Plasma sE-cadherin and the plasma sE-cadherin/sVE-cadherin ratio are potential biomarkers for chronic obstructive pulmonary disease

Toru Shirahata, Hidetoshi Nakamura, Takahiro Nakajima, Miho Nakamura, Shotaro Chubachi, Shuichi Yoshida, Keishi Tsuduki, Shuko Mashimo, Saeko Takahashi, Naoto Minematsu, Hiroki Tateno, Koichiro Asano, Seitaro Fujishima, Tomoko Betsuyaku

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Chronic obstructive pulmonary disease (COPD) is characterized by airway inflammation with endothelial dysfunction. Cadherins are adhesion molecules on epithelial (E-) and vascular endothelial (VE-) cells. Soluble (s) cadherin is released from the cell surface by the effects of proteases including matrix metalloproteinases (MMPs). Objective: The aim of this study was to examine the associations of sE-/sVE-cadherin levels in plasma with the development of COPD. Methods: Plasma sE-/VE-cadherin levels were measured by an enzyme-linked immunosorbent assay in 115 patients with COPD, 36 symptomatic smokers (SS), 63 healthy smokers (HS) and 78 healthy non-smokers (HN). sE-cadherin and MMP-7 levels in epithelial lining fluid (ELF) were measured in 24 patients (12 COPD and 12 control). Results: Plasma sE-cadherin levels and sE-cadherin/sVE-cadherin ratios were significantly higher in COPD and SS than in HS and HN groups, while plasma sVE-cadherin levels were lower in COPD than in HS and HN groups (p < 0.0001). sE-cadherin levels paralleled the severity of airflow limitation in both plasma (p < 0.01) and ELF (p < 0.05), while plasma sVE-cadherin levels were inversely correlated with the extent of emphysema (p < 0.05). MMP-7 levels were correlated with sE-cadherin levels in ELF. Conclusions: Plasma sE-cadherin levels and sE-cadherin/sVE-cadherin ratios are potential biomarkers for COPD.

Original languageEnglish
Pages (from-to)1-8
Number of pages8
JournalBiomarkers
DOIs
Publication statusAccepted/In press - 2018 Feb 12

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Keywords

  • biomarker
  • COPD
  • E-cadherin
  • MMP-7
  • VE-cadherin

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Health, Toxicology and Mutagenesis

Cite this

Shirahata, T., Nakamura, H., Nakajima, T., Nakamura, M., Chubachi, S., Yoshida, S., Tsuduki, K., Mashimo, S., Takahashi, S., Minematsu, N., Tateno, H., Asano, K., Fujishima, S., & Betsuyaku, T. (Accepted/In press). Plasma sE-cadherin and the plasma sE-cadherin/sVE-cadherin ratio are potential biomarkers for chronic obstructive pulmonary disease. Biomarkers, 1-8. https://doi.org/10.1080/1354750X.2018.1434682