-7 and IL-13 were identified to be associated with smoking sensitivity and IL-6 and IL-10 were candidate biomarkers for airway-lesion dominant COPD.

Original language	English
Pages (from-to)	368-377
Number of pages	10
Journal	Biomarkers
Volume	19
Issue number	5
DOIs	https://doi.org/10.3109/1354750X.2014.915342
Publication status	Published - 2014 Aug

Keywords

Airflow limitation
Chronic obstructive pulmonary disease
Emphysema
Inflammatory cytokine
Plasma biomarker

ASJC Scopus subject areas

Biochemistry
Clinical Biochemistry
Health, Toxicology and Mutagenesis

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10.3109/1354750X.2014.915342

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Nakamura, M., Nakamura, H., Minematsu, N., Chubachi, S., Miyazaki, M., Yoshida, S., Tsuduki, K., Shirahata, T., Mashimo, S., Takahashi, S., Nakajima, T., Tateno, H., Fujishima, S., & Betsuyaku, T. (2014). Plasma cytokine profiles related to smoking-sensitivity and phenotypes of chronic obstructive pulmonary disease. Biomarkers, 19(5), 368-377. https://doi.org/10.3109/1354750X.2014.915342

Nakamura, M, Nakamura, H, Minematsu, N, Chubachi, S, Miyazaki, M, Yoshida, S, Tsuduki, K, Shirahata, T, Mashimo, S, Takahashi, S, Nakajima, T, Tateno, H, Fujishima, S & Betsuyaku, T 2014, 'Plasma cytokine profiles related to smoking-sensitivity and phenotypes of chronic obstructive pulmonary disease', Biomarkers, vol. 19, no. 5, pp. 368-377. https://doi.org/10.3109/1354750X.2014.915342

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title = "Plasma cytokine profiles related to smoking-sensitivity and phenotypes of chronic obstructive pulmonary disease",

abstract = "Chronic obstructive pulmonary disease (COPD) develops only in smoking-sensitive smokers and manifests heterogeneous phenotypes, including emphysema and non-emphysema types. We aimed to identify biomarkers related to the smoking-sensitivity and phenotypes of COPD. Among 240 smokers suggestive of COPD, we studied on four groups defined by % forced expiratory volume in one second (FEV1) and computed tomography-based pulmonary emphysema. Plasma concentrations of 33 inflammatory markers were measured in four groups as well as Non-smokers using multiplex protein arrays. IL-5, IL-7 and IL-13 were identified to be associated with smoking sensitivity and IL-6 and IL-10 were candidate biomarkers for airway-lesion dominant COPD.",

keywords = "Airflow limitation, Chronic obstructive pulmonary disease, Emphysema, Inflammatory cytokine, Plasma biomarker",

author = "Miho Nakamura and Hidetoshi Nakamura and Naoto Minematsu and Shotaro Chubachi and Masaki Miyazaki and Shuichi Yoshida and Keishi Tsuduki and Toru Shirahata and Shuko Mashimo and Saeko Takahashi and Takahiro Nakajima and Hiroki Tateno and Seitaro Fujishima and Tomoko Betsuyaku",

note = "Funding Information: This study was supported in part by a grant to the Respiratory Failure Research Group from the Ministry of Health, Labour and Welfare of Japan. The authors report no declarations of interest. Copyright: Copyright 2015 Elsevier B.V., All rights reserved.",

year = "2014",

month = aug,

doi = "10.3109/1354750X.2014.915342",

language = "English",

volume = "19",

pages = "368--377",

journal = "Biomarkers",

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AU - Nakamura, Miho

AU - Nakamura, Hidetoshi

AU - Minematsu, Naoto

AU - Chubachi, Shotaro

AU - Miyazaki, Masaki

AU - Yoshida, Shuichi

AU - Tsuduki, Keishi

AU - Shirahata, Toru

AU - Mashimo, Shuko

AU - Takahashi, Saeko

AU - Nakajima, Takahiro

AU - Tateno, Hiroki

AU - Fujishima, Seitaro

AU - Betsuyaku, Tomoko

N1 - Funding Information: This study was supported in part by a grant to the Respiratory Failure Research Group from the Ministry of Health, Labour and Welfare of Japan. The authors report no declarations of interest. Copyright: Copyright 2015 Elsevier B.V., All rights reserved.

PY - 2014/8

Y1 - 2014/8

N2 - Chronic obstructive pulmonary disease (COPD) develops only in smoking-sensitive smokers and manifests heterogeneous phenotypes, including emphysema and non-emphysema types. We aimed to identify biomarkers related to the smoking-sensitivity and phenotypes of COPD. Among 240 smokers suggestive of COPD, we studied on four groups defined by % forced expiratory volume in one second (FEV1) and computed tomography-based pulmonary emphysema. Plasma concentrations of 33 inflammatory markers were measured in four groups as well as Non-smokers using multiplex protein arrays. IL-5, IL-7 and IL-13 were identified to be associated with smoking sensitivity and IL-6 and IL-10 were candidate biomarkers for airway-lesion dominant COPD.

AB - Chronic obstructive pulmonary disease (COPD) develops only in smoking-sensitive smokers and manifests heterogeneous phenotypes, including emphysema and non-emphysema types. We aimed to identify biomarkers related to the smoking-sensitivity and phenotypes of COPD. Among 240 smokers suggestive of COPD, we studied on four groups defined by % forced expiratory volume in one second (FEV1) and computed tomography-based pulmonary emphysema. Plasma concentrations of 33 inflammatory markers were measured in four groups as well as Non-smokers using multiplex protein arrays. IL-5, IL-7 and IL-13 were identified to be associated with smoking sensitivity and IL-6 and IL-10 were candidate biomarkers for airway-lesion dominant COPD.

KW - Airflow limitation

KW - Chronic obstructive pulmonary disease

KW - Emphysema

KW - Inflammatory cytokine

KW - Plasma biomarker

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Plasma cytokine profiles related to smoking-sensitivity and phenotypes of chronic obstructive pulmonary disease

Abstract

Keywords

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