Plasma nitric oxide metabolite levels are decreased in pre-eclamptic women complicated with fetal distress

H. Nanno, N. Sagawa, H. Itoh, T. Matsumoto, K. Terakawa, H. Mise, K. K. Okumura, T. Mori, Hiroshi Itoh, K. Nakao

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

To investigate the possible role of impairment of the maternal vascular nitric oxide (NO)-soluble guanylate cyclase system in the maintenance of placental oxygen supply to the fetus in pre-eclampsia, maternal plasma levels of nitric oxide metabolites (nitrate and nitrite, i.e. NOx), atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), and guanosine 3′,5′-cyclic phosphate (cGMP) were measured using Griess reagent, specific immunoradiometric assays (IRMA) and specific radioimmunoassay (RIA), respectively. The subjects were ten normal non-pregnant women, and 91 normal pregnant women, nine pre-eclamptic women without fetal distress and six pre-eclamptic women with fetal distress. In the pre-eclamptic women with fetal distress, plasma NOx levels were significantly (p < 0.05) lower than those in gestational age-matched normotensive pregnant women, but not in those without fetal distress. Plasma ANP and BNP levels in the pre-eclamptic pregnant women with fetal distress were significantly higher than those in gestational age-matched normotensive pregnant women. No significant differences were observed among plasma levels of cGMP, the common second messenger of both soluble and particulate guanylate cyclases. The present findings suggest that endothelial NO synthase (eNOS) is impaired in women whose pregnancies are complicated with pre-eclampsia and fetal distress.

Original languageEnglish
Pages (from-to)222-226
Number of pages5
JournalPrenatal and Neonatal Medicine
Volume3
Issue number2
Publication statusPublished - 1998 Apr
Externally publishedYes

Fingerprint

Fetal Distress
Nitric Oxide
Pregnant Women
Brain Natriuretic Peptide
Atrial Natriuretic Factor
Pre-Eclampsia
Gestational Age
Mothers
Immunoradiometric Assay
Guanosine
Nitric Oxide Synthase Type III
Second Messenger Systems
Nitrites
Nitrates
Radioimmunoassay
Blood Vessels
Fetus
Phosphates
Maintenance
Oxygen

Keywords

  • Atrial natriuretic peptide
  • Brain natriuretic peptide
  • Fetal distress
  • Guanosine 3′,5′-cyclic phosphate
  • Guanylate cyclase
  • Nitric oxide
  • Nitric oxide metabolites
  • Pre-eclampsia

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Nanno, H., Sagawa, N., Itoh, H., Matsumoto, T., Terakawa, K., Mise, H., ... Nakao, K. (1998). Plasma nitric oxide metabolite levels are decreased in pre-eclamptic women complicated with fetal distress. Prenatal and Neonatal Medicine, 3(2), 222-226.

Plasma nitric oxide metabolite levels are decreased in pre-eclamptic women complicated with fetal distress. / Nanno, H.; Sagawa, N.; Itoh, H.; Matsumoto, T.; Terakawa, K.; Mise, H.; Okumura, K. K.; Mori, T.; Itoh, Hiroshi; Nakao, K.

In: Prenatal and Neonatal Medicine, Vol. 3, No. 2, 04.1998, p. 222-226.

Research output: Contribution to journalArticle

Nanno, H, Sagawa, N, Itoh, H, Matsumoto, T, Terakawa, K, Mise, H, Okumura, KK, Mori, T, Itoh, H & Nakao, K 1998, 'Plasma nitric oxide metabolite levels are decreased in pre-eclamptic women complicated with fetal distress', Prenatal and Neonatal Medicine, vol. 3, no. 2, pp. 222-226.
Nanno H, Sagawa N, Itoh H, Matsumoto T, Terakawa K, Mise H et al. Plasma nitric oxide metabolite levels are decreased in pre-eclamptic women complicated with fetal distress. Prenatal and Neonatal Medicine. 1998 Apr;3(2):222-226.
Nanno, H. ; Sagawa, N. ; Itoh, H. ; Matsumoto, T. ; Terakawa, K. ; Mise, H. ; Okumura, K. K. ; Mori, T. ; Itoh, Hiroshi ; Nakao, K. / Plasma nitric oxide metabolite levels are decreased in pre-eclamptic women complicated with fetal distress. In: Prenatal and Neonatal Medicine. 1998 ; Vol. 3, No. 2. pp. 222-226.
@article{eb8a41f4cca4429893fbd35126821e9d,
title = "Plasma nitric oxide metabolite levels are decreased in pre-eclamptic women complicated with fetal distress",
abstract = "To investigate the possible role of impairment of the maternal vascular nitric oxide (NO)-soluble guanylate cyclase system in the maintenance of placental oxygen supply to the fetus in pre-eclampsia, maternal plasma levels of nitric oxide metabolites (nitrate and nitrite, i.e. NOx), atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), and guanosine 3′,5′-cyclic phosphate (cGMP) were measured using Griess reagent, specific immunoradiometric assays (IRMA) and specific radioimmunoassay (RIA), respectively. The subjects were ten normal non-pregnant women, and 91 normal pregnant women, nine pre-eclamptic women without fetal distress and six pre-eclamptic women with fetal distress. In the pre-eclamptic women with fetal distress, plasma NOx levels were significantly (p < 0.05) lower than those in gestational age-matched normotensive pregnant women, but not in those without fetal distress. Plasma ANP and BNP levels in the pre-eclamptic pregnant women with fetal distress were significantly higher than those in gestational age-matched normotensive pregnant women. No significant differences were observed among plasma levels of cGMP, the common second messenger of both soluble and particulate guanylate cyclases. The present findings suggest that endothelial NO synthase (eNOS) is impaired in women whose pregnancies are complicated with pre-eclampsia and fetal distress.",
keywords = "Atrial natriuretic peptide, Brain natriuretic peptide, Fetal distress, Guanosine 3′,5′-cyclic phosphate, Guanylate cyclase, Nitric oxide, Nitric oxide metabolites, Pre-eclampsia",
author = "H. Nanno and N. Sagawa and H. Itoh and T. Matsumoto and K. Terakawa and H. Mise and Okumura, {K. K.} and T. Mori and Hiroshi Itoh and K. Nakao",
year = "1998",
month = "4",
language = "English",
volume = "3",
pages = "222--226",
journal = "Journal of Maternal-Fetal and Neonatal Medicine",
issn = "1476-7058",
publisher = "Informa Healthcare",
number = "2",

}

TY - JOUR

T1 - Plasma nitric oxide metabolite levels are decreased in pre-eclamptic women complicated with fetal distress

AU - Nanno, H.

AU - Sagawa, N.

AU - Itoh, H.

AU - Matsumoto, T.

AU - Terakawa, K.

AU - Mise, H.

AU - Okumura, K. K.

AU - Mori, T.

AU - Itoh, Hiroshi

AU - Nakao, K.

PY - 1998/4

Y1 - 1998/4

N2 - To investigate the possible role of impairment of the maternal vascular nitric oxide (NO)-soluble guanylate cyclase system in the maintenance of placental oxygen supply to the fetus in pre-eclampsia, maternal plasma levels of nitric oxide metabolites (nitrate and nitrite, i.e. NOx), atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), and guanosine 3′,5′-cyclic phosphate (cGMP) were measured using Griess reagent, specific immunoradiometric assays (IRMA) and specific radioimmunoassay (RIA), respectively. The subjects were ten normal non-pregnant women, and 91 normal pregnant women, nine pre-eclamptic women without fetal distress and six pre-eclamptic women with fetal distress. In the pre-eclamptic women with fetal distress, plasma NOx levels were significantly (p < 0.05) lower than those in gestational age-matched normotensive pregnant women, but not in those without fetal distress. Plasma ANP and BNP levels in the pre-eclamptic pregnant women with fetal distress were significantly higher than those in gestational age-matched normotensive pregnant women. No significant differences were observed among plasma levels of cGMP, the common second messenger of both soluble and particulate guanylate cyclases. The present findings suggest that endothelial NO synthase (eNOS) is impaired in women whose pregnancies are complicated with pre-eclampsia and fetal distress.

AB - To investigate the possible role of impairment of the maternal vascular nitric oxide (NO)-soluble guanylate cyclase system in the maintenance of placental oxygen supply to the fetus in pre-eclampsia, maternal plasma levels of nitric oxide metabolites (nitrate and nitrite, i.e. NOx), atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), and guanosine 3′,5′-cyclic phosphate (cGMP) were measured using Griess reagent, specific immunoradiometric assays (IRMA) and specific radioimmunoassay (RIA), respectively. The subjects were ten normal non-pregnant women, and 91 normal pregnant women, nine pre-eclamptic women without fetal distress and six pre-eclamptic women with fetal distress. In the pre-eclamptic women with fetal distress, plasma NOx levels were significantly (p < 0.05) lower than those in gestational age-matched normotensive pregnant women, but not in those without fetal distress. Plasma ANP and BNP levels in the pre-eclamptic pregnant women with fetal distress were significantly higher than those in gestational age-matched normotensive pregnant women. No significant differences were observed among plasma levels of cGMP, the common second messenger of both soluble and particulate guanylate cyclases. The present findings suggest that endothelial NO synthase (eNOS) is impaired in women whose pregnancies are complicated with pre-eclampsia and fetal distress.

KW - Atrial natriuretic peptide

KW - Brain natriuretic peptide

KW - Fetal distress

KW - Guanosine 3′,5′-cyclic phosphate

KW - Guanylate cyclase

KW - Nitric oxide

KW - Nitric oxide metabolites

KW - Pre-eclampsia

UR - http://www.scopus.com/inward/record.url?scp=0347248941&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0347248941&partnerID=8YFLogxK

M3 - Article

VL - 3

SP - 222

EP - 226

JO - Journal of Maternal-Fetal and Neonatal Medicine

JF - Journal of Maternal-Fetal and Neonatal Medicine

SN - 1476-7058

IS - 2

ER -