Abstract
Chronic obstructive pulmonary disease (COPD) develops only in smoking-sensitive smokers and manifests heterogeneous phenotypes, including emphysema and non-emphysema types. We aimed to identify biomarkers related to the smoking-sensitivity and phenotypes of COPD. Among 240 smokers suggestive of COPD, we studied on four groups defined by % forced expiratory volume in one second (FEV1) and computed tomography-based pulmonary emphysema. Plasma concentrations of 33 inflammatory markers were measured in four groups as well as Non-smokers using multiplex protein arrays. IL-5, IL-7 and IL-13 were identified to be associated with smoking sensitivity and IL-6 and IL-10 were candidate biomarkers for airway-lesion dominant COPD.
| Original language | English |
|---|---|
| Pages (from-to) | 368-377 |
| Number of pages | 10 |
| Journal | Biomarkers |
| Volume | 19 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 2014 |
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Keywords
- Airflow limitation
- Chronic obstructive pulmonary disease
- Emphysema
- Inflammatory cytokine
- Plasma biomarker
ASJC Scopus subject areas
- Biochemistry
- Clinical Biochemistry
- Health, Toxicology and Mutagenesis
- Medicine(all)
Cite this
Plasma cytokine profiles related to smoking-sensitivity and phenotypes of chronic obstructive pulmonary disease. / Nakamura, Miho; Nakamura, Hidetoshi; Minematsu, Naoto; Chubachi, Shotaro; Miyazaki, Masaki; Yoshida, Shuichi; Tsuduki, Keishi; Shirahata, Toru; Mashimo, Shuko; Takahashi, Saeko; Nakajima, Takahiro; Tateno, Hiroki; Fujishima, Seitaro; Betsuyaku, Tomoko.
In: Biomarkers, Vol. 19, No. 5, 2014, p. 368-377.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Plasma cytokine profiles related to smoking-sensitivity and phenotypes of chronic obstructive pulmonary disease
AU - Nakamura, Miho
AU - Nakamura, Hidetoshi
AU - Minematsu, Naoto
AU - Chubachi, Shotaro
AU - Miyazaki, Masaki
AU - Yoshida, Shuichi
AU - Tsuduki, Keishi
AU - Shirahata, Toru
AU - Mashimo, Shuko
AU - Takahashi, Saeko
AU - Nakajima, Takahiro
AU - Tateno, Hiroki
AU - Fujishima, Seitaro
AU - Betsuyaku, Tomoko
PY - 2014
Y1 - 2014
N2 - Chronic obstructive pulmonary disease (COPD) develops only in smoking-sensitive smokers and manifests heterogeneous phenotypes, including emphysema and non-emphysema types. We aimed to identify biomarkers related to the smoking-sensitivity and phenotypes of COPD. Among 240 smokers suggestive of COPD, we studied on four groups defined by % forced expiratory volume in one second (FEV1) and computed tomography-based pulmonary emphysema. Plasma concentrations of 33 inflammatory markers were measured in four groups as well as Non-smokers using multiplex protein arrays. IL-5, IL-7 and IL-13 were identified to be associated with smoking sensitivity and IL-6 and IL-10 were candidate biomarkers for airway-lesion dominant COPD.
AB - Chronic obstructive pulmonary disease (COPD) develops only in smoking-sensitive smokers and manifests heterogeneous phenotypes, including emphysema and non-emphysema types. We aimed to identify biomarkers related to the smoking-sensitivity and phenotypes of COPD. Among 240 smokers suggestive of COPD, we studied on four groups defined by % forced expiratory volume in one second (FEV1) and computed tomography-based pulmonary emphysema. Plasma concentrations of 33 inflammatory markers were measured in four groups as well as Non-smokers using multiplex protein arrays. IL-5, IL-7 and IL-13 were identified to be associated with smoking sensitivity and IL-6 and IL-10 were candidate biomarkers for airway-lesion dominant COPD.
KW - Airflow limitation
KW - Chronic obstructive pulmonary disease
KW - Emphysema
KW - Inflammatory cytokine
KW - Plasma biomarker
UR - http://www.scopus.com/inward/record.url?scp=84904701248&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84904701248&partnerID=8YFLogxK
U2 - 10.3109/1354750X.2014.915342
DO - 10.3109/1354750X.2014.915342
M3 - Article
VL - 19
SP - 368
EP - 377
JO - Biomarkers
JF - Biomarkers
SN - 1354-750X
IS - 5
ER -