TY - JOUR
T1 - Plasma phospholipid n-3 polyunsaturated fatty acids and major depressive disorder in Japanese elderly
T2 - the Japan Public Health Center-based Prospective Study
AU - Hamazaki, Kei
AU - Matsuoka, Yutaka J.
AU - Yamaji, Taiki
AU - Sawada, Norie
AU - Mimura, Masaru
AU - Nozaki, Shoko
AU - Shikimoto, Ryo
AU - Tsugane, Shoichiro
N1 - Funding Information:
Dr. Matsuoka has received speaker fees from Suntory, Pfizer, Mochida, Eli Lilly, Morinaga Milk, and NTT Data, is conducting collaborative research with Morinaga Milk and SUSMED, and has received a grant from SENSHIN Medical Research Foundation. Dr. Hamazaki has received a research grant from the First Bank of Toyama Scholarship Foundation, speaking honoraria from the DHA&EPA Association, Niigata Medical Association, Toyama Medical Association, and Toyama Occupational Health Promotion Center, and a supervision fee from Otsuka Pharmaceutical Factory. The remaining authors report no conflicts of interest.
Funding Information:
The authors thank the Japan Public Health Center-based Prospective Study Group and all staff members in the Saku area for their extensive efforts to conduct the survey. The cohort study was originally supported by the National Cancer Center Research and Development Fund (since 2011) and a Grant-in-Aid for Cancer Research from the Ministry of Health, Labour, and Welfare of Japan (1989-2010). This study was supported by a Grant-in-Aid for Scientific Research (B) from the Japan Society for the Promotion of Science (No. 17H04253) and the SENSHIN Medical Research Foundation. The funding agencies had no role in the design and conduct of the study; data collection, management, analysis, and interpretation of the data; review or approval of the manuscript; and decision to submit the manuscript for publication. The views expressed in this article are those of the authors and do not necessarily represent the views of the National Cancer Center Japan.
Publisher Copyright:
© 2021, The Author(s).
PY - 2021/12
Y1 - 2021/12
N2 - The beneficial effects of n-3 polyunsaturated fatty acids (PUFAs) such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on depression are not definitively known. In a previous population-based prospective cohort study, we found a reverse J-shaped association of intake of fish and docosapentaenoic acid (DPA), the intermediate metabolite of EPA and DHA, with major depressive disorder (MDD). To examine the association further in a cross-sectional manner, in the present study we analyzed the level of plasma phospholipid n-3 PUFAs and the risk of MDD in 1,213 participants aged 64–86 years (mean 72.9 years) who completed questionnaires and underwent medical check-ups, a mental health examination, and blood collection. In multivariate logistic regression analysis, odds ratios and 95% confidence intervals were calculated for MDD according to plasma phospholipid n-3 PUFA quartiles. MDD was diagnosed in 103 individuals. There were no significant differences in any n-3 PUFAs (i.e., EPA, DHA, or DPA) between individuals with and without MDD. Multivariate logistic regression analysis showed no significant association between any individual n-3 PUFAs and MDD risk. Overall, based on the results of this cross-sectional study, there appears to be no association of plasma phospholipid n-3 PUFAs with MDD risk in the elderly Japanese population.
AB - The beneficial effects of n-3 polyunsaturated fatty acids (PUFAs) such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on depression are not definitively known. In a previous population-based prospective cohort study, we found a reverse J-shaped association of intake of fish and docosapentaenoic acid (DPA), the intermediate metabolite of EPA and DHA, with major depressive disorder (MDD). To examine the association further in a cross-sectional manner, in the present study we analyzed the level of plasma phospholipid n-3 PUFAs and the risk of MDD in 1,213 participants aged 64–86 years (mean 72.9 years) who completed questionnaires and underwent medical check-ups, a mental health examination, and blood collection. In multivariate logistic regression analysis, odds ratios and 95% confidence intervals were calculated for MDD according to plasma phospholipid n-3 PUFA quartiles. MDD was diagnosed in 103 individuals. There were no significant differences in any n-3 PUFAs (i.e., EPA, DHA, or DPA) between individuals with and without MDD. Multivariate logistic regression analysis showed no significant association between any individual n-3 PUFAs and MDD risk. Overall, based on the results of this cross-sectional study, there appears to be no association of plasma phospholipid n-3 PUFAs with MDD risk in the elderly Japanese population.
UR - http://www.scopus.com/inward/record.url?scp=85101038378&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85101038378&partnerID=8YFLogxK
U2 - 10.1038/s41598-021-83478-5
DO - 10.1038/s41598-021-83478-5
M3 - Article
C2 - 33597590
AN - SCOPUS:85101038378
SN - 2045-2322
VL - 11
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 4003
ER -
