Plasma sE-cadherin and the plasma sE-cadherin/sVE-cadherin ratio are potential biomarkers for chronic obstructive pulmonary disease

Toru Shirahata; Hidetoshi Nakamura; Takahiro Nakajima; Miho Nakamura; Shotaro Chubachi; Shuichi Yoshida; Keishi Tsuduki; Shuko Mashimo; Saeko Takahashi; Naoto Minematsu; Hiroki Tateno; Koichiro Asano; Seitaro Fujishima; Tomoko Betsuyaku

doi:10.1080/1354750X.2018.1434682

Plasma sE-cadherin and the plasma sE-cadherin/sVE-cadherin ratio are potential biomarkers for chronic obstructive pulmonary disease

Toru Shirahata, Hidetoshi Nakamura, Takahiro Nakajima, Miho Nakamura, Shotaro Chubachi, Shuichi Yoshida, Keishi Tsuduki, Shuko Mashimo, Saeko Takahashi, Naoto Minematsu, Hiroki Tateno, Koichiro Asano, Seitaro Fujishima, Tomoko Betsuyaku

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

Background: Chronic obstructive pulmonary disease (COPD) is characterized by airway inflammation with endothelial dysfunction. Cadherins are adhesion molecules on epithelial (E-) and vascular endothelial (VE-) cells. Soluble (s) cadherin is released from the cell surface by the effects of proteases including matrix metalloproteinases (MMPs). Objective: The aim of this study was to examine the associations of sE-/sVE-cadherin levels in plasma with the development of COPD. Methods: Plasma sE-/VE-cadherin levels were measured by an enzyme-linked immunosorbent assay in 115 patients with COPD, 36 symptomatic smokers (SS), 63 healthy smokers (HS) and 78 healthy non-smokers (HN). sE-cadherin and MMP-7 levels in epithelial lining fluid (ELF) were measured in 24 patients (12 COPD and 12 control). Results: Plasma sE-cadherin levels and sE-cadherin/sVE-cadherin ratios were significantly higher in COPD and SS than in HS and HN groups, while plasma sVE-cadherin levels were lower in COPD than in HS and HN groups (p < 0.0001). sE-cadherin levels paralleled the severity of airflow limitation in both plasma (p < 0.01) and ELF (p < 0.05), while plasma sVE-cadherin levels were inversely correlated with the extent of emphysema (p < 0.05). MMP-7 levels were correlated with sE-cadherin levels in ELF. Conclusions: Plasma sE-cadherin levels and sE-cadherin/sVE-cadherin ratios are potential biomarkers for COPD.

Original language	English
Pages (from-to)	414-421
Number of pages	8
Journal	Biomarkers
Volume	23
Issue number	5
DOIs	https://doi.org/10.1080/1354750X.2018.1434682
Publication status	Published - 2018 Jul 4

Keywords

COPD
E-cadherin
MMP-7
VE-cadherin
biomarker

ASJC Scopus subject areas

Biochemistry
Clinical Biochemistry
Health, Toxicology and Mutagenesis

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10.1080/1354750X.2018.1434682

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Shirahata, T., Nakamura, H., Nakajima, T., Nakamura, M., Chubachi, S., Yoshida, S., Tsuduki, K., Mashimo, S., Takahashi, S., Minematsu, N., Tateno, H., Asano, K., Fujishima, S., & Betsuyaku, T. (2018). Plasma sE-cadherin and the plasma sE-cadherin/sVE-cadherin ratio are potential biomarkers for chronic obstructive pulmonary disease. Biomarkers, 23(5), 414-421. https://doi.org/10.1080/1354750X.2018.1434682

Shirahata, T, Nakamura, H, Nakajima, T, Nakamura, M, Chubachi, S, Yoshida, S, Tsuduki, K, Mashimo, S, Takahashi, S, Minematsu, N, Tateno, H, Asano, K, Fujishima, S & Betsuyaku, T 2018, 'Plasma sE-cadherin and the plasma sE-cadherin/sVE-cadherin ratio are potential biomarkers for chronic obstructive pulmonary disease', Biomarkers, vol. 23, no. 5, pp. 414-421. https://doi.org/10.1080/1354750X.2018.1434682

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title = "Plasma sE-cadherin and the plasma sE-cadherin/sVE-cadherin ratio are potential biomarkers for chronic obstructive pulmonary disease",

abstract = "Background: Chronic obstructive pulmonary disease (COPD) is characterized by airway inflammation with endothelial dysfunction. Cadherins are adhesion molecules on epithelial (E-) and vascular endothelial (VE-) cells. Soluble (s) cadherin is released from the cell surface by the effects of proteases including matrix metalloproteinases (MMPs). Objective: The aim of this study was to examine the associations of sE-/sVE-cadherin levels in plasma with the development of COPD. Methods: Plasma sE-/VE-cadherin levels were measured by an enzyme-linked immunosorbent assay in 115 patients with COPD, 36 symptomatic smokers (SS), 63 healthy smokers (HS) and 78 healthy non-smokers (HN). sE-cadherin and MMP-7 levels in epithelial lining fluid (ELF) were measured in 24 patients (12 COPD and 12 control). Results: Plasma sE-cadherin levels and sE-cadherin/sVE-cadherin ratios were significantly higher in COPD and SS than in HS and HN groups, while plasma sVE-cadherin levels were lower in COPD than in HS and HN groups (p < 0.0001). sE-cadherin levels paralleled the severity of airflow limitation in both plasma (p < 0.01) and ELF (p < 0.05), while plasma sVE-cadherin levels were inversely correlated with the extent of emphysema (p < 0.05). MMP-7 levels were correlated with sE-cadherin levels in ELF. Conclusions: Plasma sE-cadherin levels and sE-cadherin/sVE-cadherin ratios are potential biomarkers for COPD.",

keywords = "COPD, E-cadherin, MMP-7, VE-cadherin, biomarker",

author = "Toru Shirahata and Hidetoshi Nakamura and Takahiro Nakajima and Miho Nakamura and Shotaro Chubachi and Shuichi Yoshida and Keishi Tsuduki and Shuko Mashimo and Saeko Takahashi and Naoto Minematsu and Hiroki Tateno and Koichiro Asano and Seitaro Fujishima and Tomoko Betsuyaku",

note = "Funding Information: This study was supported in part by a grant to the Respiratory Failure Research Group from the Ministry of Health, Labour and Welfare of Japan. The authors would like to thank Professor Kazuhiro Yamaguchi (Tokyo Women{\textquoteright}s Medical University) and the late Professor Akitoshi Ishizaka (Keio University) for their insightful comments for this study. They also appreciate the technical assistance of Ms. Miyuki Yamamoto (Keio University). Funding Information: This study was supported in part by a grant to the Respiratory Failure Research Group from the Ministry of Health, Labour and Welfare of Japan. Publisher Copyright: {\textcopyright} 2018 Informa UK Limited, trading as Taylor & Francis Group.",

year = "2018",

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doi = "10.1080/1354750X.2018.1434682",

language = "English",

volume = "23",

pages = "414--421",

journal = "Biomarkers",

issn = "1354-750X",

publisher = "Informa Healthcare",

number = "5",

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TY - JOUR

T1 - Plasma sE-cadherin and the plasma sE-cadherin/sVE-cadherin ratio are potential biomarkers for chronic obstructive pulmonary disease

AU - Shirahata, Toru

AU - Nakamura, Hidetoshi

AU - Nakajima, Takahiro

AU - Nakamura, Miho

AU - Chubachi, Shotaro

AU - Yoshida, Shuichi

AU - Tsuduki, Keishi

AU - Mashimo, Shuko

AU - Takahashi, Saeko

AU - Minematsu, Naoto

AU - Tateno, Hiroki

AU - Asano, Koichiro

AU - Fujishima, Seitaro

AU - Betsuyaku, Tomoko

N1 - Funding Information: This study was supported in part by a grant to the Respiratory Failure Research Group from the Ministry of Health, Labour and Welfare of Japan. The authors would like to thank Professor Kazuhiro Yamaguchi (Tokyo Women’s Medical University) and the late Professor Akitoshi Ishizaka (Keio University) for their insightful comments for this study. They also appreciate the technical assistance of Ms. Miyuki Yamamoto (Keio University). Funding Information: This study was supported in part by a grant to the Respiratory Failure Research Group from the Ministry of Health, Labour and Welfare of Japan. Publisher Copyright: © 2018 Informa UK Limited, trading as Taylor & Francis Group.

PY - 2018/7/4

Y1 - 2018/7/4

N2 - Background: Chronic obstructive pulmonary disease (COPD) is characterized by airway inflammation with endothelial dysfunction. Cadherins are adhesion molecules on epithelial (E-) and vascular endothelial (VE-) cells. Soluble (s) cadherin is released from the cell surface by the effects of proteases including matrix metalloproteinases (MMPs). Objective: The aim of this study was to examine the associations of sE-/sVE-cadherin levels in plasma with the development of COPD. Methods: Plasma sE-/VE-cadherin levels were measured by an enzyme-linked immunosorbent assay in 115 patients with COPD, 36 symptomatic smokers (SS), 63 healthy smokers (HS) and 78 healthy non-smokers (HN). sE-cadherin and MMP-7 levels in epithelial lining fluid (ELF) were measured in 24 patients (12 COPD and 12 control). Results: Plasma sE-cadherin levels and sE-cadherin/sVE-cadherin ratios were significantly higher in COPD and SS than in HS and HN groups, while plasma sVE-cadherin levels were lower in COPD than in HS and HN groups (p < 0.0001). sE-cadherin levels paralleled the severity of airflow limitation in both plasma (p < 0.01) and ELF (p < 0.05), while plasma sVE-cadherin levels were inversely correlated with the extent of emphysema (p < 0.05). MMP-7 levels were correlated with sE-cadherin levels in ELF. Conclusions: Plasma sE-cadherin levels and sE-cadherin/sVE-cadherin ratios are potential biomarkers for COPD.

AB - Background: Chronic obstructive pulmonary disease (COPD) is characterized by airway inflammation with endothelial dysfunction. Cadherins are adhesion molecules on epithelial (E-) and vascular endothelial (VE-) cells. Soluble (s) cadherin is released from the cell surface by the effects of proteases including matrix metalloproteinases (MMPs). Objective: The aim of this study was to examine the associations of sE-/sVE-cadherin levels in plasma with the development of COPD. Methods: Plasma sE-/VE-cadherin levels were measured by an enzyme-linked immunosorbent assay in 115 patients with COPD, 36 symptomatic smokers (SS), 63 healthy smokers (HS) and 78 healthy non-smokers (HN). sE-cadherin and MMP-7 levels in epithelial lining fluid (ELF) were measured in 24 patients (12 COPD and 12 control). Results: Plasma sE-cadherin levels and sE-cadherin/sVE-cadherin ratios were significantly higher in COPD and SS than in HS and HN groups, while plasma sVE-cadherin levels were lower in COPD than in HS and HN groups (p < 0.0001). sE-cadherin levels paralleled the severity of airflow limitation in both plasma (p < 0.01) and ELF (p < 0.05), while plasma sVE-cadherin levels were inversely correlated with the extent of emphysema (p < 0.05). MMP-7 levels were correlated with sE-cadherin levels in ELF. Conclusions: Plasma sE-cadherin levels and sE-cadherin/sVE-cadherin ratios are potential biomarkers for COPD.

KW - COPD

KW - E-cadherin

KW - MMP-7

KW - VE-cadherin

KW - biomarker

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Plasma sE-cadherin and the plasma sE-cadherin/sVE-cadherin ratio are potential biomarkers for chronic obstructive pulmonary disease

Abstract

Keywords

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