Abstract
Background: Chronic obstructive pulmonary disease (COPD) is characterized by airway inflammation with endothelial dysfunction. Cadherins are adhesion molecules on epithelial (E-) and vascular endothelial (VE-) cells. Soluble (s) cadherin is released from the cell surface by the effects of proteases including matrix metalloproteinases (MMPs). Objective: The aim of this study was to examine the associations of sE-/sVE-cadherin levels in plasma with the development of COPD. Methods: Plasma sE-/VE-cadherin levels were measured by an enzyme-linked immunosorbent assay in 115 patients with COPD, 36 symptomatic smokers (SS), 63 healthy smokers (HS) and 78 healthy non-smokers (HN). sE-cadherin and MMP-7 levels in epithelial lining fluid (ELF) were measured in 24 patients (12 COPD and 12 control). Results: Plasma sE-cadherin levels and sE-cadherin/sVE-cadherin ratios were significantly higher in COPD and SS than in HS and HN groups, while plasma sVE-cadherin levels were lower in COPD than in HS and HN groups (p < 0.0001). sE-cadherin levels paralleled the severity of airflow limitation in both plasma (p < 0.01) and ELF (p < 0.05), while plasma sVE-cadherin levels were inversely correlated with the extent of emphysema (p < 0.05). MMP-7 levels were correlated with sE-cadherin levels in ELF. Conclusions: Plasma sE-cadherin levels and sE-cadherin/sVE-cadherin ratios are potential biomarkers for COPD.
| Original language | English |
|---|---|
| Pages (from-to) | 1-8 |
| Number of pages | 8 |
| Journal | Biomarkers |
| DOIs | |
| Publication status | Accepted/In press - 2018 Feb 12 |
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Keywords
- biomarker
- COPD
- E-cadherin
- MMP-7
- VE-cadherin
ASJC Scopus subject areas
- Biochemistry
- Clinical Biochemistry
- Health, Toxicology and Mutagenesis
Cite this
Plasma sE-cadherin and the plasma sE-cadherin/sVE-cadherin ratio are potential biomarkers for chronic obstructive pulmonary disease. / Shirahata, Toru; Nakamura, Hidetoshi; Nakajima, Takahiro; Nakamura, Miho; Chubachi, Shotaro; Yoshida, Shuichi; Tsuduki, Keishi; Mashimo, Shuko; Takahashi, Saeko; Minematsu, Naoto; Tateno, Hiroki; Asano, Koichiro; Fujishima, Seitaro; Betsuyaku, Tomoko.
In: Biomarkers, 12.02.2018, p. 1-8.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Plasma sE-cadherin and the plasma sE-cadherin/sVE-cadherin ratio are potential biomarkers for chronic obstructive pulmonary disease
AU - Shirahata, Toru
AU - Nakamura, Hidetoshi
AU - Nakajima, Takahiro
AU - Nakamura, Miho
AU - Chubachi, Shotaro
AU - Yoshida, Shuichi
AU - Tsuduki, Keishi
AU - Mashimo, Shuko
AU - Takahashi, Saeko
AU - Minematsu, Naoto
AU - Tateno, Hiroki
AU - Asano, Koichiro
AU - Fujishima, Seitaro
AU - Betsuyaku, Tomoko
PY - 2018/2/12
Y1 - 2018/2/12
N2 - Background: Chronic obstructive pulmonary disease (COPD) is characterized by airway inflammation with endothelial dysfunction. Cadherins are adhesion molecules on epithelial (E-) and vascular endothelial (VE-) cells. Soluble (s) cadherin is released from the cell surface by the effects of proteases including matrix metalloproteinases (MMPs). Objective: The aim of this study was to examine the associations of sE-/sVE-cadherin levels in plasma with the development of COPD. Methods: Plasma sE-/VE-cadherin levels were measured by an enzyme-linked immunosorbent assay in 115 patients with COPD, 36 symptomatic smokers (SS), 63 healthy smokers (HS) and 78 healthy non-smokers (HN). sE-cadherin and MMP-7 levels in epithelial lining fluid (ELF) were measured in 24 patients (12 COPD and 12 control). Results: Plasma sE-cadherin levels and sE-cadherin/sVE-cadherin ratios were significantly higher in COPD and SS than in HS and HN groups, while plasma sVE-cadherin levels were lower in COPD than in HS and HN groups (p < 0.0001). sE-cadherin levels paralleled the severity of airflow limitation in both plasma (p < 0.01) and ELF (p < 0.05), while plasma sVE-cadherin levels were inversely correlated with the extent of emphysema (p < 0.05). MMP-7 levels were correlated with sE-cadherin levels in ELF. Conclusions: Plasma sE-cadherin levels and sE-cadherin/sVE-cadherin ratios are potential biomarkers for COPD.
AB - Background: Chronic obstructive pulmonary disease (COPD) is characterized by airway inflammation with endothelial dysfunction. Cadherins are adhesion molecules on epithelial (E-) and vascular endothelial (VE-) cells. Soluble (s) cadherin is released from the cell surface by the effects of proteases including matrix metalloproteinases (MMPs). Objective: The aim of this study was to examine the associations of sE-/sVE-cadherin levels in plasma with the development of COPD. Methods: Plasma sE-/VE-cadherin levels were measured by an enzyme-linked immunosorbent assay in 115 patients with COPD, 36 symptomatic smokers (SS), 63 healthy smokers (HS) and 78 healthy non-smokers (HN). sE-cadherin and MMP-7 levels in epithelial lining fluid (ELF) were measured in 24 patients (12 COPD and 12 control). Results: Plasma sE-cadherin levels and sE-cadherin/sVE-cadherin ratios were significantly higher in COPD and SS than in HS and HN groups, while plasma sVE-cadherin levels were lower in COPD than in HS and HN groups (p < 0.0001). sE-cadherin levels paralleled the severity of airflow limitation in both plasma (p < 0.01) and ELF (p < 0.05), while plasma sVE-cadherin levels were inversely correlated with the extent of emphysema (p < 0.05). MMP-7 levels were correlated with sE-cadherin levels in ELF. Conclusions: Plasma sE-cadherin levels and sE-cadherin/sVE-cadherin ratios are potential biomarkers for COPD.
KW - biomarker
KW - COPD
KW - E-cadherin
KW - MMP-7
KW - VE-cadherin
UR - http://www.scopus.com/inward/record.url?scp=85041922763&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85041922763&partnerID=8YFLogxK
U2 - 10.1080/1354750X.2018.1434682
DO - 10.1080/1354750X.2018.1434682
M3 - Article
C2 - 29376431
AN - SCOPUS:85041922763
SP - 1
EP - 8
JO - Biomarkers
JF - Biomarkers
SN - 1354-750X
ER -