TY - JOUR
T1 - Plasma platelet-derived microparticles in patients with connective tissue diseases
AU - Oyabu, Chinami
AU - Morinobu, Akio
AU - Sugiyama, Daisuke
AU - Saegusa, Jun
AU - Tanaka, Shino
AU - Morinobu, Sahoko
AU - Tsuji, Goh
AU - Kasagi, Shimpei
AU - Kawano, Seiji
AU - Kumagai, Shunichi
N1 - Copyright:
Copyright 2011 Elsevier B.V., All rights reserved.
PY - 2011/4
Y1 - 2011/4
N2 - Objective. To clarify the role of platelet-derived microparticles (PDMP), which are small vesicles with thrombotic and immunological properties, in systemic lupus erythematosus (SLE), systemic sclerosis (SSc), dermatomyositis/polymyositis (PM/DM), and mixed connective tissue disease (MCTD). Methods. Plasma levels of PDMP were measured by ELISA, and compared among patients with one of the 4 diseases. Association of PDMP levels with clinical characteristics and medication of the patients was also examined. Results. PDMP levels were higher in patients with MCTD and SSc than in controls. Multiple linear regression analysis revealed that patients with Raynaud's phenomenon (RP) showed higher PDMP levels than those without. PDMP levels in individual patients did not fluctuate significantly over several months. Conclusion. PDMP level is associated with MCTD, SSc, and RP, and could be a novel marker for RP. The Journal of Rheumatology
AB - Objective. To clarify the role of platelet-derived microparticles (PDMP), which are small vesicles with thrombotic and immunological properties, in systemic lupus erythematosus (SLE), systemic sclerosis (SSc), dermatomyositis/polymyositis (PM/DM), and mixed connective tissue disease (MCTD). Methods. Plasma levels of PDMP were measured by ELISA, and compared among patients with one of the 4 diseases. Association of PDMP levels with clinical characteristics and medication of the patients was also examined. Results. PDMP levels were higher in patients with MCTD and SSc than in controls. Multiple linear regression analysis revealed that patients with Raynaud's phenomenon (RP) showed higher PDMP levels than those without. PDMP levels in individual patients did not fluctuate significantly over several months. Conclusion. PDMP level is associated with MCTD, SSc, and RP, and could be a novel marker for RP. The Journal of Rheumatology
KW - Connective tissue diseases
KW - Microparticle
KW - Platelet
KW - Raynaud's phenomenon
UR - http://www.scopus.com/inward/record.url?scp=79953332135&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79953332135&partnerID=8YFLogxK
U2 - 10.3899/jrheum.100780
DO - 10.3899/jrheum.100780
M3 - Article
C2 - 21239749
AN - SCOPUS:79953332135
SN - 0315-162X
VL - 38
SP - 680
EP - 684
JO - Journal of Rheumatology
JF - Journal of Rheumatology
IS - 4
ER -