Plasma platelet-derived microparticles in patients with connective tissue diseases

Chinami Oyabu, Akio Morinobu, Daisuke Sugiyama, Jun Saegusa, Shino Tanaka, Sahoko Morinobu, Goh Tsuji, Shimpei Kasagi, Seiji Kawano, Shunichi Kumagai

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


Objective. To clarify the role of platelet-derived microparticles (PDMP), which are small vesicles with thrombotic and immunological properties, in systemic lupus erythematosus (SLE), systemic sclerosis (SSc), dermatomyositis/polymyositis (PM/DM), and mixed connective tissue disease (MCTD). Methods. Plasma levels of PDMP were measured by ELISA, and compared among patients with one of the 4 diseases. Association of PDMP levels with clinical characteristics and medication of the patients was also examined. Results. PDMP levels were higher in patients with MCTD and SSc than in controls. Multiple linear regression analysis revealed that patients with Raynaud's phenomenon (RP) showed higher PDMP levels than those without. PDMP levels in individual patients did not fluctuate significantly over several months. Conclusion. PDMP level is associated with MCTD, SSc, and RP, and could be a novel marker for RP. The Journal of Rheumatology

Original languageEnglish
Pages (from-to)680-684
Number of pages5
JournalJournal of Rheumatology
Issue number4
Publication statusPublished - 2011 Apr
Externally publishedYes


  • Connective tissue diseases
  • Microparticle
  • Platelet
  • Raynaud's phenomenon

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology


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