TY - JOUR
T1 - Plasma fibrinogen, ambulatory blood pressure, and silent cerebrovascular lesions
T2 - The Ohasama study
AU - Aono, Yoko
AU - Ohkubo, Takayoshi
AU - Kikuya, Masahiro
AU - Hara, Azusa
AU - Kondo, Takeo
AU - Obara, Taku
AU - Metoki, Hirohito
AU - Inoue, Ryusuke
AU - Asayama, Kei
AU - Shintani, Yoriko
AU - Hashimoto, Junichiro
AU - Totsune, Kazuhito
AU - Hoshi, Haruhisa
AU - Satoh, Hiroshi
AU - Izumi, Shin Ichi
AU - Imai, Yutaka
N1 - Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2007/4
Y1 - 2007/4
N2 - OBJECTIVE - Twenty-four-hour ambulatory blood pressure (24-hour ABP) values are considered a powerful predictor of stroke. Silent cerebrovascular lesions are associated with an increased risk of stroke. Because fibrinogen is a major determinant of plasma viscosity, an elevated fibrinogen level might also be associated with stroke risk. We evaluated the association of 24-hour ABP and plasma fibrinogen levels with the risk of silent cerebrovascular lesions (white matter hyperintensity and lacunar infarct) detected by MRI. METHODS AND RESULTS - The study cohort comprised 958 individuals from the general population of Ohasama, a rural Japanese community. Multiple logistic regression analysis adjusted for age, sex, smoking and drinking status, use of antihypertensive medication, body mass index, 24-hour ABP, and a history of hypercholesterolemia, diabetes mellitus, and atrial fibrillation demonstrated that each 1-SD increase in fibrinogen level was associated with a significantly increased risk of silent cerebrovascular lesions (odds ratio, 1.26; P=0.001). The 24-hour ABP was also significantly and independently associated with the risk of silent cerebrovascular lesions. Even when 24-hour ABP values were within normal range (<135/80 mm Hg), elevated fibrinogen levels were associated with an increased risk of silent cerebrovascular lesions. Fibrinogen and 24-hour BP had additive effects on silent cerebrovascular lesions. CONCLUSION - The 24-hour ABP and plasma fibrinogen levels were closely and independently associated with the risk of silent cerebrovascular lesions including white matter hyperintensity and lacunar infarct.
AB - OBJECTIVE - Twenty-four-hour ambulatory blood pressure (24-hour ABP) values are considered a powerful predictor of stroke. Silent cerebrovascular lesions are associated with an increased risk of stroke. Because fibrinogen is a major determinant of plasma viscosity, an elevated fibrinogen level might also be associated with stroke risk. We evaluated the association of 24-hour ABP and plasma fibrinogen levels with the risk of silent cerebrovascular lesions (white matter hyperintensity and lacunar infarct) detected by MRI. METHODS AND RESULTS - The study cohort comprised 958 individuals from the general population of Ohasama, a rural Japanese community. Multiple logistic regression analysis adjusted for age, sex, smoking and drinking status, use of antihypertensive medication, body mass index, 24-hour ABP, and a history of hypercholesterolemia, diabetes mellitus, and atrial fibrillation demonstrated that each 1-SD increase in fibrinogen level was associated with a significantly increased risk of silent cerebrovascular lesions (odds ratio, 1.26; P=0.001). The 24-hour ABP was also significantly and independently associated with the risk of silent cerebrovascular lesions. Even when 24-hour ABP values were within normal range (<135/80 mm Hg), elevated fibrinogen levels were associated with an increased risk of silent cerebrovascular lesions. Fibrinogen and 24-hour BP had additive effects on silent cerebrovascular lesions. CONCLUSION - The 24-hour ABP and plasma fibrinogen levels were closely and independently associated with the risk of silent cerebrovascular lesions including white matter hyperintensity and lacunar infarct.
KW - Ambulatory blood pressure
KW - Lacunar infarct
KW - Plasma fibrinogen
KW - Silent cerebrovascular lesions
KW - White matter hyperintensity
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U2 - 10.1161/01.ATV.0000258947.17570.38
DO - 10.1161/01.ATV.0000258947.17570.38
M3 - Article
C2 - 17272746
AN - SCOPUS:34247275971
VL - 27
SP - 963
EP - 968
JO - Arteriosclerosis, Thrombosis, and Vascular Biology
JF - Arteriosclerosis, Thrombosis, and Vascular Biology
SN - 1079-5642
IS - 4
ER -