Plasma-mediated tissue ablation with nanosecond laser pulses in the spectral region from ultraviolet to near-infrared: In-vitro study with porcine myocardium tissue

Shunichi Sato, Makoto Ogura, Tomoaki Shimada, Miya Ishihara, Tsunenori Arai, Takemi Matsui, Akira Kurita, Minoru Obara, Makoto Kikuchi, Hitoshi Wakisaka, Hiroshi Ashida

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

With a Q-switched Nd:YAG laser (the fundamental band and its harmonics), ablation characteristics have been investigated in vitro for porcine myocardium tissue. At a constant laser intensity of ∼ 2.0 GW/cm2, the laser pulses irradiated the tissue and the depth of the ablation hole formed was measured. After the laser irradiation, the tissue was histologically analyzed with an optical microscope and a polarization optical microscope to evaluate the laser-induced damage in the tissue. It was found that the ablation rate for a 1064-nm laser irradiation was comparably high to that for a 355-nm laser irradiation, and the ablation efficiency was lower for a 266-nm laser irradiation than for a 355-nm laser irradiation. During the ablation, strong plasma formation was observed for 266 nm and 1064 nm, while the laser-induced optical emission was dominated by fluorescence for 355 nm. The histology showed that the thermal damage thickness decreased with decreasing the wavelength for 266, 355, and 532 nm, but for 1064 nm thermal damage was very limited although a certain extent of mechanical damage was observed. Based on these experimental results, the ablation mechanism for each laser wavelength and the optimum laser wavelength for the TMLR (transmyocardial laser revascularization) are discussed.

Original languageEnglish
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsI.V. Bigio, G.J. Muller, G.J. Puppels, R.W. Steiner, K. Swanberg
Pages12-17
Number of pages6
Volume4161
DOIs
Publication statusPublished - 2000
Externally publishedYes
EventOptical Biopsy and Tissue Optics - Amsterdam, Netherlands
Duration: 2000 Jul 52000 Jul 6

Other

OtherOptical Biopsy and Tissue Optics
CountryNetherlands
CityAmsterdam
Period00/7/500/7/6

Fingerprint

myocardium
Ablation
ablation
Laser beam effects
Laser pulses
Tissue
Infrared radiation
Plasmas
Lasers
pulses
lasers
Wavelength
Microscopes
irradiation
damage
Laser damage
Histology
Light polarization
optical microscopes
Fluorescence

Keywords

  • Laser ablation
  • Laser-induced plasma
  • Mechanical damage
  • Myocardium tissue
  • Near-infrared
  • Q-switched Nd:YAG laser
  • Thermal damage
  • Transmyocardial laser revascularization (TMLR)
  • Ultraviolet

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Sato, S., Ogura, M., Shimada, T., Ishihara, M., Arai, T., Matsui, T., ... Ashida, H. (2000). Plasma-mediated tissue ablation with nanosecond laser pulses in the spectral region from ultraviolet to near-infrared: In-vitro study with porcine myocardium tissue. In I. V. Bigio, G. J. Muller, G. J. Puppels, R. W. Steiner, & K. Swanberg (Eds.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 4161, pp. 12-17) https://doi.org/10.1117/12.409316

Plasma-mediated tissue ablation with nanosecond laser pulses in the spectral region from ultraviolet to near-infrared : In-vitro study with porcine myocardium tissue. / Sato, Shunichi; Ogura, Makoto; Shimada, Tomoaki; Ishihara, Miya; Arai, Tsunenori; Matsui, Takemi; Kurita, Akira; Obara, Minoru; Kikuchi, Makoto; Wakisaka, Hitoshi; Ashida, Hiroshi.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / I.V. Bigio; G.J. Muller; G.J. Puppels; R.W. Steiner; K. Swanberg. Vol. 4161 2000. p. 12-17.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Sato, S, Ogura, M, Shimada, T, Ishihara, M, Arai, T, Matsui, T, Kurita, A, Obara, M, Kikuchi, M, Wakisaka, H & Ashida, H 2000, Plasma-mediated tissue ablation with nanosecond laser pulses in the spectral region from ultraviolet to near-infrared: In-vitro study with porcine myocardium tissue. in IV Bigio, GJ Muller, GJ Puppels, RW Steiner & K Swanberg (eds), Proceedings of SPIE - The International Society for Optical Engineering. vol. 4161, pp. 12-17, Optical Biopsy and Tissue Optics, Amsterdam, Netherlands, 00/7/5. https://doi.org/10.1117/12.409316
Sato S, Ogura M, Shimada T, Ishihara M, Arai T, Matsui T et al. Plasma-mediated tissue ablation with nanosecond laser pulses in the spectral region from ultraviolet to near-infrared: In-vitro study with porcine myocardium tissue. In Bigio IV, Muller GJ, Puppels GJ, Steiner RW, Swanberg K, editors, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 4161. 2000. p. 12-17 https://doi.org/10.1117/12.409316
Sato, Shunichi ; Ogura, Makoto ; Shimada, Tomoaki ; Ishihara, Miya ; Arai, Tsunenori ; Matsui, Takemi ; Kurita, Akira ; Obara, Minoru ; Kikuchi, Makoto ; Wakisaka, Hitoshi ; Ashida, Hiroshi. / Plasma-mediated tissue ablation with nanosecond laser pulses in the spectral region from ultraviolet to near-infrared : In-vitro study with porcine myocardium tissue. Proceedings of SPIE - The International Society for Optical Engineering. editor / I.V. Bigio ; G.J. Muller ; G.J. Puppels ; R.W. Steiner ; K. Swanberg. Vol. 4161 2000. pp. 12-17
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abstract = "With a Q-switched Nd:YAG laser (the fundamental band and its harmonics), ablation characteristics have been investigated in vitro for porcine myocardium tissue. At a constant laser intensity of ∼ 2.0 GW/cm2, the laser pulses irradiated the tissue and the depth of the ablation hole formed was measured. After the laser irradiation, the tissue was histologically analyzed with an optical microscope and a polarization optical microscope to evaluate the laser-induced damage in the tissue. It was found that the ablation rate for a 1064-nm laser irradiation was comparably high to that for a 355-nm laser irradiation, and the ablation efficiency was lower for a 266-nm laser irradiation than for a 355-nm laser irradiation. During the ablation, strong plasma formation was observed for 266 nm and 1064 nm, while the laser-induced optical emission was dominated by fluorescence for 355 nm. The histology showed that the thermal damage thickness decreased with decreasing the wavelength for 266, 355, and 532 nm, but for 1064 nm thermal damage was very limited although a certain extent of mechanical damage was observed. Based on these experimental results, the ablation mechanism for each laser wavelength and the optimum laser wavelength for the TMLR (transmyocardial laser revascularization) are discussed.",
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